DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ia and man1a2

DIOPT Version :9

Sequence 1:	NP_727408.2	Gene:	alpha-Man-Ia / 31957	FlyBaseID:	FBgn0259170	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001243551.1	Gene:	man1a2 / 335538	ZFINID:	ZDB-GENE-070912-390	Length:	645	Species:	Danio rerio

Alignment Length:	540	Identity:	281/540 - (52%)
Similarity:	384/540 - (71%)	Gaps:	18/540 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 RILQAAEALMEGNVDSISLPAAAPLTAATTSSAKSLENSQGSDTPHSHANTTNADITMGIADHNP 210
            |.||.|:..:..:.:.:.       ....|:.||..|:.:..|.|..........: :|:.|.:|
Zfish   120 RALQEAKEKLRKSKEELK-------AEIQTAKAKVSEDLKKKDGPKPLPPVPMPKL-VGVNDGDP 176

  Fly   211 GGIQF-ERRAHVKQMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYDLGATIVDGLDTLYIM 274
            |.... |:|..:::||:|||.:|:.|.||.|||:||:::.||.:|||:..:||||||.|||||||
Zfish   177 GDPDTKEKRDKIREMMKHAWDSYRQYGWGHNELKPLAKKGHSTNIFGNSQMGATIVDALDTLYIM 241

  Fly   275 GLEKEYREGRDWIERKFSLD-NISAELSVFETNIRFVGGMLTLYAFTGDPLYKEKAQHVADKLLP 338
            ||..|:::|::|||:  :|| :::||:||||.||||:||:|..|..:|..::|.||..:|:||||
Zfish   242 GLHDEFKDGQEWIEQ--NLDFSVNAEVSVFEVNIRFIGGLLAAYYLSGQEVFKLKAVQLAEKLLP 304

  Fly   339 AFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSEFGTLHLEFAYLSDITGNPLYRERVQTIRQV 403
            ||.||||||:|:||.|:||.:|:||||||||||:||||||:||.:|:.:||||.|.::|..||::
Zfish   305 AFNTPTGIPWAMVNLKSGVGRNWGWASGGSSILAEFGTLHMEFVHLTYLTGNPAYYQKVMHIRKL 369

  Fly   404 LKEIEKPKGLYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKAWLQSGQTDEEAREMFDEAMLAI 468
            |.::::|.|||||:|||:||:|||.|.|:|.||||:|||||||||.|.:||.|||:.:|:|:.||
Zfish   370 LAKMDRPNGLYPNYLNPRTGRWGQHHTSVGGLGDSFYEYLLKAWLMSDKTDAEARKTYDDAIEAI 434

  Fly   469 LDKMVRTSPGGLTYVSDLKFDRLEHKMDHLACFSGGLFALGAATRQNDYTDKYMEVGKGITNTCH 533
            ...::|.|.||||::.:.|...||.||.||.||:||:|||||....:|....|:::|..|.:|||
Zfish   435 ERHLIRKSNGGLTFIGEWKNGHLERKMGHLTCFAGGMFALGADGSPDDKAGHYLQLGAEIAHTCH 499

  Fly   534 ESYIRAPTQLGPEAFRFSEAVEARALRSQEKYYILRPETFESYFVLWRLTHDQKYRDWGWEAVLA 598
            |||.|...:||||||:|...:||.|:|..|||||||||..|:|:.:||.|||.|||.|||||..|
Zfish   500 ESYDRTVLKLGPEAFKFDSGLEAVAVRQNEKYYILRPEVIETYWYMWRFTHDPKYRQWGWEAAQA 564

  Fly   599 LEKHCRTAHGYCGLRNVYQQEPQKDDVQQSFFLAETLKYLYLLFSDDSVLPLDEWVFNTEAHPLP 663
            ::||||.:.|:.|:::||...|..|||||||||||||||||||||.|.:|||:.|||||||||||
Zfish   565 IDKHCRVSGGFSGVKDVYSSNPTYDDVQQSFFLAETLKYLYLLFSSDELLPLENWVFNTEAHPLP 629

  Fly   664 IKGANAYYRQAPVTLPVSNA 683
            :      .....:|||.|.:
Zfish   630 V------LHLGNITLPGSES 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ia	NP_727408.2	Glyco_hydro_47	224..664	CDD:279825	260/440 (59%)
man1a2	NP_001243551.1	Glyco_hydro_47	191..630	CDD:279825	260/440 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583849
Domainoid	1	1.000	573	1.000	Domainoid score	I212
eggNOG	1	0.900	-	-		E1_KOG2204
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55982
Inparanoid	1	1.050	601	1.000	Inparanoid score	I917
OMA	1	1.010	-	-		QHG54359
OrthoDB	1	1.010	-	-		D263455at33208
OrthoFinder	1	1.000	-	-		FOG0001280
OrthoInspector	1	1.000	-	-		otm26462
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	1	1.100	-	-	LDO	PTHR11742
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R728
SonicParanoid	1	1.000	-	-		X635
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800