Protein Alignment Hk and AAD14

DIOPT Version :10

• Sequence 1: NP_001259401.1
• Gene: Hk / 31955
• FlyBaseID: FBgn0263220
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_014068.1
• Gene: AAD14 / 855385
• SGDID: S000005275
• Length: 376
• Species: Saccharomyces cerevisiae
• Alignment Length: 370
• Identity: 95/370 - (25%)
• Similarity: 155/370 - (41%)
• Gaps: 77/370 - (20%)

  Fly   199 PTPGLRYKNLGK-SGLRISNVGLG------TWPVFSPGVSDDQAEAILKLAIESGINLFDISEAH 256
            ||...|.:.|.| :|:|:|.:.||      .|..|...::.:||..:|....|:|.|..|.:.::
Yeast    12 PTELGRLRVLSKTAGIRVSPLILGGASIGDAWSGFMGSMNKEQAFELLDAFYEAGGNCIDTANSY 76

  Fly   257 ----SETEIGKILQRAGWK-----RTAYVITTKVYWSTKSEERGLSRK-----------HIIECV 301
                ||..||:      |.     |...||.||.....|..|.|..:.           |:  .|
Yeast    77 QNEESEIWIGE------WMASRKLRDQIVIATKFTGDYKKYEVGGGKSANYCGNHKRSLHV--SV 133

  Fly   302 RASLQRLQLQYIDIVIIHKADPMCPM-EVVRAMSYVIQQGWAMYWG---TARWSQVEIMEAYTNC 362
            |.||::||..:|||:.||..|.|..: ||:.::..::|||..:|.|   |..|    ::.|....
Yeast   134 RDSLRKLQTDWIDILYIHWWDYMSSIEEVMDSLHILVQQGKVLYLGVSDTPAW----VVSAANYY 194

  Fly   363 RQFNCITPI-VEQSEYHMFCREKCELYLPEMYNKIGVGLMAWGPLSMALSDTQNGDKLFLPKGSF 426
            ...:..||. |.|.::::..|:.....:| |....|:.|..|        |...|       |.|
Yeast   195 ATSHGKTPFSVYQGKWNVLNRDFERDIIP-MARHFGMALAPW--------DVMGG-------GRF 243

  Fly   427 KTKSFSWTEDEIN----RNAALSPQGSWGKDRIDEGRRHCDRLRDLAALAEKLGC-SPTQLSIAW 486
            ::|. :..|.:.|    |.....|:.:..:.:|.|.         |..:||:.|. |.|.::||:
Yeast   244 QSKK-AMEERKKNGEGLRTFVGGPEQTELEVKISEA---------LTKIAEEHGTESVTAIAIAY 298

  Fly   487 SLKHEPVQCLLLGATSAEQLHQSLQSLQLLPRLSSSVMLELERIL 531
            ..........|:|....|.|.|::::|.:  :|:...:..||.|:
Yeast   299 VRSKAKNVFPLIGGRKIEHLKQNIEALSI--KLTPEQIEYLESIV 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hk	NP_001259401.1	AKR_AKR6B1	203..535	CDD:381368	93/366 (25%)
AAD14	NP_014068.1	AKR_AKR9A3_9B1-4	20..338	CDD:381373	89/357 (25%)