DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ia and Edem3

DIOPT Version :9

Sequence 1:	NP_727408.2	Gene:	alpha-Man-Ia / 31957	FlyBaseID:	FBgn0259170	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	XP_006529858.1	Gene:	Edem3 / 66967	MGIID:	1914217	Length:	948	Species:	Mus musculus

Alignment Length:	486	Identity:	156/486 - (32%)
Similarity:	232/486 - (47%)	Gaps:	85/486 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 VKQMMEHAWHNYKLYAWGKNELRPLS-------QRPHSASI---FGSYDLGATIVDGLDTLYIMG 275
            |.:|.:||:.||..:|:..:||.||:       |.|....:   .|.:.|  |::|.||||.::.
Mouse    57 VLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSL--TLIDSLDTLVVLN 119

  Fly   276 LEKEYREGRDWIERKFSLDNISAELSVFETNIRFVGGMLTLYAFTGDPLYKEKAQH--------- 331
            ..||:.:....:.|..:||| ...:||||||||.:||:|..::..  .:.|||.:|
Mouse   120 KTKEFEDAVRKVLRDVNLDN-DVVVSVFETNIRVLGGLLGGHSLA--IMLKEKGEHMQWYNDELL 181

  Fly   332 -----VADKLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGS---SILSEFGTLHLEFAYLSDIT 388
                 :..||||||.|.:|:||..:|.|.|:.|..  |..|:   :..:..|||.||||.||..|
Mouse   182 HMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPE--ARTGTETDTCTACAGTLILEFAALSRFT 244

  Fly   389 GNPLYRERVQTIRQVL-KEIEKPKGLYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKAWLQSGQ 452
            |..::.|..:.....| ::.::...|....:|..||.|.:....:||..||||||||||::..|
Mouse   245 GATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLG- 308

  Fly   453 TDEEAREMFDEAMLAILDKMVRTSPGGLTYVSD--LKFDRLEHK--------MDHLACFSGGLFA 507
             |:...|.|:....||           :.|:|.  |..|...||        ||.|..|..||..
Mouse   309 -DDSFLERFNTHYDAI-----------MRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQV 361

  Fly   508 LGAATRQNDYTDK--YMEVGKGITNTCHESYIRAPTQLGPEAFRFSEAVEARALRSQEKYYILRP 570
            |....|....|.:  |..:.|       .:::       ||||    ..:.|...:|   :.|||
Mouse   362 LKGDIRPAIETHEMLYQVIKK-------HNFL-------PEAF----TTDFRVHWAQ---HPLRP 405

  Fly   571 ETFESYFVLWRLTHDQKYRDWGWEAVLALEKHCRTAHGYCGLRNVYQQEPQKDDVQQSFFLAETL 635
            |..||.:.|::.|.|..|.:.|...:..|.|:.|...|:..:::|  :....:|...||||||..
Mouse   406 EFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDV--RTGSHEDRMDSFFLAEMF 468

  Fly   636 KYLYLLFSD--DSVLPLDEWVFNTEAHPLPI 664
            |||||||:|  |.:..:::::|.||||.||:
Mouse   469 KYLYLLFADKEDIIFDIEDYIFTTEAHLLPL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ia	NP_727408.2	Glyco_hydro_47	224..664	CDD:279825	154/481 (32%)
Edem3	XP_006529858.1	Glyco_hydro_47	60..499	CDD:366693	154/481 (32%)
		PA_EDEM3_like	666..791	CDD:239041
		DUF4521	821..>914	CDD:373483
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839759
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840