DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hk and Kcnab2

DIOPT Version :9

Sequence 1:	NP_001259401.1	Gene:	Hk / 31955	FlyBaseID:	FBgn0263220	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	XP_017448703.1	Gene:	Kcnab2 / 29738	RGDID:	61828	Length:	383	Species:	Rattus norvegicus

Alignment Length:	386	Identity:	178/386 - (46%)
Similarity:	251/386 - (65%)	Gaps:	54/386 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 GSNPALPLRHGSTPTPGL--------------RYKNLGKSGLRISNVGLGTWPVFSPGVSDDQAE 236
            ||...|.||  .|.:||:              .|:||||||||:|.:|||||..|...::|:.||
  Rat     8 GSPARLSLR--QTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAE 70

  Fly   237 AILKLAIESGINLFDISEAH----SETEIGKILQRAGWKRTAYVITTKVYWSTKSE-ERGLSRKH 296
            .::.||.::||||||.:|.:    :|..:|.|:::.||:|::.|||||::|..|:| ||||||||
  Rat    71 HLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKH 135

  Fly   297 IIECVRASLQRLQLQYIDIVIIHKADPMCPM-----------------EVVRAMSYVIQQGWAMY 344
            |||.::|||:||||:|:|:|..::.||..||                 |.||||::||.||.|||
  Rat   136 IIEGLKASLERLQLEYVDVVFANRPDPNTPMEAGDPFSSFKSRTFIIEETVRAMTHVINQGMAMY 200

  Fly   345 WGTARWSQVEIMEAYTNCRQFNCITPIVEQSEYHMFCREKCELYLPEMYNKIGVGLMAWGPLSMA 409
            |||:|||.:||||||:..||||.|.||.||:|||||.|||.|:.|||:::|||||.|.|.||:..
  Rat   201 WGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACG 265

  Fly   410 LSDTQNGDKLFLPKGSFKTKSFSWTEDEINRNAALSPQGSWGKDRIDEGRRHCDRLRDLAALAEK 474
            :...:. |....|......|.:.|.:|:|     ||          :||||...:|::|.|:||:
  Rat   266 IVSGKY-DSGIPPYSRASLKGYQWLKDKI-----LS----------EEGRRQQAKLKELQAIAER 314

  Fly   475 LGCSPTQLSIAWSLKHEPVQCLLLGATSAEQLHQSLQSLQLLPRLSSSVMLELERILENKP 535
            |||:..||:|||.|::|.|..:||||::||||.:::.::|:||:||||::.|::.||.|||
  Rat   315 LGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEIDSILGNKP 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hk	NP_001259401.1	Kv_beta	205..531	CDD:213602	165/347 (48%)
Hk	NP_001259401.1	Aldo_ket_red	218..531	CDD:278668	155/334 (46%)
Kcnab2	XP_017448703.1	Aldo_ket_red_shaker	38..363	CDD:381367	163/340 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	302	1.000	Domainoid score	I1351
eggNOG	1	0.900	-	-		E1_COG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000530
OrthoInspector	1	1.000	-	-		otm46090
orthoMCL	1	0.900	-	-		OOG6_100387
Panther	1	1.100	-	-	O	PTHR43150
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X715
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.770