Protein Alignment Hk and Akr1c3

DIOPT Version :10

• Sequence 1: NP_001259401.1
• Gene: Hk / 31955
• FlyBaseID: FBgn0263220
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_612519.1
• Gene: Akr1c3 / 171516
• RGDID: 708428
• Length: 323
• Species: Rattus norvegicus
• Alignment Length: 362
• Identity: 78/362 - (21%)
• Similarity: 130/362 - (35%)
• Gaps: 116/362 - (32%)

  Fly   212 GLRISNVGLGTWPVFSPGVSDDQAEAILKLAIESGINLFDISEAH-SETEIGKI----LQRAGWK 271
            |..|..:|.||:.. ...:.....|: .|:||:.|....|.|..: :|.|||:.    ::....|
  Rat    13 GHSIPVLGFGTYAT-EENLRKKSMES-TKIAIDVGFRHIDCSHLYQNEEEIGQAIVSKIEDGTVK 75

  Fly   272 RTAYVITTKVYWSTKSEERGLSRKHIIECVRASLQ----RLQLQYIDIVIIH------KADPMCP 326
            |.....|:|: |||         .|..|.||.||:    :|.|.|:|:.:||      ..|.:.|
  Rat    76 REDIFYTSKL-WST---------SHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGDELLP 130

  Fly   327 M--------------EVVRAMSYVIQQGWAMYWGTARWSQVEIMEAYTNCRQFNCI--------T 369
            .              :...||......|.|...|.:.:          |.||...|        .
  Rat   131 QDEHGNLILDTVDLCDTWEAMEKCKDAGLAKSIGVSNF----------NRRQLEKILNKPGLKHR 185

  Fly   370 PIVEQSEYHMFCREKCELYLPEMYNKIGVGLMAWGPLSMALSDTQNGDKLFLPKGSFKTKSFSWT 434
            |:..|.|        |.|||.:               |..|:..:..|.:.:..|:..|:.:.:.
  Rat   186 PVCNQVE--------CHLYLNQ---------------SKLLAYCKMNDIVLVAYGALGTQRYKYC 227

  Fly   435 EDEINRNAALSPQGSWGKDRIDEGRRHCDRLRD---LAALAEKLGCSPTQLSIAWSLKHEPVQCL 496
               ||.:..:                    |.|   |..:|:|...:|..:::.:.|:...|  .
  Rat   228 ---INEDTPV--------------------LLDDPILCTMAKKYKRTPALIALRYQLERGIV--T 267

  Fly   497 LLGATSAEQLHQSLQSLQLLPRLSSSVMLELERILEN 533
            |:.:.:.|::.::||....  :|:|..|    .||:|
  Rat   268 LVKSFNEERIRENLQVFDF--QLASDDM----EILDN 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hk	NP_001259401.1	AKR_AKR6B1	203..535	CDD:381368	78/362 (22%)
Akr1c3	NP_612519.1	AKR_AKR1C1-35	6..308	CDD:381334	78/362 (22%)