Protein Alignment Hk and AKR7L

DIOPT Version :10

• Sequence 1: NP_001259401.1
• Gene: Hk / 31955
• FlyBaseID: FBgn0263220
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_001335350.1
• Gene: AKR7L / 246181
• HGNCID: 24056
• Length: 331
• Species: Homo sapiens
• Alignment Length: 331
• Identity: 82/331 - (24%)
• Similarity: 127/331 - (38%)
• Gaps: 74/331 - (22%)

  Fly   237 AILKLAIESGINLFD----ISEAHSETEIGKILQRAGWKRTAYVITTKVY-WSTKSEERGLSRKH 296
            |:.:..:|.|....|    .|:..|||.:|.:..|.|.......|.||.. |...|    |....
Human    30 AVTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVKIATKANPWIGNS----LKPDS 90

  Fly   297 IIECVRASLQRLQLQYIDIVIIHKADPMCPM-EVVRAMSYVIQQGWAMYWGTARWSQVEIMEAYT 360
            :...:..||:|||...:|:..:|..|...|: |.:||...:.|:|..:..|.:.::..|:.|..|
Human    91 VRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICT 155

  Fly   361 NCRQFNCITPIVEQSEYHMFCRE-KCELYLPEMYNKIGVGLMAWGPLSMAL------SDTQNGDK 418
            .|:....|.|.|.|..|....|: :.||:  ......|:...|:.||:..|      .:.::|.:
Human   156 LCKSNGWILPTVYQGMYSATTRQVETELF--PCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQ 218

  Fly   419 LFLPKGSFKTKSFSWTEDEINRNAALSPQGSWGKDRIDEGRRHCDRLRDLAALAEK-----LGCS 478
               |.|.|    |.....||.||       .:.|:...||          .||.||     .|.|
Human   219 ---PVGRF----FGTQWAEIYRN-------HFWKEHHFEG----------IALVEKALQAAYGAS 259

  Fly   479 P---TQLSIAWSLKHEPVQ-----CLLLGATSAEQLHQSLQSLQLLPRLSSSVMLELERILENKP 535
            .   |..::.|...|..:|     .::||.:|.|||.|:|.:                  .|..|
Human   260 APSMTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAA------------------AEEGP 306

  Fly   536 VRPPMI 541
            :.|.::
Human   307 LEPAVV 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hk	NP_001259401.1	AKR_AKR6B1	203..535	CDD:381368	80/323 (25%)
AKR7L	NP_001335350.1	AKR_AKR7A1-5	10..319	CDD:381301	82/331 (25%)