DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ia and Man1a1

DIOPT Version :9

Sequence 1:	NP_727408.2	Gene:	alpha-Man-Ia / 31957	FlyBaseID:	FBgn0259170	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	XP_006256559.1	Gene:	Man1a1 / 294410	RGDID:	1310891	Length:	746	Species:	Rattus norvegicus

Alignment Length:	463	Identity:	268/463 - (57%)
Similarity:	351/463 - (75%)	Gaps:	3/463 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 MGIADHNPGGIQF-ERRAHVKQMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYDLGATIVD 266
            :|:.:..|..... |:|:.:|:||.|||:|||.||||.|||:|:|:..||:|:||:.. ||||||
  Rat   273 IGVENREPADATIREKRSKIKEMMAHAWNNYKRYAWGLNELKPISKEGHSSSLFGNIK-GATIVD 336

  Fly   267 GLDTLYIMGLEKEYREGRDWIERKFSLDNISAELSVFETNIRFVGGMLTLYAFTGDPLYKEKAQH 331
            .||||:|||::.|::|.:.|| :|:...|::||:||||.|||||||:|:.|..:|:.::::||..
  Rat   337 ALDTLFIMGMKTEFQEAKSWI-KKYLDFNVNAEVSVFEVNIRFVGGLLSAYYLSGEEIFRKKAVE 400

  Fly   332 VADKLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSEFGTLHLEFAYLSDITGNPLYRER 396
            :..||||||.:|:|||:||:|.|:|:.:|:.|||||||||:|||||||||.:|:.::|||::.|:
  Rat   401 LGVKLLPAFHSPSGIPWALLNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHLAHLSGNPVFAEK 465

  Fly   397 VQTIRQVLKEIEKPKGLYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKAWLQSGQTDEEAREMF 461
            |..||.||.:::||:|||||:|||.:|:|||.|:|:|.||||:|||||||||.|.:||.||::|:
  Rat   466 VMNIRTVLNKLDKPEGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDLEAKKMY 530

  Fly   462 DEAMLAILDKMVRTSPGGLTYVSDLKFDRLEHKMDHLACFSGGLFALGAATRQNDYTDKYMEVGK 526
            .:|:.||...::|.|.|||||:::.|...|||||.||.||:||:|||||..........|:|:|.
  Rat   531 FDAVQAIETHLIRKSSGGLTYIAEWKGGLLEHKMGHLTCFAGGMFALGADGAPEARAQHYLELGA 595

  Fly   527 GITNTCHESYIRAPTQLGPEAFRFSEAVEARALRSQEKYYILRPETFESYFVLWRLTHDQKYRDW 591
            .|..||||||.|...:||||||||...|||.|.|..|||||||||..|:|..:||||||.|||.|
  Rat   596 EIARTCHESYNRTYVKLGPEAFRFDGGVEAIATRQNEKYYILRPEVIETYMYMWRLTHDPKYRTW 660

  Fly   592 GWEAVLALEKHCRTAHGYCGLRNVYQQEPQKDDVQQSFFLAETLKYLYLLFSDDSVLPLDEWVFN 656
            .||||.|||.|||...||.|||:||......||||||||||||||||||:||||.:|||:.|:||
  Rat   661 AWEAVEALESHCRVNGGYSGLRDVYIAHESYDDVQQSFFLAETLKYLYLIFSDDDLLPLEHWIFN 725

  Fly   657 TEAHPLPI 664
            |||||.||
  Rat   726 TEAHPFPI 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ia	NP_727408.2	Glyco_hydro_47	224..664	CDD:279825	261/439 (59%)
Man1a1	XP_006256559.1	Glyco_hydro_47	295..733	CDD:279825	261/439 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343601
Domainoid	1	1.000	565	1.000	Domainoid score	I222
eggNOG	1	0.900	-	-		E1_KOG2204
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	593	1.000	Inparanoid score	I937
OMA	1	1.010	-	-		QHG54359
OrthoDB	1	1.010	-	-		D263455at33208
OrthoFinder	1	1.000	-	-		FOG0001280
OrthoInspector	1	1.000	-	-		otm45570
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	1	1.100	-	-	O	PTHR11742
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X635
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770