Protein Alignment ZAP3 and glh-4

DIOPT Version :10

• Sequence 1: NP_001245607.1
• Gene: ZAP3 / 31942
• FlyBaseID: FBgn0052685
• Length: 1885
• Species: Drosophila melanogaster
• Sequence 2: NP_491207.3
• Gene: glh-4 / 171941
• WormBaseID: WBGene00001601
• Length: 1156
• Species: Caenorhabditis elegans
• Alignment Length: 1344
• Identity: 262/1344 - (19%)
• Similarity: 394/1344 - (29%)
• Gaps: 488/1344 - (36%)

  Fly   802 EVKAPAAPVVPDPTVVPPTQPP--PVSTNYGKRRQRAAPSQIPAKQVKEEEPIFTISLDDDDDDD 864
            |.:...|..||:..|.||.:||  |.||......:|           ..:||.....:|......
 Worm    11 EAEVKVAEDVPEKNVPPPVEPPRAPQSTAIKTEPER-----------NSDEPSAGFGIDPITTSK 64

  Fly   865 EEKEVVQDAPNTPMGSIFKKNDGIPGLDLVDDGSNKNNSSSVFNVVLKDSSEKKAADETEKQPGD 929
            ....  |..|.|..|       |.|.|    .|...|.:::..|        |.:.|  ::..|.
 Worm    65 TFGS--QTTPKTEFG-------GAPSL----SGFGGNAAAAAAN--------KTSFD--QQGNGF 106

  Fly   930 VSADKKGDESLSNALK-----------------------DPNFINNLSQAVANVQEREQRDR--- 968
            ..|.|.|...:..|..                       :|..::  ..|.::....:|:|:
 Worm   107 GGAAKHGFGGVGGAPSSFGANVIPVNKPSLGHKTTGFGGEPKHVS--GGAFSSANNFDQQDKGFG 169

  Fly   969 -------------HEQRDDQESGTDG---------RPLSFAE---------WQRKKNSGNENKS- 1001
                         ..|:...|:.|.|         :|.||.:         ...|...|..:.|
 Worm   170 GAASSGFGNGSMLTNQKVGLENQTTGVGASEVPTSKPSSFGQQPAVVSGFGGAAKMGFGGSSSSG 234

  Fly  1002 ---QDAGDSVSTNNGEKPDNNGPPG-------GFGPGNGPG-GGPGSGPGQNDGSRFDVFGPNQV 1055
               |.||.:.|:....|..:...||       |||.|...| ||.|:|..:|.|.      |.:.
 Worm   235 FGGQKAGATESSGFPTKETSTSQPGFGGDSSTGFGSGLKAGFGGHGAGAAENSGL------PTET 293

  Fly  1056 SG------NNFIDLDNNGPPGFGPPGRNFG---PNGPGPRGNFGPNFGH----NFGPRGPGGPFI 1107
            :|      :......::....||...:.||   .||.|  |:...:||.    .||.....|
 Worm   294 TGFGGKLPSAGFGASSSNESAFGQQSKGFGGATKNGFG--GDSSSSFGSGSKAGFGGTSSSG--- 353

  Fly  1108 RPNGPLPGPGPNFGPHFRPNGPNFGPNFGPNFGPRPGSRNFG-PRGPDGPFGPGRDDFGG---PP 1168
             ..|..||...:.|...:....: |..||..||.:|.|..|| |...|...|.....|||   |.
 Worm   354 -IGGQKPGATESSGFPTKETSTS-GGTFGSGFGGKPTSTGFGAPSTTDSSSGQQTAGFGGASKPG 416

  Fly  1169 FGG---------------------------PRPHMGPNGP----------------GHNMRGFNG 1190
            |||                           |....|..|.                |...:||.|
 Worm   417 FGGDSSTGFGSGLKAGFGGHRASTAENSGLPTETTGFGGKLPPAGFGASSSNESAFGQQSKGFGG 481

  Fly  1191 ------GPISDNPFRRQ----GGPPGPGFGNDDLGAGPPRGPRNFG-----NRFGNPGGGGGGGG 1240
                  |..|.|.|.::    |||...|||:.|..:....|..|.|     :.||..|.|.....
 Worm   482 ATKNGFGGDSSNSFGKRDSGFGGPQDQGFGDTDAPSKSGLGSFNTGGGAVKSAFGAAGFGSSSNF 546

  Fly  1241 GGGN-------NNRKNWNDGPEQQQFHDRLNHNDAIYRPLKVFDYSNNPTAAKVIDYGHKSGDGN 1298
            |.||       |.|.||:.|...:..|:                         ..:.||.|.:
 Worm   547 GNGNTFGEPSDNQRGNWDGGERPRGCHN-------------------------CGEEGHISKE-- 584

