DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Man-Ia and si:ch211-282j22.3

DIOPT Version :9

Sequence 1:	NP_727408.2	Gene:	alpha-Man-Ia / 31957	FlyBaseID:	FBgn0259170	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	XP_003200881.1	Gene:	si:ch211-282j22.3 / 562939	ZFINID:	ZDB-GENE-091113-49	Length:	837	Species:	Danio rerio

Alignment Length:	479	Identity:	160/479 - (33%)
Similarity:	227/479 - (47%)	Gaps:	61/479 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 ERRAHVKQMMEHAWHNYKLYAWGKNELRPLSQR-------PHSASI---FGSYDLGATIVDGLDT 270
            |.|..:.:|.:||:::|..||:..:||.|||.|       |:...:   .|.:.|  |::|.|||
Zfish    47 EIRDQILEMFDHAYNSYMDYAYPADELMPLSCRGRVRGLEPNRGDVDDSLGKFSL--TLIDTLDT 109

  Fly   271 LYIMGLEKEYREGRDWIERKFSLDNISAELSVFETNIRFVGGMLTLYAFTGDPL---------YK 326
            |.::....|:.|....|.|...||| ...:||||||||.:||:|..:.. .|.|         |:
Zfish   110 LVLLNKLDEFEEAVKKIMRDVRLDN-DIVVSVFETNIRVLGGLLGAHVM-ADVLKQRGQRMQWYR 172

  Fly   327 EKAQHVAD----KLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSE-FGTLHLEFAYLSD 386
            ::..|:|.    :|||||.|.:|:||..||.:.||..........|...:. .|||.||||.||.
Zfish   173 DELLHMAKELGYRLLPAFNTTSGLPYPRVNLRYGVVNPLSRTGTESDTCTACAGTLILEFAALSR 237

  Fly   387 ITGNPLYRERVQTIRQVLKEIEKPKG--LYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKAWLQ 449
            ::|:.::.|..:....||.| ::.:|  |....:|...|.|.:....:||..|||||||:||::.
Zfish   238 MSGDTIFEEHARKAMDVLWE-KRQRGSDLVGTVINIHNGDWVRRDSGVGAGIDSYYEYLMKAYIL 301

  Fly   450 SGQTDEEAREMFDEAMLAILDKMVRTSPGGLTYVSDLKFDRLEHKMDHLACFSGGLFALGAATRQ 514
            .|  |:...|.|:....||: |.:...|..|..........:...||.|..|..||..|....:.
Zfish   302 LG--DKVYLERFNTHYSAIM-KYISQPPLLLNVHMHNPTVNVRSWMDSLLAFFPGLQVLRGDLKP 363

  Fly   515 NDYTDKYMEVGKGITNTCHESYIRAPTQLG--PEAFRFSEAVEARALRSQEKYYILRPETFESYF 577
            ...|              ||...:...|..  ||||    ..|.|....|   :.||||..||.:
Zfish   364 AIET--------------HEMLYQVTKQHNFLPEAF----TTEFRVHWGQ---HPLRPEFAESTY 407

  Fly   578 VLWRLTHDQKYRDWGWEAVLALEKHCRTAHGYCGLRNVYQQEPQKDDVQQSFFLAETLKYLYLLF 642
            .|::.|.|..|...|...|..|..|.|...|:..:::|  :....:|...||||||..|||||||
Zfish   408 FLYKATGDPYYLKVGQSIVEKLNAHARVPCGFAAVQDV--RTGTHEDRMDSFFLAEMFKYLYLLF 470

  Fly   643 SDDSVLP--LDEWVFNTEAHPLPI 664
            |:.|.||  :|:::|.||||.||:
Zfish   471 SEKSQLPIDIDDYIFTTEAHLLPV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ia	NP_727408.2	Glyco_hydro_47	224..664	CDD:279825	157/469 (33%)
si:ch211-282j22.3	XP_003200881.1	Glyco_hydro_47	55..494	CDD:279825	157/469 (33%)
si:ch211-282j22.3	XP_003200881.1	PA_EDEM3_like	642..768	CDD:239041
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583843
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840