Protein Alignment Hk and AKR1C4

DIOPT Version :10

• Sequence 1: NP_001259401.1
• Gene: Hk / 31955
• FlyBaseID: FBgn0263220
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_001809.4
• Gene: AKR1C4 / 1109
• HGNCID: 387
• Length: 323
• Species: Homo sapiens
• Alignment Length: 354
• Identity: 74/354 - (20%)
• Similarity: 135/354 - (38%)
• Gaps: 108/354 - (30%)

  Fly   218 VGLGTWPVFSPGVSDDQAEAILKLAIESGINLFDISEAH-SETEIGKILQR----AGWKRTAYVI 277
            :|.||:.  .|.|..::|..:.|||||:|....|.:..: :|.::|..::.    ...||.....
Human    19 LGFGTYA--PPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKIADGSVKREDIFY 81

  Fly   278 TTKVYWSTKSEERGLSRKHIIECVRASLQRLQLQYIDIVIIHKADPMCPMEVVRAMSYVIQQGWA 342
            |:|: |.|..:.     :.:...:.:||::|||.|:|:.::|....:.|.|......   :.|..
Human    82 TSKL-WCTFFQP-----QMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKD---ENGKV 137

  Fly   343 MYWG---TARWSQVEIME-------------AYTNCRQFNCI--------TPIVEQSEYHM---- 379
            ::..   :|.|   |:||             :..||||...|        .|:..|.|.|.
Human   138 IFDTVDLSATW---EVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECHPYLNQ 199

  Fly   380 -----FCREKCELYLPEMYNKIGVGLMAWGPLSMALSDTQNGDKLFLPKGSFKTKSFSWTEDEIN 439
                 ||:.|            .:.|:|...|.     ||. .||::...|...     .||.:
Human   200 SKLLDFCKSK------------DIVLVAHSALG-----TQR-HKLWVDPNSPVL-----LEDPV- 240

  Fly   440 RNAALSPQGSWGKDRIDEGRRHCDRLRDLAALAEKLGCSPTQLSIAWSLKHEPVQCLLLGATSAE 504
                                        |.|||:|...:|..:::.:.|:...|  :|..:.:.:
Human   241 ----------------------------LCALAKKHKQTPALIALRYQLQRGVV--VLAKSYNEQ 275

  Fly   505 QLHQSLQSLQLLPRLSSSVMLELERILEN 533
            ::.:::|..:.  :|:|..|..|:.:..|
Human   276 RIRENIQVFEF--QLTSEDMKVLDGLNRN 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hk	NP_001259401.1	AKR_AKR6B1	203..535	CDD:381368	74/354 (21%)
AKR1C4	NP_001809.4	AKR_AKR1C1-35	6..306	CDD:381334	74/354 (21%)