DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoU and Rhobtb3

DIOPT Version :9

Sequence 1:	NP_001036266.1	Gene:	RhoU / 31945	FlyBaseID:	FBgn0083940	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_082769.1	Gene:	Rhobtb3 / 73296	MGIID:	1920546	Length:	611	Species:	Mus musculus

Alignment Length:	306	Identity:	56/306 - (18%)
Similarity:	94/306 - (30%)	Gaps:	115/306 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 VALGVGGGPFIFGIAPEQQVTDYGSNPLPPTPPQLKQQSVISRSPLQQSLSDTSAASSGKGSKFL 355
            ||||..|..|.....|...:..|                 :.||||          .||..|..|
Mouse     6 VALGNEGDTFHQDNRPSGLIRTY-----------------LGRSPL----------VSGDESSLL 43

  Fly   356 LRKRKSKKTTAAAAATTEAATTAKKDGKKAIAQPQPSIKCVLVGDGAVGKTNLILSYLENRFNPE 420
            |.           ||:|.|        :....:.|.|         |.|...|::
Mouse    44 LN-----------AASTVA--------RPVFTEYQAS---------AFGNVKLVV---------- 70

  Fly   421 HIPTASDIYNADVNVNESPVHLTICDTAGQDTLDPLRELCYPDSDVFLLCFSVVKPETFRAIKTK 485
            |.....||:::|...:.:.:                     ..:|:.::.::|....:|..:|..
Mouse    71 HDCPVWDIFDSDWYTSRNLI---------------------GGADIIVIKYNVNDKFSFHEVKDN 114

  Fly   486 WAP--KFAKTKAALIL--VGTQADLRTSPNVLNKLQTNGEEAISYADAWDLATTIGAKYIETSS- 545
            :.|  |.|.....:|:  |||:.: ...|.......::....::..:...||..:||.|:|..|
Mouse   115 YIPVIKRASNSVPVIIAAVGTRQN-EELPCTCPLCTSDRGSCVTTTEGIQLAKELGATYLELHSL 178

  Fly   546 -----------------------ATQDKVKDVFDTAIWEGLVPTTL 568
                                   .|.:|:|....|:.:.|:.|..|
Mouse   179 DDFYIGKYFGGVLEYFMIQALNQKTSEKMKKRKMTSSFHGIRPPQL 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoU	NP_001036266.1	Wrch_1	393..562	CDD:133330	30/196 (15%)
RhoU	NP_001036266.1	RHO	395..559	CDD:197554	30/191 (16%)
Rhobtb3	NP_082769.1	Rho-like	1..175		47/255 (18%)
		P-loop_NTPase	34..174	CDD:304359	36/209 (17%)
		BTB	413..515	CDD:279045
		Interaction with Rab9. /evidence=ECO:0000250	420..611
		BTB	421..518	CDD:197585
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900