Protein Alignment Hk and Akr1c14

DIOPT Version :10

• Sequence 1: NP_001259401.1
• Gene: Hk / 31955
• FlyBaseID: FBgn0263220
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_612556.1
• Gene: Akr1c14 / 191574
• RGDID: 708361
• Length: 322
• Species: Rattus norvegicus
• Alignment Length: 392
• Identity: 79/392 - (20%)
• Similarity: 145/392 - (36%)
• Gaps: 124/392 - (31%)

  Fly   176 MEEFSRSISLGSNPALPLRHGSTPTPGLRYKNLGKSGLRISNVGLGTWPVFSPGVSDDQAEAILK 240
            |:..|..::|.....:|:                        :|.||  .....|:.|:.....|
  Rat     1 MDSISLRVALNDGNFIPV------------------------LGFGT--TVPEKVAKDEVIKATK 39

  Fly   241 LAIESGINLFDISEAHS-ETEIGKILQ---RAGWKRTAYVITTKVYWSTKSEERGLSRKHIIE-C 300
            :||::|...||.:..:. |.|:|:.::   ..|..:...:..|...|||      ..|..::. |
  Rat    40 IAIDNGFRHFDSAYLYEVEEEVGQAIRSKIEDGTVKREDIFYTSKLWST------FHRPELVRTC 98

  Fly   301 VRASLQRLQLQYIDIVIIHKADPMCPMEVVRAMSYVIQQGWAMY----WGTARWSQVEI---MEA 358
            :..:|:..||.|:|:.|||     .||        .:|.|...:    .|...:..|:|   .||
  Rat    99 LEKTLKSTQLDYVDLYIIH-----FPM--------ALQPGDIFFPRDEHGKLLFETVDICDTWEA 150

  Fly   359 YTNCR-----------QFNC--ITPIVEQS--EYHMFCRE-KCELYLPEMYNKIGVGLMAWGPLS 407
            ...|:           .|||  :..|:.:.  :|...|.: :|.|||.:               |
  Rat   151 MEKCKDAGLAKSIGVSNFNCRQLERILNKPGLKYKPVCNQVECHLYLNQ---------------S 200

  Fly   408 MALSDTQNGDKL---FLPKGSFKTKSFSWTEDEINRNAALSPQGSWGKDRIDEGRRHCDRLRD-- 467
            ..|...::.|.:   :...||.:.|  :|.:.:       ||.                 |.|
  Rat   201 KMLDYCKSKDIILVSYCTLGSSRDK--TWVDQK-------SPV-----------------LLDDP 239

  Fly   468 -LAALAEKLGCSPTQLSIAWSLKHEPVQCLLLGATSAEQLHQSLQSLQLLPRLSSSVMLELERIL 531
             |.|:|:|...:|..:::.:.|:...|.  |:.:.:|:::.:..|..:.  :|:|..|..|:.:.
  Rat   240 VLCAIAKKYKQTPALVALRYQLQRGVVP--LIRSFNAKRIKELTQVFEF--QLASEDMKALDGLN 300

  Fly   532 EN 533
            .|
  Rat   301 RN 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hk	NP_001259401.1	AKR_AKR6B1	203..535	CDD:381368	75/365 (21%)
Akr1c14	NP_612556.1	AKR_AKR1C1-35	7..308	CDD:381334	77/386 (20%)