Protein Alignment Hk and Hk

DIOPT Version :10

• Sequence 1: NP_001259401.1
• Gene: Hk / 31955
• FlyBaseID: FBgn0263220
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: XP_061515315.1
• Gene: Hk / 1279500
• VectorBaseID: AGAMI1_004544
• Length: 710
• Species: Anopheles gambiae
• Alignment Length: 608
• Identity: 343/608 - (56%)
• Similarity: 405/608 - (66%)
• Gaps: 90/608 - (14%)

  Fly     8 LNGDGSAAQSTSQSQSQSPAATAAAAPLLPHSHSHTLQPESTPLLLGHEQSGSAAPEGSGGGDVT 72
            |..:..||...:.:.:..|..|.:..||...|...|.: ::.|...  |.|.|..|     |...
Mosquito   125 LGSERQAAALATGTTATVPVGTTSPPPLSTGSGDRTFR-QAEPFYA--EGSISTTP-----GRTP 181

  Fly    73 DGAVTSIEMPTVVADDAGVPPLPLPLPQSTP-----QPLLMALPANLNFITGPTTQQLMIGNGAM 132
            ...:...:.|.::   |||   ..||.:.|.     ..|:..|..:...:|....:|    ..|.
Mosquito   182 PNTIAEEKSPVLL---AGV---KTPLLEDTSFGGTNTTLMETLQTSAAAVTPKEEEQ----RSAA 236

  Fly   133 GV-------------IPSTNDSNNNNNNNNNVDNTSDESNPVTIY-----------RCRAPIASL 173
            ||             :|.|  |:..:......|:|  ||...|||           .||||||||
Mosquito   237 GVLAAALQKVPQEKGLPET--SHLQDFPKGRQDST--ESEISTIYSQSQSDACHKMMCRAPIASL 297

  Fly   174 DCMEEFS---------RSISLGSNPALPLRHGSTPTPGLRYKNLGKSGLRISNVGLGTWPVFSPG 229
            |||||||         ||.|||||||:.:|..:|.|||||||||||||||:|||||||||:||||
Mosquito   298 DCMEEFSGTTAQLDFGRSTSLGSNPAIQIRSNATTTPGLRYKNLGKSGLRVSNVGLGTWPIFSPG 362

  Fly   230 VSDDQAEAILKLAIESGINLFDISEAHS----ETEIGKILQRAGWKRTAYVITTKVYWSTKSEER 290
            ||::||||||:||::|||||||:|||||    |.|:|||:|:||||||::|||||:|||||||||
Mosquito   363 VSEEQAEAILRLAVDSGINLFDLSEAHSGTRAEIELGKIIQKAGWKRTSFVITTKIYWSTKSEER 427

  Fly   291 GLSRKHIIECVRASLQRLQLQYIDIVIIHKADPMCPM-EVVRAMSYVIQQGWAMYWGTARWSQVE 354
            |||||||||.|:||||||||.|||::::||||.|||| |:||||:|||.|||:|||||||||.||
Mosquito   428 GLSRKHIIESVQASLQRLQLPYIDVILVHKADSMCPMEEIVRAMNYVISQGWSMYWGTARWSPVE 492

  Fly   355 IMEAYTNCRQFNCITPIVEQSEYHMFCREKCELYLPEMYNKIGVGLMAWGPLSMALSDTQNGDKL 419
            |||||||||||||:||||||||||||||||.||||||||||||||.||||||||.|.|.|||:||
Mosquito   493 IMEAYTNCRQFNCVTPIVEQSEYHMFCREKAELYLPEMYNKIGVGFMAWGPLSMYLGDAQNGEKL 557

  Fly   420 FLPKGSFKTK--SFSWTEDEINR----NAALSPQGS-------------------WGKDRIDEGR 459
            ::||||.|:|  |:||.|||:|:    .:|..|..|                   ..||..||.|
Mosquito   558 WIPKGSLKSKSQSYSWIEDEVNKEVSERSATRPHCSVHICVLFFLFLLHLAVMLHLRKDLQDEAR 622

  Fly   460 RHCDRLRDLAALAEKLGCSPTQLSIAWSLKHEPVQCLLLGATSAEQLHQSLQSLQLLPRLSSSVM 524
            |..|:.||::.|||||||:..||||||||||||||||||||||.||||||||:||||||||:.||
Mosquito   623 RLYDKARDISNLAEKLGCNAVQLSIAWSLKHEPVQCLLLGATSPEQLHQSLQALQLLPRLSTGVM 687

  Fly   525 LELERILENKPVRPPMISTLALR 547
            ||:||||||||||||.|||||||
Mosquito   688 LEIERILENKPVRPPPISTLALR 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hk	NP_001259401.1	AKR_AKR6B1	203..535	CDD:381368	262/361 (73%)
Hk	XP_061515315.1	None