  Fly  1299 PIDGPSGSNPDDRIPEFKAMKTFEYGH-SSYMGSNRL--------GMPGGMGGGGDHNQAMTGGR 1354
             .|.|       ::|.|......:.|| :|.....|:        |:.|......|..:
 Worm   585 -CDKP-------KVPRFPCRNCEQLGHFASDCDQPRVPRGPCRNCGIEGHFAVDCDQPK------ 635

  Fly  1355 GMAAGPGRFGGPGGAGNKRKNKKKNKQQKNGELMTFNQNQQMQSNTVEERSITNPEQDEEQRAH- 1418
             :..||.|..|                 :.|......||::::...      |.|.:...:..|
 Worm   636 -VPRGPCRNCG-----------------QEGHFAKDCQNERVRMEP------TEPCRRCAEEGHW 676

  Fly  1419 --------NELR-NQNQADEFQKNEERNDLEDISEGEDNL---QSIVFDDDNEELPPPPSMKIWN 1471
                    .:|: |..::.:|....:....||....:|.:   |.:|......|:|...|
 Worm   677 GYECPTRPKDLQGNFLESYDFVFTPDDKMFEDAVNNDDKIDFDQKVVASTGKVEIPDMAS----- 736

  Fly  1472 QGNAQEQYNPFPVNP------LRRQLGDYSDKLEAPSPAM--SLFPSAANAND------------ 1516
                   ::.|.:.|      |:|.      |:..|:|..  |.|| ..:.||
 Worm   737 -------FDGFKILPQDLHDNLKRM------KMNRPTPIQRASFFP-IMHGNDVVACAHTGSGKT 787

  Fly  1517 -------------------RTSDPMKASNLEMCVATSENRN-TFSLDEVLLYPGRLNRPKRICII 1561
                               ..:|...:..|.:...|.|..| ||:....|.|...|.
 Worm   788 LAFLIPFVIKLMEEFEKDRDVTDEKPSPRLLIVAPTRELVNQTFTTARQLTYETGLK-------- 844

  Fly  1562 LRGPPGCG--------KSHVARL-------------------IKEKELEMGGANPRILSIDDYFL 1599
                  ||        .::|..|                   :...|:.:......:|...|..:
 Worm   845 ------CGLAFGGYSRNANVQHLRSFSQLNILVATMGRLQDFVNAGEVSLSKMKYIVLDEADRMV 903

  Fly  1600 IENDYDEKCPKTGKKIPKKEILYEYDDTMEETYMQYLIKSFKKTL-SDNL-------YDFVIVDC 1656
            ..||:.|:..|         |:....:..::|.:  ...||.:.| ||:|       |..:.||
 Worm   904 DSNDFGEEVSK---------IIGSPGERTQQTVL--FSASFSEDLQSDDLPKFVKEGYTMLQVD- 956

  Fly  1657 NNNSLRTLNE------------------FYCHAKDSNFVPYIVDLHCDLETCLGRNSHQRSVNDI 1703
               ...|.||                  :.....|.|.|..:.|...:.:..|      ..||.:
 Worm   957 ---KFGTANEKIDQKILPVPRTEKRDAIYKLLGIDENTVTLLPDAPIEKQKTL------IFVNSV 1012

  Fly  1704 RVVLDNWCQTPTHYI-KLDVSSLLENVVEMEDVEDMATDD------------NACADVGATVGES 1755
            :     :|.|....| ...||::..:..:.::..|...||            |.||. |..:
 Worm  1013 K-----FCDTLAALISSAGVSTISMHSYQNQEQRDRTLDDFRRGKYQCMVASNVCAR-GLNI--- 1068

  Fly  1756 AALEDAAVEETDDSNSADASNYCGFLKSKWERDTTEDNLARLDGTKRLMQNRRTTSMADYLQLED 1820
            |.|:.....:..|.|        ||          ::.:.|:..|.|......:|:..|.....|
 Worm  1069 AGLDHVVNYDMPDKN--------GF----------DEYVNRIGRTGRAGFTGTSTAFVDVENDTD 1115

  Fly  1821 WKPPTTS--DNGKKRV-RWADIEEKRSQKKMRAIGFVVGQTDWN 1861
            ..|...|  :..||.| .|. .|....|::        |..|||
 Worm  1116 IIPCLVSILNEAKKEVPEWL-TEGAGHQEE--------GGDDWN 1150

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZAP3	NP_001245607.1	AAA_33	1560..1702	CDD:463952	31/194 (16%)
glh-4	NP_491207.3	dermokine	<388..>590	CDD:455732	52/236 (22%)
		PTZ00368	572..685	CDD:173561	25/177 (14%)
		SrmB	734..1109	CDD:440279	77/455 (17%)