Protein Alignment ZAP3 and YLPM1

DIOPT Version :10

• Sequence 1: NP_001245607.1
• Gene: ZAP3 / 31942
• FlyBaseID: FBgn0052685
• Length: 1885
• Species: Drosophila melanogaster
• Sequence 2: NP_062535.2
• Gene: YLPM1 / 56252
• HGNCID: 17798
• Length: 2146
• Species: Homo sapiens
• Alignment Length: 2275
• Identity: 478/2275 - (21%)
• Similarity: 735/2275 - (32%)
• Gaps: 869/2275 - (38%)

  Fly     8 AAAVAPTAALPPQPSVPPPLPDAPPPPPPSDATAGAGASSGASAPIVTTAAAVTTAPGFNPYSSG 72
            |.:..|.:....:|.:|||..:.|||.||.:..: ......|....:..|||        .:...
Human   338 ATSQVPESPSSEEPPLPPPNEEVPPPLPPEEPQS-EDPEEDARLKQLQAAAA--------HWQQH 393

  Fly    73 QATGAGNPYQ---------QYTAAQYAAMTPE------------------QQYALQHHWQQW--- 107
            |....|..||         |....||..:...                  ||...||.:|:|
Human   394 QQHRVGFQYQGIMQKHTQLQQILQQYQQIIQPPPHIQTMSVDMQLRHYEMQQQQFQHLYQEWERE 458

  Fly   108 -----------------QTYQEEYAKW--HAQYGEQYKRE------------------------- 128
                             |.|::::..|  |.:..:.|.:|
Human   459 FQLWEEQLHSYPHKDQLQEYEKQWKTWQGHMKATQSYLQEKVNSFQNMKNQYMGNMSMPPPFVPY 523

  Fly   129 -----------------------MAAAAATTTAVQGVPAPVV---------------ATPAAAPV 155
                                   |..|...|....|:|.||:               :..:|.|.
Human   524 SQMPPPLPTMPPPVLPPSLPPPVMPPALPATVPPPGMPPPVMPPSLPTSVPPPGMPPSLSSAGPP 588

  Fly   156 PVVAPP-----GPQAYPVAHNYYQGVSASPAQSTTPVAVAGAPPL-----------PGKIMA-QP 203
            ||:.||     ||.  ||       :......||.|..|...|||           ||.... .|
Human   589 PVLPPPSLSSAGPP--PV-------LPPPSLSSTAPPPVMPLPPLSSATPPPGIPPPGVPQGIPP 644

  Fly   204 QMYNQPPPPPQKGGYNQHPNDIQSMWSGPPPMQQPPPNRYGGGQMNQMNYNIAGQDNQGFPNLQQ 268
            |:...|.||......:|.|..       |.|...|.|..:|.......:           |.||.
Human   645 QLTAAPVPPASSSQSSQVPEK-------PRPALLPTPVSFGSAPPTTYH-----------PPLQS 691

  Fly   269 PPPSLQ----RPTPQQQQPHLNHMDHGQWGNNQHGVGNN----NRPTWDTSGPP-------PD-- 316
            ..||.|    .|..:...|:.:.       ::..|:|.:    ::|.......|       ||
Human   692 AGPSEQVNSKAPLSKSALPYSSF-------SSDQGLGESSAAPSQPITAVKDMPVRSGGLLPDPP 749

  Fly   317 -----NTGQPNRWNGPPPANDVNNRW-----NGTSFNNNTNDGNR-RWDGTSNQA--------PS 362
                 .:.:..|::||....|:.:|.     .|..|..|..||.| |::|...:.        |.
Human   750 RSSYLESPRGPRFDGPRRFEDLGSRCEGPRPKGPRFEGNRPDGPRPRYEGHPAEGTKSKWGMIPR 814

  Fly   363 GGDQQ--------LNRWMSEPPPSLPNP--NQQYQNQNSWMSGPPPSISDPPQD---HQQQNNSS 414
            |...|        |:...|.|....|.|  .||:|.|....:.|.....:|..|   :||:|...
Human   815 GPASQFYITPSTSLSPRQSGPQWKGPKPAFGQQHQQQPKSQAEPLSGNKEPLADTSSNQQKNFKM 879

  Fly   415 QNA-------------------------------------RSSRW----QGINSDID-----TPP 433
            |:|                                     ..|.|    |.:.:.||     |.|
Human   880 QSAAFSIAADVKDVKAAQSNENLSDSQQEPPKSEVSEGPVEPSNWDQNVQSMETQIDKAQAVTQP 944

  Fly   434 MRTNNKPNSIQNSRNSWGDGGGDGNQSKNPFIKNPQSDFGNYG----NSYNSQDQG--------S 486
            :...|||...|::..| ..||.:|..:.........:||...|    :|.|:||:|        :
Human   945 VPLANKPVPAQSTFPS-KTGGMEGGTAVATSSLTADNDFKPVGIGLPHSENNQDKGLPRPDNRDN 1008

