Protein Alignment Hk and Akr1c21

DIOPT Version :10

• Sequence 1: NP_001259401.1
• Gene: Hk / 31955
• FlyBaseID: FBgn0263220
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_084177.2
• Gene: Akr1c21 / 77337
• MGIID: 1924587
• Length: 323
• Species: Mus musculus
• Alignment Length: 367
• Identity: 77/367 - (20%)
• Similarity: 135/367 - (36%)
• Gaps: 118/367 - (32%)

  Fly   218 VGLGT-WPVFSPGVSDDQAEAILKLAIESGINLFDISEAH-SETEIGKILQRA---GWKRTAYVI 277
            :|.|| .|:..|   ..:|:.:.|:||::|.:.||.:..: :|..:|:.::..   |..|...:.
Mouse    19 LGFGTALPLECP---KSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIF 80

  Fly   278 TTKVYWSTKSEERGLSRKHIIECVRA----SLQRLQLQYIDIVIIHKADPMCPMEVVRAMSYVIQ 338
            .|...|.|....         |.|||    |||:||..|:|:.:||....:.|.|    .::.:.
Mouse    81 YTSKVWCTSLHP---------ELVRASLERSLQKLQFDYVDLYLIHYPMALKPGE----ENFPVD 132

  Fly   339 QGWAMYWG----TARWSQVE----------IMEAYTNCRQFNCI--------TPIVEQSEYHM-- 379
            :...:.:.    .|.|..:|          |..:..|.||...|        .|:..|.|.|.
Mouse   133 EHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEMILNKPGLKYKPVCNQVECHPYL 197

  Fly   380 -------FCREKCELYLPEMYNKIGVGLMAWGPLSMALSDTQNGDKLFLPKGSFKTKSFSWTEDE 437
                   ||:.|            .:.|:|:|.|.     ||.
Mouse   198 NQMKLLDFCKSK------------DIVLVAYGVLG-----TQR---------------------- 223

  Fly   438 INRNAALSPQGSWGKDRIDEGRRHCDRLRD---LAALAEKLGCSPTQLSIAWSLKHEPVQCLLLG 499
                     .|.|    :|:   :...|.|   |.::|:|...:|..:::.:.|:...|  :|..
Mouse   224 ---------YGGW----VDQ---NSPVLLDEPVLGSMAKKYNRTPALIALRYQLQRGIV--VLNT 270

  Fly   500 ATSAEQLHQSLQSLQLLPRLSSSVMLELERILENKPVRPPMI 541
            :...|::.:::|..:.  :|||..|..|:.:..|....|..|
Mouse   271 SLKEERIKENMQVFEF--QLSSEDMKVLDGLNRNMRYIPAAI 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hk	NP_001259401.1	AKR_AKR6B1	203..535	CDD:381368	75/359 (21%)
Akr1c21	NP_084177.2	AKR_AKR1C1-35	6..308	CDD:381334	75/363 (21%)