DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gip and Hyi

DIOPT Version :9

Sequence 1:	NP_511106.1	Gene:	Gip / 31960	FlyBaseID:	FBgn0011770	Length:	264	Species:	Drosophila melanogaster
Sequence 2:	XP_002729578.2	Gene:	Hyi / 500536	RGDID:	1561416	Length:	277	Species:	Rattus norvegicus

Alignment Length:	263	Identity:	95/263 - (36%)
Similarity:	159/263 - (60%)	Gaps:	11/263 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LKFAANLNFLFTERATSIAERIRLAHQNGFRAVEIPYPEGETSD-VVSAVKETGVVVSLVNLAFD 66
            |:|:||:::||.| ...:.||:..|.:.||.|.|:.:|..|:.. :.||.:..|:.:.|:|.  .
  Rat     4 LRFSANVSWLFPE-LPGVPERLHAAGRAGFEAAEVAWPYAESPQALASAARAAGLRLVLINT--P 65

  Fly    67 KSD-DQLRFGSTSVPGSEKLFRSQLDATIDFARQVNCGKIHLTAGLFKGGQESDYTK-----TYT 125
            :.| ::...|..:|||.:..||..|:..:.:|:.:.|.:|||.||....|.:.:..|     .:.
  Rat    66 RGDHEKGEMGLGAVPGRQAAFREGLEQAVLYAKALGCPRIHLMAGRVPRGADREAVKGEMETVFV 130

  Fly   126 ANLKIAADSLRASKMIGVIEPIN-KYAVPGYYMNSYSKAAGILADVAADNIQLLADLYHLQHLHG 189
            .||:.||:.|....::|::|||| :...|.|::::..:||.||..|...|:||..|::|.|.:.|
  Rat   131 ENLRHAAEVLAQENLVGLLEPINTRITDPQYFLDTPQQAAAILQKVGRPNLQLQMDIFHWQVMDG 195

  Fly   190 NVSKTLEEYKALIGHFQIAQVPHRHEPDVSGELDYGFVFKALQEFGYDGWIGCEYKPKTTTVEGL 254
            |::..:.|:..::||.|:||||.|.||..|||||:.::|:.|::.||.|::||||:|:..|||||
  Rat   196 NLTGNIREFLPIVGHVQVAQVPDRGEPGSSGELDFTYLFQLLEDEGYQGFVGCEYRPRGDTVEGL 260

  Fly   255 GWV 257
            .|:
  Rat   261 SWL 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gip	NP_511106.1	OH-pyruv-isom	4..256	CDD:163190	93/259 (36%)
Gip	NP_511106.1	AP_endonuc_2	24..222	CDD:279585	67/205 (33%)
Hyi	XP_002729578.2	Hyi	3..266	CDD:226149	95/263 (36%)
Hyi	XP_002729578.2	AP_endonuc_2	24..223	CDD:279585	64/200 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346691
Domainoid	1	1.000	108	1.000	Domainoid score	I6361
eggNOG	1	0.900	-	-		E1_COG3622
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12824
Inparanoid	1	1.050	180	1.000	Inparanoid score	I3907
OMA	1	1.010	-	-		QHG52228
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005694
OrthoInspector	1	1.000	-	-		oto95664
orthoMCL	1	0.900	-	-		OOG6_106707
Panther	1	1.100	-	-	LDO	PTHR43489
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4089
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760