Protein Alignment alpha-Man-Ia and EDEM3

DIOPT Version :10

• Sequence 1: NP_727408.2
• Gene: alpha-Man-Ia / 31957
• FlyBaseID: FBgn0259170
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_001306889.1
• Gene: EDEM3 / 80267
• HGNCID: 16787
• Length: 948
• Species: Homo sapiens
• Alignment Length: 486
• Identity: 156/486 - (32%)
• Similarity: 232/486 - (47%)
• Gaps: 85/486 - (17%)

  Fly   221 VKQMMEHAWHNYKLYAWGKNELRPLS-------QRPHSASI---FGSYDLGATIVDGLDTLYIMG 275
            |.:|.:||:.||..:|:..:||.||:       |.|....:   .|.:.|  |::|.||||.::.
Human    56 VLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSL--TLIDSLDTLVVLN 118

  Fly   276 LEKEYREGRDWIERKFSLDNISAELSVFETNIRFVGGMLTLYAFTGDPLYKEK------------ 328
            ..||:.:....:.|..:||| ...:||||||||.:||:|..::..  .:.|||
Human   119 KTKEFEDAVRKVLRDVNLDN-DVVVSVFETNIRVLGGLLGGHSLA--IMLKEKGEYMQWYNDELL 180

  Fly   329 --AQHVADKLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGS---SILSEFGTLHLEFAYLSDIT 388
              |:.:..||||||.|.:|:||..:|.|.|:.|..  |..|:   :..:..|||.||||.||..|
Human   181 QMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPE--ARTGTETDTCTACAGTLILEFAALSRFT 243

  Fly   389 GNPLYRERVQTIRQVL-KEIEKPKGLYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKAWLQSGQ 452
            |..::.|..:.....| ::.::...|....:|..||.|.:....:||..||||||||||::..|
Human   244 GATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLG- 307

  Fly   453 TDEEAREMFDEAMLAILDKMVRTSPGGLTYVSD--LKFDRLEHK--------MDHLACFSGGLFA 507
             |:...|.|:....||           :.|:|.  |..|...||        ||.|..|..||..
Human   308 -DDSFLERFNTHYDAI-----------MRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQV 360

  Fly   508 LGAATRQNDYTDK--YMEVGKGITNTCHESYIRAPTQLGPEAFRFSEAVEARALRSQEKYYILRP 570
            |....|....|.:  |..:.|       .:::       ||||    ..:.|...:|   :.|||
Human   361 LKGDIRPAIETHEMLYQVIKK-------HNFL-------PEAF----TTDFRVHWAQ---HPLRP 404

  Fly   571 ETFESYFVLWRLTHDQKYRDWGWEAVLALEKHCRTAHGYCGLRNVYQQEPQKDDVQQSFFLAETL 635
            |..||.:.|::.|.|..|.:.|...:..|.|:.|...|:..:::|  :....:|...||||||..
Human   405 EFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDV--RTGSHEDRMDSFFLAEMF 467

  Fly   636 KYLYLLFSD--DSVLPLDEWVFNTEAHPLPI 664
            |||||||:|  |.:..:::::|.||||.||:
Human   468 KYLYLLFADKEDIIFDIEDYIFTTEAHLLPL 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ia	NP_727408.2	LanC_like	216..664	CDD:471159	155/484 (32%)
EDEM3	NP_001306889.1	Glyco_hydro_47	59..498	CDD:460241	154/481 (32%)
		PA_EDEM3_like	664..789	CDD:239041
		PRK08581	<809..>936	CDD:236304
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	945..948