Protein Alignment Hk and AKR1B10

DIOPT Version :10

• Sequence 1: NP_001259401.1
• Gene: Hk / 31955
• FlyBaseID: FBgn0263220
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_064695.3
• Gene: AKR1B10 / 57016
• HGNCID: 382
• Length: 316
• Species: Homo sapiens
• Alignment Length: 293
• Identity: 64/293 - (21%)
• Similarity: 106/293 - (36%)
• Gaps: 101/293 - (34%)

  Fly   218 VGLGTWPVFSP-GVSDDQAEAILKLAIESGINLFDISEAH-SETEIGKI----LQRAGWKRTAYV 276
            ||||||.  || |    :.:..:|:||::|....|.:..: :|.|:|:.    :|....||....
Human    16 VGLGTWK--SPLG----KVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLF 74

  Fly   277 ITTKVYWSTKSEERGLSRKHIIECVRASLQRLQLQYIDIVIIH------KADPMCP--------- 326
            |.:|: |.| ..||.|.||    ....:|:.|:|.|:|:.:||      ..|.:.|
Human    75 IVSKL-WPT-FFERPLVRK----AFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIG 133

  Fly   327 -----MEVVRAMSYVIQQGWAMYWGTARWSQVEI----------MEAYTNCRQFNCITPIVEQSE 376
                 ::...||..::.:|.....|.:.:|..:|          .:..||  |..| .|.:.|.:
Human   134 GKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTN--QVEC-HPYLTQEK 195

  Fly   377 YHMFCREKCELYLPEMYNKIGVGLMAWGPLSMALSDTQNGDKLFLPKGSFKTKSFSWTEDEINRN 441
            ...:|..|            |:.:.|:.||.
Human   196 LIQYCHSK------------GITVTAYSPLG---------------------------------- 214

  Fly   442 AALSPQGSWGKDRIDEGRRHCDRLRDLAALAEK 474
               ||...|.|.. |.......:::::||..:|
Human   215 ---SPDRPWAKPE-DPSLLEDPKIKEIAAKHKK 243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hk	NP_001259401.1	AKR_AKR6B1	203..535	CDD:381368	64/293 (22%)
AKR1B10	NP_064695.3	AKR_AKR1B1-19	10..316	CDD:381333	64/293 (22%)