DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ia and MNL2

DIOPT Version :9

Sequence 1:	NP_727408.2	Gene:	alpha-Man-Ia / 31957	FlyBaseID:	FBgn0259170	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_013158.1	Gene:	MNL2 / 850746	SGDID:	S000004047	Length:	849	Species:	Saccharomyces cerevisiae

Alignment Length:	824	Identity:	150/824 - (18%)
Similarity:	259/824 - (31%)	Gaps:	312/824 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 NDSGPS------SAPASSTLGS---SSTG-PRILQAAEALMEGNVDSISLPAAAPLTAATTSSAK 179
            |||.||      :...||.|..   |||| .||....|   .||| ::.|...|.|.........
Yeast    45 NDSLPSINNYEHNTEGSSKLDPPDLSSTGSDRIATDKE---NGNV-AVDLSDPATLREKNKYFPL 105

  Fly   180 SLENSQ---GSDTPHSHANT-----------TNADITMGIADHNPGGIQ--------FERRAHVK 222
            .|:.|.   ||:.|.|...|           ::..:| .|:.::...||        .:....:|
Yeast   106 LLKGSSHQIGSNLPISSLLTYKEKYPVLFEYSSPSLT-SISQNDVHKIQPAMQLPPDVDMIKQIK 169

  Fly   223 QMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYDLGATIVDGLDTLYIMGLEKEYREGRDWI 287
            .:...:|:..:|..  |:.||..|..|            ..::|.|||||:.|..|.:::..:.|
Yeast   170 DIFMKSWNQEQLLL--KSNLRRESTWP------------IDLIDSLDTLYLCGETKLFQDSVNII 220

  Fly   288 ER-KFSLDNISAE-LSVFETNIRFVGGMLTLYAFTGDPLYKEKAQHVADKLLPAFQTPTGIPYAL 350
            |. .|.:..::.| :.:.:...|.:.|:|:.|..:.|.....||:||||.:|.:|.||..||...
Yeast   221 EDFDFRVPPLAMEVIDIPDITTRVLEGLLSAYELSMDKRLLNKAKHVADFILRSFDTPNRIPILK 285

  Fly   351 VNTKTGVAKNYGWASGGSSILSEFGTLHLEFAYLSDITGNPLYRERVQ----TIRQVLKEIEKP- 410
            ...|:.:...:...:..|..|:   |:.|.|..||.:|....|.:.|:    ||||...|.:..
Yeast   286 YFWKSDLRNRFPDRTVPSGQLT---TMALAFIRLSQLTRLNKYFDAVERVFTTIRQSYNEFDMEF 347

  Fly   411 -------------------------------KGLYPN-----------FLNP------------- 420
                                           |.:..|           ||||
Yeast   348 MLPDVVDASGCQLLTQEEIENGAHLKGSSIMKSINENFKFVHCQQLGKFLNPPIDDNSLQEQSQY 412

  Fly   421 ----------------------------------KTGKWGQLHMSLGALGDSYYEYLLKAWLQSG 451
                                              |......:..|:|:..::..|.:.|...:.|
Yeast   413 QAYRINEKTVPILENLFKINDLFQSSYDILDGSSKNANAATMDPSIGSEVEAVDEIIEKRNFKDG 477

  Fly   452 -QTDEEAREMFDEAM----------LAILDKMVRTSPGGLTYVSDLKFD---------------- 489
             :.|.....:.|:::          ::.:.|.:...|.......:.||:
Yeast   478 TKKDSTKNTVGDKSLIDSQTFLTNSISNIFKFMTFRPMLPKQTENKKFNFLNSILTKSQFMPTTN 542

  Fly   490 ------RLEHKMDHLACFSGGLFALGAATR---QNDYTDKY------MEVGKGITNTC------- 532
                  |..:.:...:|..||:  ||.::|   :.....||      :|:.:.||.:|
Yeast   543 ELDVTIRKSYDVSLYSCRLGGI--LGLSSRVPHRGGVNTKYILPSSLLEMSEIITESCFMLMEEF 605

  Fly   533 ------------------------------------HESY------------------------- 536
                                                :|::
Yeast   606 DGLLPQKFELDPCTDETNGNCEFNGETKSRMIANGEYETFENDLDVGIKVSNYGKGGNDQKAKRN 670

  Fly   537 ------------IRAPTQLGPEAFRFSEAVEARALR--------------------SQEKYY--- 566
                        |:..|....::....:..|...:|                    ||.|.:
Yeast   671 VLSKDGITETQNIKGDTVGSSKSIAEIDGDEVTQIRRVFTLGKDIKPHITTDDTMGSQWKNHPDW 735

  Fly   567 -----------ILRPETFESYFVLWRLTHDQKYRDWGWEAVLALEKHCRT----AHGYCGLRNVY 616
                       :|.....||.|.::|::.:||:|..|.::...|.:....    |.|...::..|
Yeast   736 PFWVNKVESRRLLDSNIIESIFYMYRISGEQKWRSMGKQSFGILMQELMELNSGAKGLWQIKEFY 800

  Fly   617 QQEPQKDDVQQSFFLAETLKYLYLLFSDDSVLPLDEWVFNTEAH 660
            :...:.::...|::.:.||||..|||||...:.||:.:.....|
Yeast   801 ENGEKVNNDLPSYWFSRTLKYYLLLFSDGDKVSLDKHILTQGGH 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ia	NP_727408.2	Glyco_hydro_47	224..664	CDD:279825	117/693 (17%)
MNL2	NP_013158.1	LanC_like	197..848	CDD:414247	110/653 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11742
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X635
TreeFam	0	0.000	Not matched by this tool.
	4	3.910