Protein Alignment Hk and Akr1c18

DIOPT Version :10

• Sequence 1: NP_001259401.1
• Gene: Hk / 31955
• FlyBaseID: FBgn0263220
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_598827.1
• Gene: Akr1c18 / 105349
• MGIID: 2145420
• Length: 323
• Species: Mus musculus
• Alignment Length: 361
• Identity: 76/361 - (21%)
• Similarity: 127/361 - (35%)
• Gaps: 110/361 - (30%)

  Fly   212 GLRISNVGLGTWPVFSPGVSDDQAEAILKLAIESGINLFDISEAH-SETEIGK-ILQRA--GWKR 272
            |..|..:|.||:.. ...:.....|: .|:||:.|....|.|..: :|.|||: ||.:.  |..:
Mouse    13 GHSIPVLGFGTYAT-EEHLKKKSMES-TKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVK 75

  Fly   273 TAYVITTKVYWSTKSEERGLSRKHIIECVRASLQ----RLQLQYIDIVIIHKADPMCP------- 326
            ...:..|...|||         .|..|.||.||:    :|.|.|:|:.:||....:.|
Mouse    76 REDIFYTSKLWST---------SHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLPK 131

  Fly   327 -------------MEVVRAMSYVIQQGWAMYWGTARWSQVEIMEAYTNCRQFNCI--------TP 370
                         .:...||......|.|...|.:.:          |.||...|        .|
Mouse   132 DEHGNLIFDTVDLCDTWEAMEKCKDAGLAKSIGVSNF----------NRRQLEMILNKPGLKYKP 186

  Fly   371 IVEQSEYHMFCREKCELYLPEMYNKIGVGLMAWGPLSMALSDTQNGDKLFLPKGSFKTKSFSWTE 435
            :..|.|        |.|||.:               |..|:..:..|.:.:..|:..|:.:.:.
Mouse   187 VCNQVE--------CHLYLNQ---------------SKLLAYCKMNDIVLVAYGALGTQRYKYC- 227

  Fly   436 DEINRNAALSPQGSWGKDRIDEGRRHCDRLRD---LAALAEKLGCSPTQLSIAWSLKHEPVQCLL 497
              ||.:..:                    |.|   |.|:|:|...:|..:::.:.|....|  .|
Mouse   228 --INEDTPV--------------------LLDDPVLCAMAKKYKRTPALIALRYQLDRGIV--AL 268

  Fly   498 LGATSAEQLHQSLQSLQLLPRLSSSVMLELERILEN 533
            ..:.:.|::.:::|....  :|:|..|..|:.:..|
Mouse   269 AKSFNEERIRENMQVFDF--QLASDDMKILDGLDRN 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hk	NP_001259401.1	AKR_AKR6B1	203..535	CDD:381368	76/361 (21%)
Akr1c18	NP_598827.1	AKR_AKR1C1-35	6..308	CDD:381334	76/361 (21%)