DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ia and mns1

DIOPT Version :9

Sequence 1:	NP_727408.2	Gene:	alpha-Man-Ia / 31957	FlyBaseID:	FBgn0259170	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_594139.2	Gene:	mns1 / 2541719	PomBaseID:	SPAC2E1P5.01c	Length:	521	Species:	Schizosaccharomyces pombe

Alignment Length:	480	Identity:	170/480 - (35%)
Similarity:	261/480 - (54%)	Gaps:	48/480 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 RRAHVKQMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYDLGATIVDGLDTLYIMGLEKEYR 281
            |:|.:|:....:|.:|:.|.|||:|..|:.:|..:....|   :|..|:|.|||:.||||:::..
pombe    46 RKALIKKTFIESWTDYETYGWGKDEYYPIIKRGRNYLRKG---MGWMIIDSLDTMMIMGLDEQVL 107

  Fly   282 EGRDWIERKFSLDNISAELSVFETNIRFVGGMLTLYAFTGDPLYKEKAQHVADKLLPAFQTPTGI 346
            ..|:|:....:.:....|:|||||.||.:||:|:.|..:.|.||.::|..:||:||.|:.|.||:
pombe   108 RAREWVNNSLTWNQDDEEVSVFETTIRILGGLLSSYHLSQDKLYLDRAVDLADRLLAAYNTSTGL 172

  Fly   347 PYALVNTKTGVA----KNYGWASGGSSILSEFGTLHLEFAYLSDITGNPLYRERVQTIRQVL--K 405
            |.:.||..|..:    :.|..::      :|.||:.:|..|||.:||:|.|........:||  .
pombe   173 PRSNVNLGTRKSRKRTREYFVST------AESGTVQMELRYLSYLTGDPKYWITADKTMEVLLGD 231

  Fly   406 EIEKPKGLYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKAWLQSGQTDEEAREMFDEAMLAILD 470
            ......||.|..:|..||.:...::.||:.||||||||||..||...:....|:.||.::..|::
pombe   232 ATWSHTGLVPITVNLITGAYVGRNIRLGSHGDSYYEYLLKQDLQLFSSGTVYRKAFDLSVDGIIE 296

  Fly   471 KMVR-TSPGGLTYVSDLKFDRLEH----KMDHLACFSGGLFALGA---------------ATRQN 515
            .::. |:|....|:::|. ..|||    |||||.||..|....||               .|||
pombe   297 YLLNYTTPNHFAYIAELP-GGLEHAQLPKMDHLVCFLPGTLMWGATNGTSLEAARTSKNWGTRQ- 359

  Fly   516 DYTDKYMEVGKGITNTCHESYIRAPTQLGPEAFRFSEAVEARALRS--QEKYYILRPETFESYFV 578
               ::.:::.:.:..||:|.|....|.|.||...|........:.|  ::::.::||||.||.|:
pombe   360 ---ERDVKLAQELMRTCYEMYNMTATGLAPEIVFFDVDQTKNEIYSKRRDQHNLMRPETVESLFI 421

  Fly   579 LWRLTHDQKYRDWGWEAVLALEKHCRT--AHGYCGLRNVYQQEPQKD--DVQQSFFLAETLKYLY 639
            |:|:|.|:.||:|||...::..::.|.  ...:..|.:| :.:..||  |..:||:.||||||||
pombe   422 LYRITRDEIYREWGWNIFVSFLRYSRLPGRDAFTCLDSV-ESKKVKDQRDKTESFWFAETLKYLY 485

  Fly   640 LLFSDD-SVLPLDEWVFNTEAHPLP 663
            |||.|| |:|||..:.|||||||.|
pombe   486 LLFEDDFSILPLTNYTFNTEAHPFP 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ia	NP_727408.2	Glyco_hydro_47	224..664	CDD:279825	167/473 (35%)
mns1	NP_594139.2	Glyco_hydro_47	54..510	CDD:279825	166/470 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54359
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R728
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850