Protein Alignment alpha-Man-Ia and Edem1

DIOPT Version :10

• Sequence 1: NP_727408.2
• Gene: alpha-Man-Ia / 31957
• FlyBaseID: FBgn0259170
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_619618.1
• Gene: Edem1 / 192193
• MGIID: 2180139
• Length: 652
• Species: Mus musculus
• Alignment Length: 583
• Identity: 163/583 - (27%)
• Similarity: 248/583 - (42%)
• Gaps: 98/583 - (16%)

  Fly   127 SGPSSAPASSTLGSSSTGPRILQAAEALMEGNVDSISLPAAAPLTAATTSSAKSLENSQGSDTPH 191
            |||...|.         ||..|.......||.:::...|...|.......:........|...|.
Mouse    52 SGPVGPPG---------GPAWLHRPRRGTEGRLETPPEPGPTPGPGVCGPAHWGYALGGGGCGPD 107

  Fly   192 SHANTTNADITMGIADHNPGGIQFERRAHVKQMMEHAWHNYKLYAWGKNELRPLSQR-------- 248
            .:....:...        |..::.:.|...:.|....:.||..:|:.::||.|:..|
Mouse   108 EYERRYSGAF--------PPQLRAQMRDLARGMFVFGYDNYMAHAFPQDELNPIYCRGRGPDRGD 164

  Fly   249 PHSASI---FGSYDLGATIVDGLDTLYIMGLEKEYREGRDWIERKFSLDNISAELSVFETNIRFV 310
            |.:.:|   .|:|.|  |:||.||||.|||...|:::....:....|.|..|. :.|||..||.:
Mouse   165 PSNLNINDVLGNYSL--TLVDALDTLAIMGNSSEFQKAVKLVINTVSFDKDST-VQVFEATIRVL 226

  Fly   311 GGML----------------TLYAFTGDPLYKEKAQHVADKLLPAFQ-TPTGIPYALVNTKTGV- 357
            |.:|                |:..:..:.||  .|..:|.:|||||: |.|||||..||.||||
Mouse   227 GSLLSAHRIITDSKQPFGDMTIEDYDNELLY--MAHDLAVRLLPAFENTKTGIPYPRVNLKTGVP 289

  Fly   358 --AKNYGWASGGSSILSEFGTLHLEFAYLSDITGNPLYRERVQTIRQVLKEIEKPKGLYPNFLNP 420
              :.|....:|..|:|.|||.|.   ..|.|.|...:.|..|:.:..:.   ....||..|.:|.
Mouse   290 PDSNNETCTAGAGSLLVEFGILS---RLLGDSTFEWVARRAVKALWNLR---SNDTGLLGNVVNI 348

  Fly   421 KTGKWGQLHMSLGALGDSYYEYLLKAWLQSGQTDEEAREMFDEAMLAILDKMVR---------TS 476
            :||.|......|||..||:||||||:::..|  ::|..|||:.|..:|...:.|         ..
Mouse   349 QTGHWVGKQSGLGAGLDSFYEYLLKSYILFG--EKEDLEMFNAAYQSIQSYLRRGREACNEGEGD 411

  Fly   477 PGGLTYVSDLKFDRLEHKMDHLACFSGGLFALGAATRQNDYTDKYMEVGKGITNTC-HESYIRAP 540
            |.....|:......:...:|.|..|..||..|               :|......| |..|....
Mouse   412 PPLYVNVNMFSGQLMNTWIDSLQAFFPGLQVL---------------IGDVEDAICLHAFYYAIW 461

  Fly   541 TQLGPEAFRFSEAVEARALRSQEKYYILRPETFESYFVLWRLTHDQKYRDWGWEAVLALEKHCRT 605
            .:.|....|::..::|    ....:|.||||..||.::|::.|.:..|...|.:.:.:|||:.:.
Mouse   462 KRYGALPERYNWQLQA----PDVLFYPLRPELVESTYLLYQATKNPFYLHVGMDILQSLEKYTKV 522

  Fly   606 AHGYCGLRNVYQQEPQKDDVQQSFFLAETLKYLYLLFSDDSVLPLDE----WVFNTEAHPLPI 664
            ..||..|.:|.  :..|:|..:||||:||.|||||||.:::  |:.:    ::|.||.|.:.:
Mouse   523 KCGYATLHHVI--DKSKEDRMESFFLSETCKYLYLLFDEEN--PVHKSGTRYMFTTEGHIISV 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ia	NP_727408.2	LanC_like	216..664	CDD:471159	149/492 (30%)
Edem1	NP_619618.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	50..86		10/42 (24%)
		Glyco_hydro_47	132..577	CDD:460241	147/480 (31%)