DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ia and Edem2

DIOPT Version :9

Sequence 1:	NP_727408.2	Gene:	alpha-Man-Ia / 31957	FlyBaseID:	FBgn0259170	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_663512.2	Gene:	Edem2 / 108687	MGIID:	1915540	Length:	577	Species:	Mus musculus

Alignment Length:	494	Identity:	161/494 - (32%)
Similarity:	230/494 - (46%)	Gaps:	98/494 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 RAHVKQMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYDLGATIVDGLDTLYIMGLEKEYRE 282
            |..||.|..||:.:|...|:..:|||||:...|..  :||:.|  |::|.||||.|:|...|::.
Mouse    36 RERVKAMFYHAYDSYLENAFPYDELRPLTCDGHDT--WGSFSL--TLIDALDTLLILGNTSEFQR 96

  Fly   283 GRDWIERKFSLDNISAELSVFETNIRFVGGMLTLYAFT-------------GDPLYKEKAQHVAD 334
            ..:.::.....| |....||||||||.|||:|:.:..:             ..||.: .|:..|.
Mouse    97 VVEVLQDNVDFD-IDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLR-MAEEAAR 159

  Fly   335 KLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSEFGTLHLEFAYLSDITGNPLYRERVQT 399
            |||||||||||:||..||...||  |.|  ....:..:..||..:|||.||.:||:|::.:..:.
Mouse   160 KLLPAFQTPTGMPYGTVNLLHGV--NPG--ETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARV 220

  Fly   400 IRQVLKEIEKPKGLYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKA--WLQSGQTDEEAREMFD 462
            ....|.|.....||..|.::..||||......:||..|||:|||:|.  .||    |::...||.
Mouse   221 ALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQ----DKKLMAMFL 281

  Fly   463 EAMLAILD-----------KMVRTSPGGLTYVSDLKFDRLEHKMDHLACFSGGLFALGAATRQND 516
            |...||.:           :|.:.:      ||...|..||.....|....|.:
Mouse   282 EYNKAIRNYTHFDDWYLWVQMYKGT------VSMPVFQSLEAYWPGLQSLIGDI----------- 329

  Fly   517 YTDKYMEVGKGITNTCHESYIRAPTQLG--PEAFRFSE--AVEARALRSQEKYYILRPETFESYF 577
              |..|..        ..:|.....|.|  ||.:...:  .||.|      :.|.||||..||..
Mouse   330 --DNAMRT--------FLNYYTVWKQFGGLPEFYNIPQGYTVEKR------EGYPLRPELIESAM 378

  Fly   578 VLWRLTHDQKYRDWGWEAVLALEKHCRTAHGYCGLRNVYQQEPQKDDVQQSFFLAETLKYLYLLF 642
            .|:|.|.|....:.|.:||.::||..:...|:..::::  ::.:.|:..:|||||||:|||||||
Mouse   379 YLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDL--RDHKLDNRMESFFLAETVKYLYLLF 441

  Fly   643 -----------SDDSVL-PLDE-------WVFNTEAHPL 662
                       :.|||: |..|       ::|||||||:
Mouse   442 HPNNFIHNNGSTFDSVMTPHGECILGAGGYIFNTEAHPI 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ia	NP_727408.2	Glyco_hydro_47	224..664	CDD:279825	158/488 (32%)
Edem2	NP_663512.2	Glyco_hydro_47	42..480	CDD:307602	157/486 (32%)
Edem2	NP_663512.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839755
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840