DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoU and RHOH

DIOPT Version :9

Sequence 1:	NP_001036266.1	Gene:	RhoU / 31945	FlyBaseID:	FBgn0083940	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001265288.1	Gene:	RHOH / 399	HGNCID:	686	Length:	191	Species:	Homo sapiens

Alignment Length:	171	Identity:	55/171 - (32%)
Similarity:	88/171 - (51%)	Gaps:	10/171 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 SIKCVLVGDGAVGKTNLILSYLENRFNPEHIPTASDIYNADVNVNESPVHLTICDTAGQDTLDPL 456
            |||||||||.|||||:|::.:....|...:.||..:....||.::...:.|.:.||||.|....:
Human     4 SIKCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVDVFMDGIQISLGLWDTAGNDAFRSI 68

  Fly   457 RELCYPDSDVFLLCFSVVKPETFRAIKTKWAPKFAKTK--AALILVGTQADLRTSPNVLNKLQTN 519
            |.|.|..:||.|:|:||....:|..:|.||..:.....  ..:::|.||.|.|       ::..:
Human    69 RPLSYQQADVVLMCYSVANHNSFLNLKNKWIGEIRSNLPCTPVLVVATQTDQR-------EMGPH 126

  Fly   520 GEEAISYADAWDLATTIGAK-YIETSSATQDKVKDVFDTAI 559
            ....::..:...||..:.|| |:|.|:.:...|:.||:.|:
Human   127 RASCVNAMEGKKLAQDVRAKGYLECSALSNRGVQQVFECAV 167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoU	NP_001036266.1	Wrch_1	393..562	CDD:133330	54/170 (32%)
RhoU	NP_001036266.1	RHO	395..559	CDD:197554	51/166 (31%)
RHOH	NP_001265288.1	Rho	5..169	CDD:206641	54/170 (32%)
		Effector region. /evidence=ECO:0000250	33..41		2/7 (29%)
		Interaction with ZAP70. /evidence=ECO:0000250	73..86		6/12 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1091615at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820