Protein Alignment Hk and Akr1c19

DIOPT Version :10

• Sequence 1: NP_001259401.1
• Gene: Hk / 31955
• FlyBaseID: FBgn0263220
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_001094046.1
• Gene: Akr1c19 / 307096
• RGDID: 1562954
• Length: 323
• Species: Rattus norvegicus
• Alignment Length: 356
• Identity: 76/356 - (21%)
• Similarity: 140/356 - (39%)
• Gaps: 99/356 - (27%)

  Fly   215 ISNVGLGTWPVFSP-GVSDDQAEAILKLAIESGINLFDISEAH-SETEIGKILQ---RAG-WKRT 273
            |..:|.||   :.| .|.:::....:.||:|:|....|.:..: :|..:|:.::   .|| .||.
  Rat    16 IPALGFGT---YKPEEVPENKPLEAIHLAVEAGFRHIDTAYVYQTENHVGQAIKSKIAAGIVKRE 77

  Fly   274 AYVITTKVYWSTKSEERGLSRKHIIECVRASLQRLQLQYIDIVIIHKADPMCPMEVVRAMSYVIQ 338
            ...||||::.:....|.      ::..:..||:.|||.|:|:.|||     .||:        ::
  Rat    78 DIFITTKLWCTFHRPEM------VLSSLEKSLKNLQLDYVDLYIIH-----YPMQ--------MK 123

  Fly   339 QGWAMY----WGTARWSQVEI---MEAYTNCR-----------QFN--CITPIVEQS--EYHMFC 381
            .|..|:    .|...:..|::   .||...|:           .||  .:..|:.:.  :|...|
  Rat   124 SGEDMFPEDENGKTLFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEKILNKPGLKYKPVC 188

  Fly   382 RE-KCELYLPEMYNKIGVGLMAWGPLSMALSDTQNGDKL---FLPKGSFKTKSFSWTEDEINRNA 442
            .: :|.|||.:               |..|:..::.|.:   :...||.:.|  .|.:..
  Rat   189 NQVECHLYLNQ---------------SKLLNYCKSRDIVLVAYCALGSQRPK--RWVDPS----- 231

  Fly   443 ALSPQGSWGKDRIDEGRRHCDRLRD--LAALAEKLGCSPTQLSIAWSLKHEPVQCLLLGATSAEQ 505
              ||.                .|.|  |..:|:|...|..|:::.:.|:...|  :|..:....:
  Rat   232 --SPV----------------LLNDPVLCDVAKKHQRSSAQIALRYQLQRGNV--VLAQSYKENE 276

  Fly   506 LHQSLQSLQL-LPRLSSSVMLELERILENKP 535
            :.:::|..:. ||.....::..|:|.|...|
  Rat   277 IKENIQVFEFELPSEDMKILDSLDRNLRYAP 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hk	NP_001259401.1	AKR_AKR6B1	203..535	CDD:381368	75/354 (21%)
Akr1c19	NP_001094046.1	AKR_AKR1C1-35	6..308	CDD:381334	76/356 (21%)