DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ia and MAN1A1

DIOPT Version :9

Sequence 1:	NP_727408.2	Gene:	alpha-Man-Ia / 31957	FlyBaseID:	FBgn0259170	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	XP_005267043.1	Gene:	MAN1A1 / 4121	HGNCID:	6821	Length:	736	Species:	Homo sapiens

Alignment Length:	464	Identity:	270/464 - (58%)
Similarity:	349/464 - (75%)	Gaps:	5/464 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 MGIADHNPGGIQF-ERRAHVKQMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYDLGATIVD 266
            :|:....|..... |:||.:|:||:|||:|||.||||.|||:|:|:..||:|:||:.. ||||||
Human   263 IGVESREPADAAIREKRAKIKEMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNIK-GATIVD 326

  Fly   267 GLDTLYIMGLEKEYREGRDWIERKFSLD-NISAELSVFETNIRFVGGMLTLYAFTGDPLYKEKAQ 330
            .||||:||.::.|:.|.:.|:|.  :|| |::||:||||.|||||||:|:.|..:|:.::::||.
Human   327 ALDTLFIMEMKHEFEEAKSWVEE--NLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEEIFRKKAV 389

  Fly   331 HVADKLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSEFGTLHLEFAYLSDITGNPLYRE 395
            .:..||||||.||:|||:||:|.|:|:.:|:.|||||||||:|||||||||.:||.::|||::.|
Human   390 ELGVKLLPAFHTPSGIPWALLNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHLSHLSGNPIFAE 454

  Fly   396 RVQTIRQVLKEIEKPKGLYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKAWLQSGQTDEEAREM 460
            :|..||.||.::|||:|||||:|||.:|:|||.|:|:|.||||:|||||||||.|.:||.||::|
Human   455 KVMNIRTVLNKLEKPQGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDLEAKKM 519

  Fly   461 FDEAMLAILDKMVRTSPGGLTYVSDLKFDRLEHKMDHLACFSGGLFALGAATRQNDYTDKYMEVG 525
            :.:|:.||...::|.|..||||:::.|...|||||.||.||:||:|||||..........|:|:|
Human   520 YFDAVQAIETHLIRKSSSGLTYIAEWKGGLLEHKMGHLTCFAGGMFALGADAAPEGMAQHYLELG 584

  Fly   526 KGITNTCHESYIRAPTQLGPEAFRFSEAVEARALRSQEKYYILRPETFESYFVLWRLTHDQKYRD 590
            ..|..||||||.|...:||||||||...|||.|.|..|||||||||..|:|..:||||||.|||.
Human   585 AEIARTCHESYNRTFMKLGPEAFRFDGGVEAIATRQNEKYYILRPEVMETYMYMWRLTHDPKYRK 649

  Fly   591 WGWEAVLALEKHCRTAHGYCGLRNVYQQEPQKDDVQQSFFLAETLKYLYLLFSDDSVLPLDEWVF 655
            |.||||.|||.|||...||.|||:||......||||||||||||||||||:||||.:|||:.|:|
Human   650 WAWEAVEALENHCRVNGGYSGLRDVYLLHESYDDVQQSFFLAETLKYLYLIFSDDDLLPLEHWIF 714

  Fly   656 NTEAHPLPI 664
            |:|||.|||
Human   715 NSEAHLLPI 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ia	NP_727408.2	Glyco_hydro_47	224..664	CDD:279825	262/440 (60%)
MAN1A1	XP_005267043.1	Glyco_hydro_47	285..723	CDD:279825	262/440 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149709
Domainoid	1	1.000	571	1.000	Domainoid score	I224
eggNOG	1	0.900	-	-		E1_KOG2204
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	598	1.000	Inparanoid score	I963
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54359
OrthoDB	1	1.010	-	-		D263455at33208
OrthoFinder	1	1.000	-	-		FOG0001280
OrthoInspector	1	1.000	-	-		otm41456
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	1	1.100	-	-	O	PTHR11742
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R728
SonicParanoid	1	1.000	-	-		X635
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800