DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(1)G0289 and Plxdc1

DIOPT Version :9

Sequence 1:	NP_001303555.1	Gene:	l(1)G0289 / 31964	FlyBaseID:	FBgn0028331	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001100516.1	Gene:	Plxdc1 / 303505	RGDID:	1307496	Length:	500	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	165/487 - (33%)
Similarity:	240/487 - (49%)	Gaps:	53/487 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 VAPAVDSNTTSQMAPA-TKKPTLLGQSGNPKKVASSVVAATMTDPSPAVIDVDV---SKVVD-VP 196
            ::||..:....:...| |.|.|..|.:...::....|:     .|....:..|:   |..:| :|
  Rat    20 LSPATPAGHDERQGSAWTAKRTRQGWNRRVRESPGQVL-----KPGKTQLSQDLGGDSLAIDTLP 79

  Fly   197 EEEIEAAVKNASLKESVDFHEYYNSVLY-ENKDEVASLWTELKATPEN-----IMLSSSHRRAMT 255
            :........|         |.||.|.:| ..:.....||.:|.....|     .:||||||:|..
  Rat    80 DNRTRVVEDN---------HNYYVSRVYGPGEQRTRDLWVDLSVANRNHVKVHRILSSSHRQASR 135

  Fly   256 VELKFDFPFYGHFVRNITVATGGFLYTGEYVHSWLAATQYIAPLMANFDTSMSNDSFVRLHDNGT 320
            |.|.||||||||.:|.||:|||||::.|:.:|..|.||||:|||||||:...|::|.|...||||
  Rat   136 VVLSFDFPFYGHPLRQITIATGGFIFMGDVLHRMLTATQYVAPLMANFNPGYSDNSTVAYFDNGT 200

  Fly   321 AFTAVWENVTLQDKPDFGKFTFSVTLYQSGDIVFAYMLVPTNINSIQDKEHPVKVGLSDAYII-- 383
            .|...|::|.||.:.|.|.|||...|:|.|.|||.|..:|..:..|...:||||.|||||::|
  Rat   201 VFVVQWDHVYLQGREDRGSFTFQAALHQDGRIVFGYKEIPMAVLDISSAQHPVKAGLSDAFMILN 265

  Fly   384 -DKQLFFARRKTIYEYHRVTFQQHEITNNTIIKLAAQPTCLGYNDCNSCINHNTTFTCLWCSVLN 447
             ..::..:||:||:|||||.....:||..:.::....||||.:..|::|::.|.||.|.||.||.
  Rat   266 SSPEVPESRRRTIFEYHRVELDSSKITTTSAVEFTPLPTCLQHQSCDACMSSNLTFNCSWCYVLQ 330

  Fly   448 RCSTGTDRKKHEWLQMGCEATAIHTSSLCPALGDKGNNAAGQGKNGSANSGASANGATNTSTSSS 512
            |||:|.||.:.|||..||...|  ....|....|:|:.:|....:.|.:.|.|      |::||.
  Rat   331 RCSSGFDRYRQEWLTYGCAQEA--EGKTCEHFQDEGHYSASPDSSFSPSDGGS------TTSSSL 387

  Fly   513 GSSTPVTEPSVMSTRAPHATAYIKPGVDHSSDIHADGKVGNAELSKAEADNKNVGVAFGFMVPIC 577
            ...:..||......  |:|              ..||...|:. .|.:....::|...|.::.:.
  Rat   388 FIDSLTTEDDTKLN--PYA--------------EGDGLPDNSS-PKTKGPPVHLGTIVGIVLAVL 435

  Fly   578 LVFAVTLWLFYAYRNPHTKSGQLLIQFRPSQW 609
            ||.|:.|...|...:|::.:....|:.||..|
  Rat   436 LVAAIILAGIYISGHPNSNAALFFIERRPHHW 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0289	NP_001303555.1	PSI	421..477	CDD:279745	25/55 (45%)
Plxdc1	NP_001100516.1	NIDO	165..>259	CDD:295411	45/93 (48%)
Plxdc1	NP_001100516.1	PSI	304..348	CDD:279745	22/43 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335363
Domainoid	1	1.000	206	1.000	Domainoid score	I2807
eggNOG	1	0.900	-	-		E1_KOG3848
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	284	1.000	Inparanoid score	I2783
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1361987at2759
OrthoFinder	1	1.000	-	-		FOG0003589
OrthoInspector	1	1.000	-	-		otm44754
orthoMCL	1	0.900	-	-		OOG6_105338
Panther	1	1.100	-	-	O	PTHR13055
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2460
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760