DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ia and MAN1C1

DIOPT Version :9

Sequence 1:	NP_727408.2	Gene:	alpha-Man-Ia / 31957	FlyBaseID:	FBgn0259170	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001372111.1	Gene:	MAN1C1 / 57134	HGNCID:	19080	Length:	664	Species:	Homo sapiens

Alignment Length:	628	Identity:	277/628 - (44%)
Similarity:	380/628 - (60%)	Gaps:	100/628 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 QQPN-KIVIEI-----GLSNDSGPSSAPASSTLGSSS-------------------TGPRILQAA 151
            |||. ::|.||     ....:..|:.|||:...|...                   ||||  :.|
Human    59 QQPGLEVVAEIAGHAPAREQEPPPNPAPAAPAPGEDDPSSWASPRRRKGGLRRTRPTGPR--EEA 121

  Fly   152 EALMEGNVDSISLPAAAPLTAATTSSAKSLENSQG-----------SDTPHSHANTTNADITMGI 205
            .| ..||    |:||:.|             ..:|           |...|.... |.||
Human   122 TA-ARGN----SIPASRP-------------GDEGVPFRFDFNAFRSRLRHPVLG-TRAD----- 162

  Fly   206 ADHNPGGIQFERRAHVKQMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYD----------- 259
            ....|......:|..:|:||:.||.:||.||.||||||||::..:..::||:..
Human   163 ESQEPQSQVRAQREKIKEMMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFGANPSGEDRVAGKAD 227

  Fly   260 ----------------------LGATIVDGLDTLYIMGLEKEYREGRDWIERKFSLDNISAELSV 302
                                  .|||::|.|||||:|.|::|::|.:.|:...|.| |:|.|.|:
Human   228 PCVMPLVMKAGENQRRQGDRGLSGATVIDSLDTLYLMELKEEFQEAKAWVGESFHL-NVSGEASL 291

  Fly   303 FETNIRFVGGMLTLYAFTGDPLYKEKAQHVADKLLPAFQTPTGIPYALVNTKTGVAKNYGWA-SG 366
            ||.|||::||:|:.:..||:.:::.||..:.:||||||.||||||..:|:.|:|   |:||| :|
Human   292 FEVNIRYIGGLLSAFYLTGEEVFRIKAIRLGEKLLPAFNTPTGIPKGVVSFKSG---NWGWATAG 353

  Fly   367 GSSILSEFGTLHLEFAYLSDITGNPLYRERVQTIRQVLKEIEKPKGLYPNFLNPKTGKWGQLHMS 431
            .||||:|||:|||||.:|::::||.::.|:|:.||:||::||||.|||||||:|.:|.|.|.|:|
Human   354 SSSILAEFGSLHLEFLHLTELSGNQVFAEKVRNIRKVLRKIEKPFGLYPNFLSPVSGNWVQHHVS 418

  Fly   432 LGALGDSYYEYLLKAWLQSGQTDEEAREMFDEAMLAILDKMVRTSPGGLTYVSDLKFDRLEHKMD 496
            :|.||||:||||:|:||.||:||.||:.|:.||:.||...::..|||||||:::.:...|:|||.
Human   419 VGGLGDSFYEYLIKSWLMSGKTDMEAKNMYYEALEAIETYLLNVSPGGLTYIAEWRGGILDHKMG 483

  Fly   497 HLACFSGGLFALGAATRQNDYTDKYMEVGKGITNTCHESYIRAPTQLGPEAFRFSEAVEARALRS 561
            ||||||||:.||||...:.:....|.|:...||.||||||.|:.|:||||||.|:...||.|.:.
Human   484 HLACFSGGMIALGAEDAKEEKRAHYRELAAQITKTCHESYARSDTKLGPEAFWFNSGREAVATQL 548

  Fly   562 QEKYYILRPETFESYFVLWRLTHDQKYRDWGWEAVLALEKHCRTAHGYCGLRNVYQQEPQKDDVQ 626
            .|.|||||||..|||..|||.||:..||:||||.||||||:|||..|:.|:::||...|..|:.|
Human   549 SESYYILRPEVVESYMYLWRQTHNPIYREWGWEVVLALEKYCRTEAGFSGIQDVYSSTPNHDNKQ 613

  Fly   627 QSFFLAETLKYLYLLFSDDSVLPLDEWVFNTEAHPLPIKGANA 669
            |||||||||||||||||:|.:|.|::|||||||||||:..:::
Human   614 QSFFLAETLKYLYLLFSEDDLLSLEDWVFNTEAHPLPVNHSDS 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ia	NP_727408.2	Glyco_hydro_47	224..664	CDD:279825	244/473 (52%)
MAN1C1	NP_001372111.1	Glyco_hydro_47	181..651	CDD:396217	244/473 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149705
Domainoid	1	1.000	571	1.000	Domainoid score	I224
eggNOG	1	0.900	-	-		E1_KOG2204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54359
OrthoDB	1	1.010	-	-		D263455at33208
OrthoFinder	1	1.000	-	-		FOG0001280
OrthoInspector	1	1.000	-	-		otm41456
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	1	1.100	-	-	O	PTHR11742
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X635
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.720