Protein Alignment CG15312 and robo1

DIOPT Version :10

• Sequence 1: NP_001245603.1
• Gene: CG15312 / 31940
• FlyBaseID: FBgn0030174
• Length: 464
• Species: Drosophila melanogaster
• Sequence 2: NP_476899.1
• Gene: robo1 / 37603
• FlyBaseID: FBgn0005631
• Length: 1395
• Species: Drosophila melanogaster
• Alignment Length: 556
• Identity: 110/556 - (19%)
• Similarity: 167/556 - (30%)
• Gaps: 232/556 - (41%)

  Fly    39 KGGNVSIPCIAQGN----IMWVKE-H----GNNSTIVQTGRVLVLRNVSTTDAGIYVCFASVPRP 94
            ||...::||.|.||    |.|..: |    ||..:|:| |..|.:.::..:|:|.|.|.||..|.
  Fly   458 KGSVATLPCRATGNPSPRIKWFHDGHAVQAGNRYSIIQ-GSSLRVDDLQLSDSGTYTCTASGERG 521

  Fly    95 STT--AT-----SATTSPQNLQDKETRPLEDEDDGQGESVSPKDDQLKEAEMEEEVEYLAHQRTK 152
            .|:  ||     ..:||.....|..|.|        ....:||              .|...||.
  Fly   522 ETSWAATLTVEKPGSTSLHRAADPSTYP--------APPGTPK--------------VLNVSRTS 564

  Fly   153 LIVRTVPGPVSQLYFKASTILGFLIWRFNKTQSGGY-PVRSFTAEYRNVSYKTPPANASFEHAWS 216
            :.:|                     |..::.:.|.. |:..:|.||.:...:|         .|
  Fly   565 ISLR---------------------WAKSQEKPGAVGPIIGYTVEYFSPDLQT---------GW- 598

  Fly   217 RMDPINIAFNV--RQMEVYRLAPNTTYEFRIWANNELG----SGEVVTTNVTTLPETKEEDLIRL 275
                |..|..|  .|:.:..|.|.|:|.|.:.|.|..|    ||         |..|     |:.
  Fly   599 ----IVAAQRVGDTQVTISGLTPGTSYVFLVRAENTQGISVPSG---------LSNT-----IKT 645

  Fly   276 IKPDLDNFDPRIWIVAVSIVLGTLVIL----AI---------------------GLCIVLSKECY 315
            |:.|.|.........|.:::.|..|.|    ||                     ||.|.......
  Fly   646 IEADFDAASANDLSAARTLLTGKSVELIDASAINASAVRLEWMLHVSADEKYVEGLRIHYKDASV 710

  Fly   316 QSAQ---MELQDGWDSIELIPNI--------ILNPGFSESDGGPEPGGQGHGGSAGDQDAGEDDD 369
            .|||   :.:.|......::.|:        .|.|.|...:|.|     .:..:|...
  Fly   711 PSAQYHSITVMDASAESFVVGNLKKYTKYEFFLTPFFETIEGQP-----SNSKTALTY------- 763

  Fly   370 DDVAMPFPRTIIFGQHHR-------TPPPPRLH-------------------------------- 395
            :||....|..|..|.:::       ||||.:.|
  Fly   764 EDVPSAPPDNIQIGMYNQTAGWVRWTPPPSQHHNGNLYGYKIEVSAGNTMKVLANMTLNATTTSV 828

  Fly   396 ---------------------------------LPPQHHRHQNQSH----HHQYHHQQNQQQHHH 423
                                             :.|.||.|..::|    |...|..|:...|::
  Fly   829 LLNNLTTGAVYSVRLNSFTKAGDGPYSKPISLFMDPTHHVHPPRAHPSGTHDGRHEGQDLTYHNN 893

  Fly   424 HHLRRQDDDDDDDYEEEHEPTMERFKRKVSVFFTGP 459
            .::...|.:          ||..   :|.:.:.:||
  Fly   894 GNIPPGDIN----------PTTH---KKTTDYLSGP 916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15312	NP_001245603.1	Ig	39..90	CDD:472250	20/59 (34%)
		Ig strand B	43..47	CDD:409358	0/3 (0%)
		Ig strand C	52..56	CDD:409358	2/7 (29%)
		Ig strand F	84..89	CDD:409358	2/4 (50%)
robo1	NP_476899.1	Ig	56..151	CDD:472250
		Ig strand B	73..77	CDD:409353
		Ig strand C	86..90	CDD:409353
		Ig strand E	111..115	CDD:409353
		Ig strand F	129..134	CDD:409353
		Ig strand G	143..146	CDD:409353
		IgI_2_Robo	158..251	CDD:409389
		Ig strand A	158..161	CDD:409389
		Ig strand A'	163..167	CDD:409389
		Ig strand B	171..178	CDD:409389
		Ig strand C	186..191	CDD:409389
		Ig strand C'	193..196	CDD:409389
		Ig strand D	209..213	CDD:409389
		Ig strand E	216..222	CDD:409389
		Ig strand F	229..237	CDD:409389
		Ig strand G	240..251	CDD:409389
		IgI_3_Robo	258..341	CDD:409390
		Ig strand A	258..261	CDD:409390
		Ig strand A'	263..267	CDD:409390
		Ig strand B	270..279	CDD:409390
		Ig strand C	285..290	CDD:409390
		Ig strand C'	293..296	CDD:409390
		Ig strand D	299..304	CDD:409390
		Ig strand E	305..313	CDD:409390
		Ig strand F	320..328	CDD:409390
		Ig strand G	331..341	CDD:409390
		Ig	346..437	CDD:472250
		Ig strand B	362..366	CDD:409353
		Ig strand C	375..379	CDD:409353
		Ig strand E	402..406	CDD:409353
		Ig strand F	416..421	CDD:409353
		Ig strand G	429..432	CDD:409353
		Ig	446..531	CDD:472250	26/73 (36%)
		Ig strand B	462..466	CDD:409544	0/3 (0%)
		Ig strand C	475..479	CDD:409544	1/3 (33%)
		Ig strand E	497..501	CDD:409544	1/3 (33%)
		FN3	507..>916	CDD:442628	92/504 (18%)
		Ig strand F	511..516	CDD:409544	2/4 (50%)
		Ig strand G	524..527	CDD:409544	0/2 (0%)
		FN3	549..637	CDD:238020	27/144 (19%)
		fn3	770..855	CDD:394996	8/84 (10%)