Protein Alignment ZAP3 and LOC3290429

DIOPT Version :10

• Sequence 1: NP_001245607.1
• Gene: ZAP3 / 31942
• FlyBaseID: FBgn0052685
• Length: 1885
• Species: Drosophila melanogaster
• Sequence 2: XP_551677.5
• Gene: LOC3290429 / 3290429
• VectorBaseID: AGAMI1_008102
• Length: 1278
• Species: Anopheles gambiae
• Alignment Length: 2067
• Identity: 442/2067 - (21%)
• Similarity: 641/2067 - (31%)
• Gaps: 978/2067 - (47%)

  Fly     5 WQTAAAVAPTAALPPQPSVPPPLPDAPPPPPPSDATAGAGASSGASAPIVTTAAAVTTAPGFNPY 69
            ||...:..|..|:.||  .|||||.....||              :.|:          ||:...
Mosquito     3 WQNNWSAMPPPAMNPQ--YPPPLPTTHTMPP--------------AVPL----------PGYGAV 41

  Fly    70 SSGQATGAGNPYQQYTAAQYAAMTPEQQYALQHHWQQWQTYQEEYAKWHAQYGEQYKREMAAAAA 134
            ::.|       |.|:                     |||.||::||:|:|.|||:|.::...|
Mosquito    42 NTDQ-------YNQW---------------------QWQQYQQQYAQWYAMYGEKYAQQTGNA-- 76

  Fly   135 TTTAVQGVPAPVVATPAAAPVPVVAPPGPQAYPVAHNYYQGVSASPAQSTTPVAVAGAPPLPGKI 199
                                :|.||.|.||:.|       .|.|:|..         |.|||
Mosquito    77 --------------------LPPVAAPMPQSVP-------NVLANPYV---------AAPLP--- 102

  Fly   200 MAQPQMYNQPPPPPQKGGYNQHPNDIQSMWSGPPPMQQPPPNRYGGGQMNQMNYNIAGQDNQGFP 264
                                          .||         .:|...|
Mosquito   103 ------------------------------VGP---------AFGSMSM---------------- 112

  Fly   265 NLQQPPPSLQRPTPQQQQPHLNHMDHGQWGNNQHGVGNNNRPTWDTSGPPPDNTGQPNRWNGPPP 329
             :..||||         :||.:.:..|:
Mosquito   113 -VAPPPPS---------EPHPDELRMGR------------------------------------- 130

  Fly   330 ANDVNNRWNGTSFNNNTNDGNRRWDGTSNQAPSGGDQQLNRWMSEPPPSLPNPNQQYQNQNSWMS 394
                                                      ::|.||
Mosquito   131 ------------------------------------------ITEKPP----------------- 136

  Fly   395 GPPPSISDPPQDHQQQNNSSQNARSSRWQGINSDIDTPPMRTNNKPNSIQNSRNSWGDGGGDGNQ 459
                    ||::
Mosquito   137 --------PPEE----------------------------------------------------- 140

  Fly   460 SKNPFIKNPQSDFGNYGNSYNSQDQGSAGGGNFGGFGDDSGGKQSQDSFAGRGGGPGNNINNNFS 524
                  |:|
Mosquito   141 ------KSP-------------------------------------------------------- 143

  Fly   525 NNRRQNNRRDNNRNQGFSDERGGGDSGPGGYNPNRGNYNQRNSFNQSNAPYKQSQQNRNQQQPPD 589
                                                                             
Mosquito   144 ----------------------------------------------------------------- 143

  Fly   590 LDEASFDLLFDQWEQQFEEWKLANANHPDRDEYRRYEEEFEKQRRRIAERREQMRRRRQLQMGGS 654
             :|.:||..|.:|||:||.||..|.||||:..||.||:::|:||:::.:.|||:|||::
Mosquito   144 -EEIAFDEQFRKWEQEFETWKRTNINHPDKAAYREYEQKYEEQRKKLLDHREQLRRRKR------ 201

  Fly   655 AGGSTTDIRKEAAAGASTTAEQKPNKDPFEGQGRFADQGDQDHGSGPNFGNGNRQSGNAGHFGKE 719
                           |.:.|.|.|                  |.|..:.
Mosquito   202 ---------------AHSAASQPP------------------HSSALSI---------------- 217

