DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hk and kcnab1b

DIOPT Version :9

Sequence 1:	NP_001259401.1	Gene:	Hk / 31955	FlyBaseID:	FBgn0263220	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	XP_009297065.2	Gene:	kcnab1b / 555922	ZFINID:	ZDB-GENE-070912-690	Length:	413	Species:	Danio rerio

Alignment Length:	407	Identity:	170/407 - (41%)
Similarity:	261/407 - (64%)	Gaps:	51/407 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 DESNPVTIYRCRAPIAS----LDCMEEFSRSISLGSNPALPLR--------HGST------PTPG 202
            :.|..:.:.|.:|.::|    ..|....:||.|     ||.|:        ||.:      .|..
Zfish    23 ERSPGLVLQRQQAGLSSQHHTTGCSHWTARSSS-----ALELQQLRLFMQIHGFSLKDPLGTTTK 82

  Fly   203 LRYKNLGKSGLRISNVGLGTWPVFSPGVSDDQAEAILKLAIESGINLFDISEAHS----ETEIGK 263
            :.|:||||||||:|.:|||||..|...:||:.||.::.:|.|:|:||||.:|.:|    |..:|.
Zfish    83 MAYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAEQLMTIAYENGVNLFDTAEVYSAGKAEIILGN 147

  Fly   264 ILQRAGWKRTAYVITTKVYWSTKSE-ERGLSRKHIIECVRASLQRLQLQYIDIVIIHKADPMCPM 327
            |:::..|:|::.|||||:||..|:| |||||||||||.::.|||||||.|:|:|..::.|...||
Zfish   148 IIKKKCWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLDYVDVVFANRPDSNTPM 212

  Fly   328 -EVVRAMSYVIQQGWAMYWGTARWSQVEIMEAYTNCRQFNCITPIVEQSEYHMFCREKCELYLPE 391
             |:||||::||..|.:|||||:|||.:||||||:..||||.|.|:.||:|||:|.|:|.|:.|||
Zfish   213 EEIVRAMTHVINHGMSMYWGTSRWSAMEIMEAYSVARQFNLIPPVCEQAEYHLFQRDKVEMQLPE 277

  Fly   392 MYNKIGVGLMAWGPLSMAL--SDTQNGDKLFLPKGS-FKTKSFSWTEDEINRNAALSPQGSWGKD 453
            :|:|||||:::|.||:..:  ...:||    :|:.| ...||:.|.:::|           .|:|
Zfish   278 LYHKIGVGVVSWSPLACGIITGKYENG----IPESSRASMKSYQWLKEKI-----------LGED 327

  Fly   454 RIDEGRRHCDRLRDLAALAEKLGCSPTQLSIAWSLKHEPVQCLLLGATSAEQLHQSLQSLQLLPR 518
                ||:...:|::|..:||:|.|:..||:|||.|::|.|..:|||.::..||.::|.::|:||:
Zfish   328 ----GRKQQAKLKELTHIAERLSCTLPQLAIAWCLRNEGVSSVLLGTSNPAQLTENLGAIQVLPK 388

  Fly   519 LSSSVMLELERILENKP 535
            :::.|..::::||.|:|
Zfish   389 ITAHVASDIDKILGNRP 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hk	NP_001259401.1	Kv_beta	205..531	CDD:213602	152/334 (46%)
Hk	NP_001259401.1	Aldo_ket_red	218..531	CDD:278668	142/321 (44%)
kcnab1b	XP_009297065.2	Kv_beta	85..401	CDD:213602	152/334 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	300	1.000	Domainoid score	I1392
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000530
OrthoInspector	1	1.000	-	-		otm25505
orthoMCL	1	0.900	-	-		OOG6_100387
Panther	1	1.100	-	-	O	PTHR43150
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X715
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.910