Protein Alignment Hk and AKR1A1

DIOPT Version :10

• Sequence 1: NP_001259401.1
• Gene: Hk / 31955
• FlyBaseID: FBgn0263220
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_006057.1
• Gene: AKR1A1 / 10327
• HGNCID: 380
• Length: 325
• Species: Homo sapiens
• Alignment Length: 365
• Identity: 75/365 - (20%)
• Similarity: 145/365 - (39%)
• Gaps: 103/365 - (28%)

  Fly   211 SGLRISNVGLGTWPVFSPGVSDDQAEAILKLAIESGINLFDISEAH-SETEIGKILQR-----AG 269
            :|.::..:|||||. ..||    |.:|.:|.|:..|....|.:..: :|.|||:.|:.     ..
Human    10 TGQKMPLIGLGTWK-SEPG----QVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKA 69

  Fly   270 WKRTAYVITTKVYWSTKSEERGLSRKHIIECVRASLQRLQLQYIDIVIIH------KADPMCP-- 326
            ..|....:|:|: |:||...     :.:...:|.:|..|||:|:|:.::|      :.|...|
Human    70 VPREELFVTSKL-WNTKHHP-----EDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKN 128

  Fly   327 ------------MEVVRAMSYVIQQGWAMYWGTARWS--QVEIMEAYTNCR----QFNCITPIVE 373
                        .|..:|:..::.:|.....|.:.::  |::.:.:..:.|    |..| .|.:.
Human   129 ADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVEC-HPYLA 192

  Fly   374 QSEYHMFCREKCELYLPEMYNKIGVGLMAWGPLSMALSDTQNGDKLFLPKGSFKTKSFSWTEDEI 438
            |:|....|:.:            |:.:.|:.||..:....::.|:..|            .|:.:
Human   193 QNELIAHCQAR------------GLEVTAYSPLGSSDRAWRDPDEPVL------------LEEPV 233

  Fly   439 NRNAALSPQGSWGKDRIDEGRRHCDRLRDLAALAEKLGCSPTQLSIAWSLKHEPVQCLLLGATSA 503
                                         :.|||||.|.||.|:.:.|.::.: |.|:....|.:
Human   234 -----------------------------VLALAEKYGRSPAQILLRWQVQRK-VICIPKSITPS 268

  Fly   504 EQLHQSLQSLQLLP-RLSSSVMLELERILENKPVRPPMIS 542
                :.||::::.. ..|...|.:|..:.:|.....||::
Human   269 ----RILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLT 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hk	NP_001259401.1	AKR_AKR6B1	203..535	CDD:381368	73/356 (21%)
AKR1A1	NP_006057.1	AKR_AKR1A1-4	8..312	CDD:381332	75/365 (21%)