  Fly   487 AGGGNFGGFGDDSGGKQS--QDS------FAGRG----GGPGNNINNNFSN---NRRQNNRRDNN 536
            ...||.|......|..||  :|:      ..|||    .|||.....:|.:   .||:::|...|
Human  1009 RLEGNRGNSSSYRGPGQSRMEDTRDKGLVNRGRGQAISRGPGLVKQEDFRDKMMGRREDSREKMN 1073

  Fly   537 RNQGFSDE----------------RGGGDSGPGGYN----PNRGNYNQRNSFNQSNA-----PYK 576
            |.:|..|.                :|..|.|..|..    |.|....:|....::.:     |.:
Human  1074 RGEGSRDRGLVRPGSSREKVPGGLQGSQDRGAAGSRERGPPRRAGSQERGPLRRAGSRERIPPRR 1138

  Fly   577 QSQQNRN------------------------QQQPPDLDEASFDLLFDQ-----W----EQQFEE 608
            ...:.|.                        :.:|.|..|..:....|:     |    |:..||
Human  1139 AGSRERGPPRGPGSRERGLGRSDFGRDRGPFRPEPGDGGEKMYPYHRDEPPRAPWNHGEERGHEE 1203

  Fly   609 WKLANANHP---------DRDEY-RRYEEEFEKQRRRIAERREQMRRRRQLQMGGSAGGS-TTDI 662
            :.|...|.|         ||:.| |..|.:::.....:..|.::..........|...|. ..|.
Human  1204 FPLDGRNAPMERERLDDWDRERYWRECERDYQDDTLELYNREDRFSAPPSRSHDGDRRGPWWDDW 1268

  Fly   663 RKEAAAGASTTAEQKPNKD--------PFEGQGRFAD-QGDQDHGSGPNFGNGNRQSGNAGHFGK 718
            .::.........|.:.:.|        |.:...|..| :.|:|:|
Human  1269 ERDQDMDEDYNREMERDMDRDVDRISRPMDMYDRSLDNEWDRDYG-------------------- 1313

  Fly   719 ENRPFESAGVPAFRGNQGPPPGMHNQYQTAQEAIQQILDEQPDESNQEIPTKPAASNENSSDVKK 783
              ||                                 ||||..:..:.             |:
Human  1314 --RP---------------------------------LDEQESQFRER-------------DI-- 1328

  Fly   784 AKTTASPVAPPIAPVVPPEVKAPAAPVVPDPTVVPPTQPPPVSTNYGKRRQRAAPSQIPAKQVKE 848
                         |.:||               :||..|.|....|...|.|         :.:.
Human  1329 -------------PSLPP---------------LPPLPPLPPLDRYRDDRWR---------EERN 1356

  Fly   849 EEPIFTISLDDDDDDDEEKEVVQDAPNTPMGSIFK-KNDGIPGLDLVDDGSNKNNSSSVFNVVLK 912
            .|..:     |.|..|..:..:::.|.  .|..:: |.|.:|  |.:|....:          |.
Human  1357 REHGY-----DRDFRDRGELRIREYPE--RGDTWREKRDYVP--DRMDWERER----------LS 1402

  Fly   913 D----SSEKKAADETEKQP----------GDVSADKKGDESLSNALKDPNFINNLSQAVANVQER 963
            |    |...:.:...|..|          .|.|.|  .|:.|...:.       |||....:..:
Human  1403 DRWYPSDVDRHSPMAEHMPSSHHSSEMMGSDASLD--SDQGLGGVMV-------LSQRQHEIILK 1458

  Fly   964 EQRDRHEQRDDQESGTDGRPLSFAEWQRKKNSGNENKSQD---AGDSVSTNNGEKPDNNGPPGGF 1025
            ..::....|:.:|           :.|:.|:.|:|.:..|   ..:|...|...:|....|||.:
Human  1459 AAQELKMLREQKE-----------QLQKMKDFGSEPQMADHLPPQESRLQNTSSRPGMYPPPGSY 1512

  Fly  1026 GPGNGPGGGPGSGPGQNDGSRFDVFGPNQVSGNNFIDLDNNGPPGFG-PPGRNFGPNGPGPRGNF 1089
            .|                                        ||..| |||....|:.|..|.:.
Human  1513 RP----------------------------------------PPPMGKPPGSIVRPSAPPARSSV 1537

  Fly  1090 GPNFGHNFGPRGPGGPFIRPNGPLPGPGPNFGPHFRPNGPNFGPNFGPNFGPRPGSRNFGPRGPD 1154
                           |..||..|:|.|.|
Human  1538 ---------------PVTRPPVPIPPPPP------------------------------------ 1551

  Fly  1155 GPFGPGRDDFGGPPFGGPRPHMGPNGPG-----------------HNMRGFNGGPISDNPFRRQG 1202
                       .||...|.|.:.|....                 ::.:|.|      :.|:.:.
Human  1552 -----------PPPLPPPPPVIKPQTSAVEQERWDEDSFYGLWDTNDEQGLN------SEFKSET 1599

  Fly  1203 G--------PPGPGFGNDDLGAGPPRGPRNFGNRFGNPGGGGGGGGGGGNNNRKNWNDGPEQQQF 1259
            .        ||.|...:.     ||.||
Human  1600 AAIPSAPVLPPPPVHSSI-----PPPGP------------------------------------- 1622

