DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(1)G0289 and plxdc1

DIOPT Version :9

Sequence 1:	NP_001303555.1	Gene:	l(1)G0289 / 31964	FlyBaseID:	FBgn0028331	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_005156181.1	Gene:	plxdc1 / 100286775	ZFINID:	ZDB-GENE-081104-391	Length:	465	Species:	Danio rerio

Alignment Length:	476	Identity:	160/476 - (33%)
Similarity:	218/476 - (45%)	Gaps:	85/476 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 KKPTLLGQSGNPKKVASSVVAATMTDPSPAVID--VDVSKVVDVPEEEIEAAVKNASLKESVDFH 216
            :|..:.|||......:|...........|.:::  :.:..:.|...:.:|            |..
Zfish    24 QKDFISGQSARTDGGSSDTQRTRRDRTGPQLLNNGLSIGTLPDNTTQVVE------------DSQ 76

  Fly   217 EYYNSVLY---ENKDEVASLWTELKAT---PENI--MLSSSHRRAMTVELKFDFPFYGHFVRNIT 273
            .||:...:   ||:.:  :||.:|.:.   |..:  :|||:||:|..|.|.||||||||.||.||
Zfish    77 RYYSWCSFGPGENRTK--NLWMDLDSVHLGPVRVHSILSSTHRQASRVALTFDFPFYGHQVRQIT 139

  Fly   274 VATGGFLYTGEYVHSWLAATQYIAPLMANFDTSMSNDSFVRLHDNGTAFTAVWENVTLQDKPDFG 338
            :|||||::||:..|..|.|||||||||||||.|.|..|.||..|||..|...|:.|.|:|:...|
Zfish   140 IATGGFIFTGDITHRMLTATQYIAPLMANFDPSYSKYSTVRYLDNGDTFVVQWDKVRLKDRETEG 204

  Fly   339 KFTFSVTLYQSGDIVFAYMLVPTNINSIQDKEHPVKVGLSDAYII---DKQLFFARRKTIYEYHR 400
            .|||...|.::|.|||.|..||..:..|...|||||||||||:|.   ..|...|::||||||||
Zfish   205 AFTFQTVLCRNGTIVFNYKDVPLPVEKINSTEHPVKVGLSDAFIALLSSPQSSDAKQKTIYEYHR 269

  Fly   401 VTFQQHEITNNTIIKLAAQPTCLGYNDCNSCINHNTTFTCLWCSVLNRCSTGTDRKKHEWLQMGC 465
            |.....:|.||:..:....||||.:..|..|:..|.|..|.||:.|.|||.|.||.:.||:...|
Zfish   270 VEIDTTKIVNNSAFEFTPLPTCLQHTTCKQCLQSNITSGCGWCNTLQRCSDGIDRYRQEWMDHNC 334

  Fly   466 EATAIHTSSLCPALGDKGNNAAGQGK-NGSANSGASANGATNTSTSSSGSSTPVTEPSVMST--- 526
            ...|                   :|| :..|:.|..::.:.....|.|.:.:||..|:...|
Zfish   335 FEEA-------------------KGKCDDYAHGGPESSNSPFRLPSPSIAPSPVARPASPMTEGE 380

  Fly   527 -RAPHATAYIKPGVDHSSDIHADGKVGNAELSKAEADNKNVGVAFGFMVPICLVFAVTLWLFYAY 590
             ..|..||.|                              .||....   |.|||...|.::|..
Zfish   381 EEVPEHTAII------------------------------AGVVAAL---ILLVFLTLLAVYYIN 412

  Fly   591 RNPHTKSGQLLIQFRPSQWSW 611
            .:|.......|:|.|.:.: |
Zfish   413 THPTVAPPFYLMQRRGNNY-W 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0289	NP_001303555.1	PSI	421..477	CDD:279745	21/55 (38%)
plxdc1	XP_005156181.1	PSI	291..334	CDD:214655	18/42 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574678
Domainoid	1	1.000	207	1.000	Domainoid score	I2828
eggNOG	1	0.900	-	-		E1_KOG3848
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	276	1.000	Inparanoid score	I2919
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1361987at2759
OrthoFinder	1	1.000	-	-		FOG0003589
OrthoInspector	1	1.000	-	-		otm26556
orthoMCL	1	0.900	-	-		OOG6_105338
Panther	1	1.100	-	-	O	PTHR13055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5819
SonicParanoid	1	1.000	-	-		X2460
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790