DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2972 and NOB1

DIOPT Version :9

Sequence 1:	NP_001285072.1	Gene:	CG2972 / 31943	FlyBaseID:	FBgn0030177	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_054781.1	Gene:	NOB1 / 28987	HGNCID:	29540	Length:	412	Species:	Homo sapiens

Alignment Length:	465	Identity:	168/465 - (36%)
Similarity:	255/465 - (54%)	Gaps:	70/465 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IKFLVADTTAFINAVPLNEYAEQVLTVPDVVAEVRNKRQIRRLCVLPFDLQVREPRPESIKHCVE 72
            ::.:|||..||:....|.:..:.:.|:.:||.|:|:|...|||.|||::|:.:||.||.::...|
Human     4 VEHVVADAGAFLRHAALQDIGKNIYTIREVVTEIRDKATRRRLAVLPYELRFKEPLPEYVRLVTE 68

  Fly    73 FAKKTGDYASLSGIDLKVISLTYELEADNVGTDHLRQEPVMAQTIASKDKPEEMQDANNKRLVGW 137
            |:||||||.|||..|::|::|||:|||:.||..||:|||...:..:|...||     ....:.|:
Human    69 FSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKQEPQKVKVSSSIQHPE-----TPLHISGF 128

  Fly   138 YMPEGEEEEEEDSEEEDDYSQEEDDAEGDEQEANESPDTVKAAIEAQLAGKEPFASETIEKEEDQ 202
            ::|   .:.:...|.|..:|..|             |:.::            |:|....:.
Human   129 HLP---YKPKPPQETEKGHSACE-------------PENLE------------FSSFMFWRN--- 162

  Fly   203 DQEPSQEELDKLFEQLKCAPSAEEEKELSELLVSQPAEVDEEVSEPQEAKQSQNLDEDVGDD--G 265
                               |....:.||.|||:.:..:|..| .|.:|....::..:|..||  |
Human   163 -------------------PLPNIDHELQELLIDRGEDVPSE-EEEEEENGFEDRKDDSDDDGGG 207

  Fly   266 WITHSNIKKAKKALEGKVETDEVPPVACMTTDYALQNVLKQLNLHLAALNGRIIKQLRTYILRCY 330
            |||.||||:.::.|| :.:..|...|.|:|||:|:||||.|:.||:.|:||.:|::.|:|||||:
Human   208 WITPSNIKQIQQELE-QCDVPEDVRVGCLTTDFAMQNVLLQMGLHVLAVNGMLIREARSYILRCH 271

  Fly   331 ACYKTTSIMTKVFCPNCGNKTLKRVAVSLDENGRQVIHINTRRP--LTNKYKNQSLPRFQGGKHS 393
            .|:||||.|::|||.:|||||||:|:|::.::|...:|. :|.|  |..:....|||..:|||::
Human   272 GCFKTTSDMSRVFCSHCGNKTLKKVSVTVSDDGTLHMHF-SRNPKVLNPRGLRYSLPTPKGGKYA 335

  Fly   394 RNPILFEDQPMPRQMPSRVAKTKTNALDQDYTAGFSPFVLRDVDSKSAMLRSKGNLKEWARNNNF 458
            .||.|.|||..|:...|:.|:.|||....||.||.||||..|:.|:||.|:        .|::..
Human   336 INPHLTEDQRFPQLRLSQKARQKTNVFAPDYIAGVSPFVENDISSRSATLQ--------VRDSTL 392

  Fly   459 EEDRRRKNYN 468
            ...|||.|.|
Human   393 GAGRRRLNPN 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2972	NP_001285072.1	PIN_Nob1	11..120	CDD:189046	49/108 (45%)
		PIN_SF	<279..355	CDD:301351	42/75 (56%)
		NOB1_Zn_bind	319..390	CDD:285925	33/72 (46%)
NOB1	NP_054781.1	PIN_Nob1-like	7..109	CDD:350224	49/101 (49%)
		WRNPLPNID	152..212	CDD:405671	19/94 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..208		7/28 (25%)
		NOB1_Zn_bind	260..332	CDD:400908	33/72 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155540
Domainoid	1	1.000	87	1.000	Domainoid score	I8055
eggNOG	1	0.900	-	-		E1_COG1439
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31924
Inparanoid	1	1.050	262	1.000	Inparanoid score	I3103
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54261
OrthoDB	1	1.010	-	-		D409120at33208
OrthoFinder	1	1.000	-	-		FOG0005109
OrthoInspector	1	1.000	-	-		oto90331
orthoMCL	1	0.900	-	-		OOG6_101333
Panther	1	1.100	-	-	LDO	PTHR12814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R821
SonicParanoid	1	1.000	-	-		X3629
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800