DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ia and man1a1

DIOPT Version :9

Sequence 1:	NP_727408.2	Gene:	alpha-Man-Ia / 31957	FlyBaseID:	FBgn0259170	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	XP_694435.2	Gene:	man1a1 / 566078	ZFINID:	ZDB-GENE-041014-321	Length:	618	Species:	Danio rerio

Alignment Length:	463	Identity:	268/463 - (57%)
Similarity:	348/463 - (75%)	Gaps:	5/463 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 GIADHNPGGIQFE-RRAHVKQMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYDLGATIVDG 267
            |...|.|.....: :||.:|:||:.||.|||.||||.|||||:|::.||:::|||.. ||||||.
Zfish   146 GATGHEPADPDIKAKRAKIKEMMQFAWDNYKHYAWGSNELRPVSKQGHSSNLFGSLK-GATIVDA 209

  Fly   268 LDTLYIMGLEKEYREGRDWIERKFSLD-NISAELSVFETNIRFVGGMLTLYAFTGDPLYKEKAQH 331
            |||||||.:..|:....:|:|:  :|| |::||:||||.|||||||:|:.|..:|..::::||..
Zfish   210 LDTLYIMEMYDEFEAATEWVEK--NLDFNMNAEISVFEVNIRFVGGLLSAYYLSGKEVFRKKAVE 272

  Fly   332 VADKLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSEFGTLHLEFAYLSDITGNPLYRER 396
            :.:||||||:||||:|:||:|.|:||.:|:.|||||||||:|:|||||||.:||.::|.|::.|:
Zfish   273 LGEKLLPAFKTPTGVPWALLNLKSGVGRNWPWASGGSSILAEYGTLHLEFMHLSALSGRPVFAEK 337

  Fly   397 VQTIRQVLKEIEKPKGLYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKAWLQSGQTDEEAREMF 461
            |..||:||..::||:|||||:|||.:|:|||.|:|:|.||||:|||||||||.|.:.|||.::::
Zfish   338 VMNIRKVLTRLDKPQGLYPNYLNPNSGQWGQHHVSVGGLGDSFYEYLLKAWLMSDKIDEEGKKLY 402

  Fly   462 DEAMLAILDKMVRTSPGGLTYVSDLKFDRLEHKMDHLACFSGGLFALGAATRQNDYTDKYMEVGK 526
            .:|:.||...::|.|.|||||:::.|...|||||.||.||:||:.||||....::.|...||:..
Zfish   403 YDALQAIEKNLIRKSSGGLTYIAEWKGGLLEHKMGHLTCFAGGMIALGADGAPDEKTGHQMELAA 467

  Fly   527 GITNTCHESYIRAPTQLGPEAFRFSEAVEARALRSQEKYYILRPETFESYFVLWRLTHDQKYRDW 591
            .|..||||||:|...:||||||||...|||.|.|..|||:|||||..|:|..:||.|||.|||.|
Zfish   468 EIARTCHESYVRTNLKLGPEAFRFDGGVEAIATRQNEKYFILRPEVIETYMYMWRFTHDPKYRQW 532

  Fly   592 GWEAVLALEKHCRTAHGYCGLRNVYQQEPQKDDVQQSFFLAETLKYLYLLFSDDSVLPLDEWVFN 656
            |||||.|||||||...||.|:|:||...|..|||||||:|||||||||||||||..||.|.||||
Zfish   533 GWEAVQALEKHCRVEGGYSGVRDVYSNNPNHDDVQQSFYLAETLKYLYLLFSDDDHLPFDHWVFN 597

  Fly   657 TEAHPLPI 664
            |||||||:
Zfish   598 TEAHPLPV 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ia	NP_727408.2	Glyco_hydro_47	224..664	CDD:279825	261/440 (59%)
man1a1	XP_694435.2	Glyco_hydro_47	167..605	CDD:279825	261/440 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583847
Domainoid	1	1.000	573	1.000	Domainoid score	I212
eggNOG	1	0.900	-	-		E1_KOG2204
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	601	1.000	Inparanoid score	I917
OMA	1	1.010	-	-		QHG54359
OrthoDB	1	1.010	-	-		D263455at33208
OrthoFinder	1	1.000	-	-		FOG0001280
OrthoInspector	1	1.000	-	-		otm26462
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	1	1.100	-	-	O	PTHR11742
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R728
SonicParanoid	1	1.000	-	-		X635
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800