  Fly   720 NRPFESAGVPAFRGNQGPPPGMHNQYQTAQEAIQQILDEQPDESNQEIPTKPAASNENSSDVKKA 784
                         ..|.|||.                           |.:||.
Mosquito   218 -------------SLQKPPPP---------------------------PPQPAQ----------- 231

  Fly   785 KTTASPVAPPIAPVVPPEVKAPAAPVVPDPTVVPPTQPPPVSTNYGKRRQRAAPSQIPAKQVKEE 849
                   .||..|..||:                |:|||            ..|.|.|.......
Mosquito   232 -------PPPQPPSEPPQ----------------PSQPP------------RPPGQEPTNCSSNT 261

  Fly   850 EPIFTISLDDDDDDDEEKEVVQDAPNT-PMGSIFK------KNDGIPGLDLVDDGSNKNNSSSVF 907
            .|..|..:.:::    ......||.|: .:.::|.      ::.|||||||:|:........:..
Mosquito   262 TPASTGGMAEEN----THHAGSDAANSMHLHNLFSSPSKAGRDGGIPGLDLIDETPQPVPKKAKL 322

  Fly   908 NVVLKDSSEKKAADETEKQPGDVSADKKGDESLSNALKDPNFINNLSQAVANVQEREQRDRHEQR 972
            :..:.|.|.:   :|..|:|.........|..:|..|.||| :|.|.|.|
Mosquito   323 DENVIDLSNE---EEESKEPKPKETKPSPDNMISTLLNDPN-VNALLQLV--------------- 368

  Fly   973 DDQESGTDGRPLSFAEWQRKKNSGNENKSQDAGDSVSTNNGEKP--------DNNGPPGGFGPGN 1029
                    |:.:|               :..||.|.|..|...|        .:|..|....| :
Mosquito   369 --------GKTIS---------------ANGAGGSASGANAPNPLVAALAQLTSNTNPATLEP-S 409

  Fly  1030 GPGGGPGSG------PGQNDGSRFDVFGPNQVSGNNFIDLDNNG----PPGFGPPGRNFGPNGPG 1084
            .|...|.:|      |..| .|||                  ||    ||       :...:|.|
Mosquito   410 MPNERPANGMVERNEPHPN-ASRF------------------NGSKEQPP-------STMQSGGG 448

  Fly  1085 PRGNFGPNFGHNFGPRGPGGPFIRP---NGPLPGPGPNFGPHFRPNGPNFGPNFGPNFGPRP--- 1143
            ......|..|....|:| ..|::.|   :..|..|.|...|              |....||
Mosquito   449 GTTEECPTAGFRNRPQG-FNPYVPPPLVDVDLSRPPPMLLP--------------PGNNNRPQRD 498

  Fly  1144 -GSRNFGPRGPDGPFGPGRDDFGG-----PPFGGPRPHMGPNGPGHNMRGFNGGPISDNPFRRQG 1202
             .|||......:|.|..|....|.     |.|..|.|....|.|.:.:....|.|::
Mosquito   499 RSSRNSDATSENGSFNDGYSGDGSPLPKIPRFDRPPPTFAANHPEYEIDPELGRPVA-------- 555

  Fly  1203 GPPGPGFGNDDLGAGPPRGPRNFGNRFGNPGGGGGGGGGGGNNNRKNWNDGPEQQQFHDRLNH-- 1265
             .|.|                                         .|....|.|:.:||..|
Mosquito   556 -VPKP-----------------------------------------QWMTEEEYQEIYDRYEHVQ 578

  Fly  1266 --------------------------------------------------------NDAIYRPLK 1274
                                                                    .|..::|.:
Mosquito   579 SFDERKNKMLLAIQVLKTSKLRAGMLLEPPPDEVNRVPVAMPKPLPPVKTPIKSEPVDDYFQPQQ 643

  Fly  1275 VFDYSN----NPTAA------KVIDYGHK-----SGDGNPIDGPSGSNPDDRIPEFKAM------ 1318
            ||||||    .|.|:      :||||||:     :.:.|.:      |.:.|..||:.|
Mosquito   644 VFDYSNCRNTRPVASQQLPTGRVIDYGHRGVNQYTANNNRL------NSNSRRDEFRGMNNNARG 702

  Fly  1319 -----------KTFEYGHSSYMGSNRLGMP---------GGMGGGGDHNQAMTGGRGMAA----- 1358
                       :.|:|.||....:.....|         .......|  :::||...:|.
Mosquito   703 GANENGFGTNTQRFDYNHSRVANAPPTTAPLQQNQQWPLSNQSAAQD--RSVTGLERLAQMHLNP 765

