DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hk and kcnab1a

DIOPT Version :9

Sequence 1:	NP_001259401.1	Gene:	Hk / 31955	FlyBaseID:	FBgn0263220	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	XP_021323321.1	Gene:	kcnab1a / 541540	ZFINID:	ZDB-GENE-050327-79	Length:	423	Species:	Danio rerio

Alignment Length:	354	Identity:	159/354 - (44%)
Similarity:	234/354 - (66%)	Gaps:	36/354 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 GLRYKNLGKSGLRISNVGLGTWPVFSPGVSDDQAEAILKLAIESGINLFDISEAH----SETEIG 262
            |:.|:||||||||:|.:|||||..|...:|||.||.::.:|.|||:||||.:|.:    :|..:|
Zfish    87 GMPYRNLGKSGLRVSCLGLGTWVTFGGQISDDVAEQLMTIAYESGVNLFDTAEVYAAGKAEVILG 151

  Fly   263 KILQRAGWKRTAYVITTKVYWSTKSE-ERGLSRKHIIECVRASLQRLQLQYIDIVIIHKADPMCP 326
            .|:::.||:|::.|||||:||..|:| |||||||||||.::.||||:|::|:|:|..::.|...|
Zfish   152 NIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRMQMEYVDVVFANRPDSNTP 216

  Fly   327 M-EVVRAMSYVIQQGWAMYWGTARWSQVEIMEAYTNCRQFNCITPIVEQSEYHMFCREKCELYLP 390
            | |:||||:|||.||.:|||||:||:.:||||||:..||||.|.|:.||:|||:|.|||.|:.||
Zfish   217 MEEIVRAMTYVINQGMSMYWGTSRWTAMEIMEAYSVARQFNLIPPVCEQAEYHLFQREKVEVQLP 281

  Fly   391 EMYNKIGVGLMAWGPLSMAL--SDTQNGDKLFLPKGS-FKTKSFSWTEDEINRNAALSPQGSWGK 452
            |:|:|||||.|.|.||:..:  ...:||    :|..| ...||:.|.:::|..
Zfish   282 ELYHKIGVGAMTWSPLACGIITGKYENG----IPDSSRASMKSYQWLKEKIVS------------ 330

  Fly   453 DRIDEGRRHCDRLRDLAALAEKLGCSPTQLSIAWSLKHEPVQCLLLGATSAEQLHQSLQSLQ--- 514
               ::||:...:|::|..:||||||:..||::||.|::|.|..:|||.::||||.::|.::|
Zfish   331 ---EDGRKQQAKLKELGHIAEKLGCTLPQLAVAWCLRNEGVSSVLLGTSNAEQLTENLGAIQVSK 392

  Fly   515 -----LLPRLSSSVMLELERILENKPVRP 538
                 ::.|......:||...:|....:|
Zfish   393 SFCHVIVARDLEGKKIELSSFMEGNLSKP 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hk	NP_001259401.1	Kv_beta	205..531	CDD:213602	156/342 (46%)
Hk	NP_001259401.1	Aldo_ket_red	218..531	CDD:278668	146/329 (44%)
kcnab1a	XP_021323321.1	Kv_beta	90..390	CDD:213602	152/318 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	300	1.000	Domainoid score	I1392
eggNOG	1	0.900	-	-		E1_COG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56491
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000530
OrthoInspector	1	1.000	-	-		otm25505
orthoMCL	1	0.900	-	-		OOG6_100387
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X715
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.760