DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2972 and Nob1

DIOPT Version :9

Sequence 1:	NP_001285072.1	Gene:	CG2972 / 31943	FlyBaseID:	FBgn0030177	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_080553.1	Gene:	Nob1 / 67619	MGIID:	1914869	Length:	403	Species:	Mus musculus

Alignment Length:	463	Identity:	165/463 - (35%)
Similarity:	255/463 - (55%)	Gaps:	75/463 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IKFLVADTTAFINAVPLNEYAEQVLTVPDVVAEVRNKRQIRRLCVLPFDLQVREPRPESIKHCVE 72
            ::.:|||..||:...||.:..:.:.|:.:||.|:|:|...|||.|||:.|:.:||.||.::...|
Mouse     4 VEHVVADAGAFLRDAPLQDIGKNIYTIREVVREIRDKATRRRLAVLPYQLRFKEPLPEYVRLVTE 68

  Fly    73 FAKKTGDYASLSGIDLKVISLTYELEADNVGTDHLRQEPVMAQTIASKDKPEEMQDANNKRLVGW 137
            |:||||||.|||..|::|::|||:|||:.||..||::||..|:..:|...||     ....:.|:
Mouse    69 FSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKKEPEKAKVSSSIQHPE-----TALHISGF 128

  Fly   138 YMPEGEEEEEEDSEEEDDYSQEEDDAEGDEQEANESPDTVKAAIEAQLAGKEPFASETIEKEEDQ 202
            ::|...:..:|               ..|...|.:.|:.::            |:|....:
Mouse   129 HLPSKSKPLQE---------------AVDRGHAADGPENLE------------FSSFMFWR---- 162

  Fly   203 DQEPSQEELDKLFEQLKCAPSAEEEKELSELLVSQPAEVDEEVSEPQEAKQSQNLDEDVGDDGWI 267
                              .|....::||.|||:....|.:||       ::.::.|:|.|  |||
Mouse   163 ------------------TPLPNIDRELQELLIDGREEEEEE-------EECEDSDDDGG--GWI 200

  Fly   268 THSNIKKAKKALEGKVETDEVPPVACMTTDYALQNVLKQLNLHLAALNGRIIKQLRTYILRCYAC 332
            |.||||:.::.|| :.:|.|...|.|:|||:|:||||.|:.||:.|:||.::::.|:|||||:.|
Mouse   201 TPSNIKQIQQELE-QCDTPEDVQVGCVTTDFAMQNVLLQMGLHVLAVNGMLVREARSYILRCHGC 264

  Fly   333 YKTTSIMTKVFCPNCGNKTLKRVAVSLDENGRQVIHINTRRP--LTNKYKNQSLPRFQGGKHSRN 395
            :||||.|.:|||.:|||||||:|:|:::::|...:|. :|.|  |..:....|||..:|||::.|
Mouse   265 FKTTSDMNRVFCGHCGNKTLKKVSVTINDDGTLHMHF-SRNPKVLNPRGLRYSLPTPKGGKYAIN 328

  Fly   396 PILFEDQPMPRQMPSRVAKTKTNALDQDYTAGFSPFVLRDVDSKSAMLRSKGNLKEWARNNNFEE 460
            |.|.|||..|:...|:.|:.||:....||.||.|||...|:.|:||:|:        .|:.....
Mouse   329 PHLTEDQRFPQLRLSQKARQKTDVFAPDYIAGVSPFAENDISSRSAILQ--------VRDGMLGA 385

  Fly   461 DRRRKNYN 468
            .|||.|.|
Mouse   386 GRRRLNPN 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2972	NP_001285072.1	PIN_Nob1	11..120	CDD:189046	50/108 (46%)
		PIN_SF	<279..355	CDD:301351	42/75 (56%)
		NOB1_Zn_bind	319..390	CDD:285925	32/72 (44%)
Nob1	NP_080553.1	PIN_Nob1	7..115	CDD:189046	50/107 (47%)
		Nob1	8..292	CDD:224356	125/347 (36%)
		AF1Q	135..211	CDD:259154	26/133 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..201		8/29 (28%)
		NOB1_Zn_bind	251..323	CDD:285925	32/72 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845989
Domainoid	1	1.000	89	1.000	Domainoid score	I7898
eggNOG	1	0.900	-	-		E1_COG1439
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31924
Inparanoid	1	1.050	264	1.000	Inparanoid score	I3052
Isobase	1	0.950	-	0	Normalized mean entropy	S3224
OMA	1	1.010	-	-		QHG54261
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005109
OrthoInspector	1	1.000	-	-		oto93914
orthoMCL	1	0.900	-	-		OOG6_101333
Panther	1	1.100	-	-	LDO	PTHR12814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R821
SonicParanoid	1	1.000	-	-		X3629
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740