DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ia and Man1b1

DIOPT Version :9

Sequence 1:	NP_727408.2	Gene:	alpha-Man-Ia / 31957	FlyBaseID:	FBgn0259170	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001102666.1	Gene:	Man1b1 / 499751	RGDID:	1563595	Length:	657	Species:	Rattus norvegicus

Alignment Length:	597	Identity:	205/597 - (34%)
Similarity:	318/597 - (53%)	Gaps:	67/597 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 ATHPKNLQRQLQQQQQQQLQ------QQQPNKIVIEIGLSNDSGPSSAPASSTLGSSSTGPRILQ 149
            :..|:.....|.|::|:.|:      |.:|...|.:.|:.:|:....|    .||
  Rat   101 SAEPEGFADILSQKRQRHLRRGPPHLQIRPPNTVSKDGMQDDAKEREA----ALG---------- 151

  Fly   150 AAEALMEGNVDSISLPAAAPLTAATTSSAKS--LENSQGSDTPHSHANTTNADITMGIADHNPGG 212
              :|..|.|            |..|..|.:.  :|..|.::.|...|..:...:.:.........
  Rat   152 --KAQQEEN------------TQRTVISWRGAVIEPEQATEPPSKRAEASIKPLFLASRIWKEPA 202

  Fly   213 IQFERRAHVKQMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYDLGATIVDGLDTLYIMGLE 277
            ...||:..|.:...|||..|:.:|||.:||:|:|:.  .:..||   ||.|::|.|||::|:||:
  Rat   203 PPNERQKGVIEAFLHAWKGYQKFAWGHDELKPVSKT--FSEWFG---LGLTLIDALDTMWILGLK 262

  Fly   278 KEYREGRDWIERKFSLDNISAELSVFETNIRFVGGMLTLYAFTGDPLYKEKAQHVADKLLPAFQT 342
            :|::|.|.|:........ :.::::||:.||.:||:|:.|..:||.|:..||:...::|:|||.|
  Rat   263 QEFKEARKWVSENLDFQK-NVDVNLFESTIRILGGLLSAYHLSGDSLFLSKAEDFGNRLMPAFTT 326

  Fly   343 PTGIPYALVNTKTGVAKNYGWASGGSSILSEFGTLHLEFAYLSDITGNPLYRERVQTIRQVLKEI 407
            |:.|||:.||..||.|.:..|.|  .|.::|..::.|||..||.:||...::|.|:.:.:.:..:
  Rat   327 PSKIPYSDVNIGTGFAHSPQWTS--DSTVAEVTSIQLEFRELSRLTGIKKFQEAVEEVTKHIHSL 389

  Fly   408 E-KPKGLYPNFLNPKTGKWGQLH---MSLGALGDSYYEYLLKAWLQSGQTDEEAREMFDEAMLAI 468
            . |..||.|.|:|..:|.:  .|   .:|||..|||||||||.|:|.|:.:.:..|.:..|:..|
  Rat   390 SGKKDGLVPMFINTNSGLF--THPGVFTLGARADSYYEYLLKQWIQGGKKETQLLEDYVRAIEGI 452

  Fly   469 LDKMVRTS-PGGLTYVSDLKFDRLEHKMDHLACFSGGLFALGAATRQNDYTDKYMEVGKGITNTC 532
            ...::|.| |..||:|.:|...|...|||||.||..|..|||.   .:.....:|::.:.:..||
  Rat   453 KAHLLRQSQPRKLTFVGELAHGRFSAKMDHLVCFLPGTLALGV---HHGLPADHMDLARALMETC 514

  Fly   533 HESYIRAPTQLGPEAFRFS-------EAVEARALRSQEKYYILRPETFESYFVLWRLTHDQKYRD 590
            ::...:..|.|.||...|:       :.||   ::..:::.:|||||.||.|.|:|:|.|:||:|
  Rat   515 YQMNQQMETGLSPEIAHFNMYPRADHKDVE---VKPADRHNLLRPETVESLFYLYRVTKDRKYQD 576

  Fly   591 WGWEAVLALEKHCRT-AHGYCGLRNVY-QQEPQKDDVQQSFFLAETLKYLYLLFSDD-SVLPLDE 652
            ||||.:.:..|:.|. :.||..:.||. ..:|:..|..:|||:.||||||||||||| .:|.||.
  Rat   577 WGWEILQSFNKYTRVPSGGYSSINNVQNSHKPEPRDKMESFFVGETLKYLYLLFSDDLELLGLDT 641

  Fly   653 WVFNTEAHPLPI 664
            .|||||||||||
  Rat   642 CVFNTEAHPLPI 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ia	NP_727408.2	Glyco_hydro_47	224..664	CDD:279825	177/454 (39%)
Man1b1	NP_001102666.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..157		10/54 (19%)
Man1b1	NP_001102666.1	Glyco_hydro_47	214..653	CDD:279825	177/454 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54359
OrthoDB	1	1.010	-	-		D263455at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830