Protein Alignment Naxe and EDC3

DIOPT Version :10

• Sequence 1: NP_572604.2
• Gene: Naxe / 31944
• FlyBaseID: FBgn0030178
• Length: 230
• Species: Drosophila melanogaster
• Sequence 2: NP_079359.2
• Gene: EDC3 / 80153
• HGNCID: 26114
• Length: 508
• Species: Homo sapiens
• Alignment Length: 246
• Identity: 50/246 - (20%)
• Similarity: 98/246 - (39%)
• Gaps: 66/246 - (26%)

  Fly     3 LKYLNQKEAIAVDQELFNDYKFSVDQLMELAGLSCAHAVA--------KCFPAEKH--PRILVCC 57
            :.|...|:.::|.::    :..::::.:|:.|: ||..:|        :..|...|  |.:.:.|
Human   282 ISYELHKKLLSVAEK----HGLTLERRLEMTGV-CASQMALTLLGGPNRLNPKNVHQRPTVALLC 341

  Fly    58 GPGNNGGDGLVAARHLALMGYTPTIYYPKPTAKPLFENLSHQ------CQQMDICDVKECPSVES 116
            ||...|..|:...||||  .:...:....|....:.|:::::      .|...:..:|:.|:
Human   342 GPHVKGAQGISCGRHLA--NHDVQVILFLPNFVKMLESITNELSLFSKTQGQQVSSLKDLPT--- 401

  Fly   117 AARDYDLILDALFGFSFKPPVRAD------------FVAVVELMQQTKLPIASVDIPSGWDVEKG 169
              ...||:::.|           |            :.|.|....|.:.|:.|:| |...:||:|
Human   402 --SPVDLVINCL-----------DCPENVFLRDQPWYKAAVAWANQNRAPVLSID-PPVHEVEQG 452

  Fly   170 KLTECDVEPALLISLTAPKLCARQFRGEHH---YLGGRFVPPALQRKYELN 217
                .|.:.:|.:.|..|       .|||.   ||....:|..:.::..:|
Human   453 ----IDAKWSLALGLPLP-------LGEHAGRIYLCDIGIPQQVFQEVGIN 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Naxe	NP_572604.2	PLN03049	3..>230	CDD:215550	50/246 (20%)
EDC3	NP_079359.2	Required for P-body targeting and interaction with DCP1A. /evidence=ECO:0000250	1..79
		LSm16_N	2..66	CDD:212484
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..192
		Edc3_linker	102..194	CDD:465188
		Required for interaction with DDX6. /evidence=ECO:0000250	191..296		3/13 (23%)
		FDF	198..301	CDD:430668	3/22 (14%)
		YjeF_N	302..455	CDD:427546	36/176 (20%)