DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15306 and MAPRE1

DIOPT Version :9

Sequence 1:	NP_001259403.1	Gene:	CG15306 / 31961	FlyBaseID:	FBgn0030191	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_036457.1	Gene:	MAPRE1 / 22919	HGNCID:	6890	Length:	268	Species:	Homo sapiens

Alignment Length:	142	Identity:	64/142 - (45%)
Similarity:	88/142 - (61%)	Gaps:	8/142 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 HNVTVTHNSLVQWSRGDILDWFNETLQCNLINIEQLCTGAAYCNLMHMLYPKLINLKRVKFFSNQ 71
            ::.:||.::|   ||.|:|.|.||:||.||..|||||:|||||..|.||:|..|.||:|||.:..
Human     6 YSTSVTSDNL---SRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKL 67

  Fly    72 EYEYVNNFKELQKAFNKVNVSLPAEVNDLIKGHRVENFKFAVWFRHFFNVNHT-KDKCAGYDALV 135
            |:||:.|||.||..|.::.|.....|:.|:||...:||:|..||:.||:.|:. ||    ||.:.
Human    68 EHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKD----YDPVA 128

  Fly   136 ARDHQNIGIGSS 147
            ||..|...:..|
Human   129 ARQGQETAVAPS 140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15306	NP_001259403.1	CH	20..103	CDD:278723	43/82 (52%)
MAPRE1	NP_036457.1	BIM1	16..257	CDD:227542	61/129 (47%)
		Interaction with MTUS2/TIP150. /evidence=ECO:0000269\|PubMed:19543227	124..268		6/17 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..187
		Interaction with CDK5RAP2. /evidence=ECO:0000269\|PubMed:19553473	185..268
		DCTN1-binding	208..268
		APC-binding	220..242
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158827
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5217
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1237523at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.810