DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2972 and NOB1

DIOPT Version :9

Sequence 1:	NP_001285072.1	Gene:	CG2972 / 31943	FlyBaseID:	FBgn0030177	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_014699.1	Gene:	NOB1 / 854221	SGDID:	S000005582	Length:	459	Species:	Saccharomyces cerevisiae

Alignment Length:	442	Identity:	129/442 - (29%)
Similarity:	198/442 - (44%)	Gaps:	100/442 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IKFLVADTTAFI--NAVPLNEYAEQVLTVPDVVAEVRNKRQIRRLCVLPF--DLQVREPRPESIK 68
            ::.|:.|.|..|  :......||:...|.|.|..|:::.:..:.|.:...  .|::..|...||.
Yeast     9 VRALILDATPLITQSYTHYQNYAQSFYTTPTVFQEIKDAQARKNLEIWQSLGTLKLVHPSENSIA 73

  Fly    69 HCVEFAKKTGDYASLSGIDLKVISLTYELEAD-NVGTDHLRQEPVMAQTIASKDKPEEMQDANNK 132
            ....|||.||||:.||..||.:::||||||.. |.|...||:            ||.:..|| :|
Yeast    74 KVSTFAKLTGDYSVLSANDLHILALTYELEIKLNNGDWRLRK------------KPGDALDA-SK 125

  Fly   133 RLVGWYMPEGEEEEEEDSEEEDDYSQEEDDAEGDEQEANESPDTVKAAIEAQLAGKEPFASETIE 197
            ..||   .:|:::..||       :::|:|:|...::.|:           :..||:..|..  |
Yeast   126 ADVG---TDGKQKLTED-------NKKEEDSESVPKKKNK-----------RRGGKKQKAKR--E 167

  Fly   198 KEEDQDQEPSQEELDKLFEQLKCAPSAEEEKELSELLVSQPAEVDEEVSEPQEAKQSQNLD---E 259
            ..|.::.|.:..||:.         .|||..|        .|...|::...:..|:|.:|:   |
Yeast   168 AREAREAENANLELES---------KAEEHVE--------EAGSKEQICNDENIKESSDLNEVFE 215

  Fly   260 DVGDDG-WITHSNIKKA-----------KKALEGKVETDEVP------PVACMTTDYALQNVLKQ 306
            |..||| |||..|:.:|           ...:|...|...|.      .||..|.|:|:|||..|
Yeast   216 DADDDGDWITPENLTEAIIKDSGEDTTGSLGVEASEEDRHVALNRPENQVALATGDFAVQNVALQ 280

  Fly   307 LNLHLA-ALNGRIIKQLRTYILRCYACYKTTSI----MTKVFCPNCGNK-TLKRVAVSLD-ENGR 364
            :||:|. .::|..||::|.|:|||:||:|...:    ..|.||.:||.: ||.|.|||:| ..|.
Yeast   281 MNLNLMNFMSGLKIKRIRNYMLRCHACFKIFPLPKDGKPKHFCASCGGQGTLLRCAVSVDSRTGN 345

  Fly   365 QVIHINT---------RRPLTNKYKNQSLPRF--QGGKHSR---NPILFEDQ 402
            ...|:.:         |..:.:.....|..|:  :|..||:   |.||.|||
Yeast   346 VTPHLKSNFQWNNRGNRYSVASPLSKNSQKRYGKKGHVHSKPQENVILREDQ 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2972	NP_001285072.1	PIN_Nob1	11..120	CDD:189046	36/113 (32%)
		PIN_SF	<279..355	CDD:301351	33/87 (38%)
		NOB1_Zn_bind	319..390	CDD:285925	27/87 (31%)
NOB1	NP_014699.1	PIN_6	12..102	CDD:407279	29/89 (33%)
NOB1	NP_014699.1	Nob1	102..346	CDD:224356	86/296 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345379
Domainoid	1	1.000	47	1.000	Domainoid score	I3046
eggNOG	1	0.900	-	-		E1_COG1439
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31924
Inparanoid	1	1.050	110	1.000	Inparanoid score	I1384
Isobase	1	0.950	-	0	Normalized mean entropy	S3224
OMA	1	1.010	-	-		QHG54261
OrthoFinder	1	1.000	-	-		FOG0005109
OrthoInspector	1	1.000	-	-		oto99771
orthoMCL	1	0.900	-	-		OOG6_101333
Panther	1	1.100	-	-	LDO	PTHR12814
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R821
SonicParanoid	1	1.000	-	-		X3629
TreeFam	1	0.960	-	-
	15	14.830