  Fly  1359 --------GPGRF-----GGPGGAGNK--------RKNKKKNKQQKNGELMTFNQNQQMQSNTVE 1402
                    .|.:|     ..|.....|        ||.|.|..||:.      .|.||.|...::
Mosquito   766 NPEESNPNYPSKFLLMNDNRPNCLSTKRGKRPSSIRKQKLKQLQQQQ------QQQQQEQQQQLD 824

  Fly  1403 ERSITNPEQDEEQRAHNELRNQNQADEFQ-----KNEERNDLEDISEGEDNLQSIVFDDDNEELP 1462
            ::.  .|:|..|.:|........|::...     |.|....|||:|..||.|.    |.|:
Mosquito   825 QQQ--QPQQQPEPKAGQPEPEPAQSEPMPSPMVCKQEPEMHLEDLSSDEDGLP----DGDD---- 879

  Fly  1463 PPPSMKIWNQGNAQEQYNPFPVNP-LRRQLGDYSDKLEAPSPAMSLFPSAANANDRTSDPMKASN 1526
                      |.|. |.|...|.| ::::|.|  |:.|:|..::|              ....|.
Mosquito   880 ----------GFAY-QSNDECVKPAIKQELLD--DRPESPVSSLS--------------SQNLSP 917

  Fly  1527 LEMCVATSENRNTFSLDEVLLYPGRLNRPKRICIILRGPPGCGKSHVARLIKEKELEMGGANPRI 1591
            ::|          ..::::||.|||..||.|||.::||.||.||||:|||||.|| :..|.:||:
Mosquito   918 IQM----------IDIEDLLLPPGRYQRPLRICFLIRGLPGSGKSHLARLIKNKE-QSFGQSPRV 971

  Fly  1592 LSIDDYFLIENDYDEKCPKTGKKIPKKEILYEYDDTMEETYMQYLIKSFKKTLSDNLYDFVIVDC 1656
            ||:|||||::.:.:||...||:.......|||:|..||:.|:|.|:|:||:|:|:.|:|||||||
Mosquito   972 LSLDDYFLVDKEEEEKDLVTGRITKLTRSLYEFDAEMEDVYVQNLLKAFKRTISERLFDFVIVDC 1036

  Fly  1657 NNNSLRTLNEFYCHAKDSNFVPYIVDLHCDLETCLGRNSHQRSVNDIRVVLDNWCQTPTHYIKLD 1721
            .|:.|.|..||:.:|:.:.|..|...:..|:|.|..:|.|.|:..:|:...|||...|..:::::
Mosquito  1037 CNHRLETYCEFHNYARSNGFKVYTCTMQTDVEDCARQNIHNRTEAEIQAYADNWAMAPDDHVQIN 1101

  Fly  1722 VSSLLENVVEMEDVEDMATDDNACADVGATVGESAALEDAAVEET-----DDSNS--ADASNYCG 1779
            .:||||..:: |:.:.|..|...   |||...|....:|..:.|.     ||||.  ||.:..|.
Mosquito  1102 FNSLLEPELQ-EETDTMVADMEL---VGADEEEPYGADDQGLLEQISTSHDDSNDSFADGTAECD 1162

  Fly  1780 FLKSKWERDTTEDNLARLDGTKRLMQNRRTTSMADYLQLEDWKPP-----------TTSDNGKKR 1833
            ...|||:.|.:|.||||||||.:.:  :|..::.|||||:|....           :.|...|||
Mosquito  1163 LFASKWDHDASEQNLARLDGTSKPL--KRPPTLEDYLQLDDGNADEQQEDECQDGFSKSGGKKKR 1225

  Fly  1834 VRWADIEEKRSQKKMRAIGFVVGQTDWNRMMDPNAGSRALNKTKFIERIKRR 1885
            |||||:||:::|:|||.:|||||.|||.|||||:.||.||.:||:|||:|::
Mosquito  1226 VRWADVEERKAQEKMRQLGFVVGVTDWRRMMDPSEGSSALTQTKYIERVKKQ 1277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZAP3	NP_001245607.1	AAA_33	1560..1702	CDD:463952	65/141 (46%)
LOC3290429	XP_551677.5	None