DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ia and Edem2

DIOPT Version :9

Sequence 1:	NP_727408.2	Gene:	alpha-Man-Ia / 31957	FlyBaseID:	FBgn0259170	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_609611.1	Gene:	Edem2 / 34714	FlyBaseID:	FBgn0032480	Length:	801	Species:	Drosophila melanogaster

Alignment Length:	596	Identity:	170/596 - (28%)
Similarity:	267/596 - (44%)	Gaps:	126/596 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 SSTGPRILQAAEALMEGNVDSISLPAAAPLTAATTSSAKSLENSQGSDTPHSHANTTNADITMGI 205
            |:|........:.||...:.::.:..|..|:..||...:::.|.:
  Fly     2 STTSSESFVRGQRLMLIFLVAMCIVVACVLSTETTMPTQNMSNKE-------------------- 46

  Fly   206 ADHNPGGIQFERRAHVKQMMEHAWHNYKLYAWGKNELRPLS----------QRPHSASIFGSYDL 260
                    :.|.|...:.|..||::.|...|:..:||.|||          .|.....|.|::.:
  Fly    47 --------RAELREEARDMFYHAYNAYMQNAYPADELMPLSCKGRYRGVTPSRGDMDDILGNFSM 103

  Fly   261 GATIVDGLDTLYIMGLEKEYREGRDWIERKFSLDNISAELSVFETNIRFVGGML----------- 314
              |:||.||||.::|...|:......:.|....|: ...:||||||||.|||:|
  Fly   104 --TLVDTLDTLVLLGDFTEFDHAVKLVIRDVQFDS-DIIVSVFETNIRMVGGLLSAHILAEYLQK 165

  Fly   315 ---TLYAFTGDPLYKEKAQHVADKLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSEFGT 376
               |::.:.|:.|  |.::.:..:|||||.|.||||:|.||.:.|: |:........:..:..||
  Fly   166 HADTMHWYKGELL--EMSRELGYRLLPAFNTSTGIPHARVNLRLGM-KDPMLKKSRETCTACAGT 227

  Fly   377 LHLEFAYLSDITGNPLYRERVQTIRQVLKEI-EKPKGLYPNFLNPKTGKWGQLHMSLGALGDSYY 440
            :.||||.||.:||:|::..|.......|.:: .:...|....||..:|.|.:....:||..||||
  Fly   228 ILLEFAALSRLTGDPIFEVRAHAAMDALWKLRHRGSDLMGTVLNVHSGDWVRRDSGVGAGIDSYY 292

  Fly   441 EYLLKAWLQSGQTDEEAREMFDEAMLAILDKMVRTSPGGLTYVSD--LKFDRLEHK--------M 495
            |||.|:::..|  |::....|:....|:           :.|||:  :..|.|.|:        |
  Fly   293 EYLFKSYVLLG--DDKYLARFNRHYNAV-----------MKYVSEGPMLLDVLMHRPHAKSKNFM 344

  Fly   496 DHLACFSGGLFALGA----ATRQNDYTDKYMEVGKGITNTCHESYIRAPTQLGPEAFRFSEAVEA 556
            |.|..|..||..|..    |.:.::...:.|::         .::|       ||||    .|:.
  Fly   345 DSLLAFWPGLQVLSGDLKPAVQTHEMLYQVMQM---------HTFI-------PEAF----TVDF 389

  Fly   557 RALRSQEKYYILRPETFESYFVLWRLTHDQKYRDWGWEAVLALEKHCRTAHGYCGLRNVYQQEPQ 621
            :....|   :.||||..||.:.|:|.|.|..|...|.:|:..|::|.:.:.||..:.:|  :..:
  Fly   390 QIHWGQ---HPLRPEFIESTYFLYRATGDHHYLQVGKKALKTLQQHAKVSCGYAAVNDV--RTGK 449

  Fly   622 KDDVQQSFFLAETLKYLYLLFSD--DSVLPLDEWVFNTEAHPLPIK-----GANAYYRQAPV--- 676
            .:|...||.|:||:|||:|||||  |.::.:||:||.||||.||:.     .|...:||...
  Fly   450 HEDRMDSFVLSETIKYLFLLFSDPQDLIINVDEFVFTTEAHLLPLSIAQLGNATFSFRQTDEHNV 514

  Fly   677 -----TLPVSN 682
                 |.|.||
  Fly   515 LDFMRTCPSSN 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ia	NP_727408.2	Glyco_hydro_47	224..664	CDD:279825	151/480 (31%)
Edem2	NP_609611.1	Glyco_hydro_47	57..494	CDD:279825	151/480 (31%)
Edem2	NP_609611.1	PA_EDEM3_like	645..770	CDD:239041
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453087
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840