DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ia and Man1a2

DIOPT Version :9

Sequence 1:	NP_727408.2	Gene:	alpha-Man-Ia / 31957	FlyBaseID:	FBgn0259170	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_034893.1	Gene:	Man1a2 / 17156	MGIID:	104676	Length:	641	Species:	Mus musculus

Alignment Length:	464	Identity:	269/464 - (57%)
Similarity:	356/464 - (76%)	Gaps:	4/464 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 MGIADHNPGGIQF-ERRAHVKQMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYDLGATIVD 266
            :|::..:|..::. ::|..:|:||:|||.||:.|.||.|||||::::.||.:||||..:||||||
Mouse   165 VGVSGGDPEDMEIKKKRDKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSTNIFGSSQMGATIVD 229

  Fly   267 GLDTLYIMGLEKEYREGRDWIERKFSLD-NISAELSVFETNIRFVGGMLTLYAFTGDPLYKEKAQ 330
            .|||||||||..|:.:|:.|||.  :|| ::::|:||||.||||:||:|..|..:|:.::|.||.
Mouse   230 ALDTLYIMGLHDEFMDGQRWIEE--NLDFSVNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKTKAV 292

  Fly   331 HVADKLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSEFGTLHLEFAYLSDITGNPLYRE 395
            .:|:||||||.||||||:|:||.|:||.:|:||||.|||||:||||||:||.:||.:||:..|..
Mouse   293 QLAEKLLPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFVHLSYLTGDLTYYN 357

  Fly   396 RVQTIRQVLKEIEKPKGLYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKAWLQSGQTDEEAREM 460
            :|..||::|:::|:|.|||||:|||:||:|||.|.|:|.||||:|||||||||.|.:||.|||.|
Mouse   358 KVMHIRKLLQKMERPNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDHEARRM 422

  Fly   461 FDEAMLAILDKMVRTSPGGLTYVSDLKFDRLEHKMDHLACFSGGLFALGAATRQNDYTDKYMEVG 525
            :|:|:.||...:::.|.|||.::.:.|...||.||.|||||:||:|||||...:.|....|:|:|
Mouse   423 YDDAVEAIEKHLIKKSRGGLVFIGEWKNGHLERKMGHLACFAGGMFALGADGSRKDKAGHYLELG 487

  Fly   526 KGITNTCHESYIRAPTQLGPEAFRFSEAVEARALRSQEKYYILRPETFESYFVLWRLTHDQKYRD 590
            ..|..||||||.|...:||||:|:|..||||.|:|..|||||||||..|:|:.|||.|||.:||.
Mouse   488 AEIARTCHESYDRTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRYRQ 552

  Fly   591 WGWEAVLALEKHCRTAHGYCGLRNVYQQEPQKDDVQQSFFLAETLKYLYLLFSDDSVLPLDEWVF 655
            |||||.||:||.||.:.|:.|:::||...|..|||||||||||||||||||||.|.:||||.|||
Mouse   553 WGWEAALAIEKSCRVSGGFSGVKDVYAPTPVHDDVQQSFFLAETLKYLYLLFSGDDLLPLDHWVF 617

  Fly   656 NTEAHPLPI 664
            ||||||||:
Mouse   618 NTEAHPLPV 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ia	NP_727408.2	Glyco_hydro_47	224..664	CDD:279825	264/440 (60%)
Man1a2	NP_034893.1	Neuromodulin_N	<109..208	CDD:331332	18/42 (43%)
Man1a2	NP_034893.1	Glyco_hydro_47	187..626	CDD:307602	264/440 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839763
Domainoid	1	1.000	572	1.000	Domainoid score	I227
eggNOG	1	0.900	-	-		E1_KOG2204
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55982
Inparanoid	1	1.050	596	1.000	Inparanoid score	I958
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54359
OrthoDB	1	1.010	-	-		D263455at33208
OrthoFinder	1	1.000	-	-		FOG0001280
OrthoInspector	1	1.000	-	-		otm43507
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	1	1.100	-	-	LDO	PTHR11742
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R728
SonicParanoid	1	1.000	-	-		X635
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800