  Fly  1260 HDRLNHNDAIYRPLKVFDYSNNPTAAKVIDYGH-KSGDGNPIDG-PSGS----NPDDRIPEFKAM 1318
                       .|:.:...|..|...:.:|||| :....|.::. |.|.    .||. :||   .
Human  1623 -----------VPMGMPPMSKPPPVQQTVDYGHGRDISTNKVEQIPYGERITLRPDP-LPE---R 1672

  Fly  1319 KTFEYGHSSYMGSNRLGMPGGMGGGGDHNQAMTGGRGMAAGPGRFGGPGGAGNK-RKNKKKNKQ- 1381
            .|||..|                                           ||.: |.:::::::
Human  1673 STFETEH-------------------------------------------AGQRDRYDRERDREP 1694

  Fly  1382 ----QKN--GELMTFNQNQQMQSNTVEERSITNPEQD--EEQRAHNELRNQNQADEFQKNEERND 1438
                |.|  .:...|.::::...:...:|.:.:.::|  :.:|...:.|.|:..|:...:..|..
Human  1695 YFDRQSNVIADHRDFKRDRETHRDRDRDRGVIDYDRDRFDRERRPRDDRAQSYRDKKDHSSSRRG 1759

  Fly  1439 LEDISEGEDNLQSIVFDDDNEELPPPPSMKIWNQGNAQEQYNPFPVNPLRRQLGDYSDKLEAPSP 1503
            ..|....:......|::.        |||....:....|:..|.|...|..|        ..|:|
Human  1760 GFDRPSYDRKSDRPVYEG--------PSMFGGERRTYPEERMPLPAPSLSHQ--------PPPAP 1808

  Fly  1504 AMSLFPSAANANDRTSDPMKASNLEMCVATSENRNTFSLDEVLLYPGRLNRPKRICIILRGPPGC 1568
            .:...|.:.|                            :|::|..|||.:||:||.:|:||.||.
Human  1809 RVEKKPESKN----------------------------VDDILKPPGRESRPERIVVIMRGLPGS 1845

  Fly  1569 GKSHVARLIKEKELEMGGANPRILSIDDYFLIENDYDEKCPKTGKKIPKKEILYEYDDTMEETYM 1633
            ||:|||:||::||:|.||..||:||:||||:.|.:.:||.|.:|||:.||.:.|||:..|||||.
Human  1846 GKTHVAKLIRDKEVEFGGPAPRVLSLDDYFITEVEKEEKDPDSGKKVKKKVMEYEYEAEMEETYR 1910

  Fly  1634 QYLIKSFKKTLSDNLYDFVIVDCNNNSLRTLNEFYCHAKDSNFVPYIVDLHCDLETCLGRNSHQR 1698
            ..:.|:|||||.|..:.|:|:|..|:.:|..::|:..||...|..|:.::..|.:||..||.|.|
Human  1911 TSMFKTFKKTLDDGFFPFIILDAINDRVRHFDQFWSAAKTKGFEVYLAEMSADNQTCGKRNIHGR 1975

  Fly  1699 SVNDIRVVLDNWCQTPTHYIKLDVSSLLENV----VEMEDVEDMATDDNACADVGATVGESAALE 1759
            .:.:|..:.|:|...|.|.::||:.|||::.    |||||.
Human  1976 KLKEINKMADHWETAPRHMMRLDIRSLLQDAAIEEVEMEDF------------------------ 2016

  Fly  1760 DAAVEE--TDDSNSADASNYCGFL-KSKWERDTTEDNLARLDGTKRLMQNRR-----TTSMADYL 1816
            ||.:||  .:..::.:..:..|:: |||||.||:|..|.:|||.:...:.:|     .:.|.|||
Human  2017 DANIEEQKEEKKDAEEEESELGYIPKSKWEMDTSEAKLDKLDGLRTGTKRKRDWEAIASRMEDYL 2081

  Fly  1817 QLEDWKPPTTSDNGKKRVRWADIEEKRSQKKMRAIGFVVGQTDWNRMMDPNA--GSRALNKTKFI 1879
            ||.|......|:.|||||||||:|||:...:.||||||||||||.::.|.:.  ..:|||:||:|
Human  2082 QLPDDYDTRASEPGKKRVRWADLEEKKDADRKRAIGFVVGQTDWEKITDESGHLAEKALNRTKYI 2146

  Fly  1880  1879
            Human  2147  2146

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZAP3	NP_001245607.1	AAA_33	1560..1702	CDD:463952	66/141 (47%)
YLPM1	NP_062535.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..381		12/43 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	562..880		78/351 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	895..1211		62/316 (20%)
		PRK12678	938..>1176	CDD:237171	49/238 (21%)
		PRK12678	1085..>1327	CDD:237171	43/309 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1243..1351		27/205 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1407..1438		6/32 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1469..1573		34/216 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1602..1828		55/369 (15%)
		AAA_33	1836..>1971	CDD:463952	62/134 (46%)
		Involved in interaction with PPP1CA. /evidence=ECO:0000250	2096..2103		6/6 (100%)