DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht6 and CTS2

DIOPT Version :9

Sequence 1:	NP_001245598.1	Gene:	Cht6 / 31935	FlyBaseID:	FBgn0263132	Length:	4611	Species:	Drosophila melanogaster
Sequence 2:	NP_010659.1	Gene:	CTS2 / 851977	SGDID:	S000002779	Length:	511	Species:	Saccharomyces cerevisiae

Alignment Length:	453	Identity:	122/453 - (26%)
Similarity:	210/453 - (46%)	Gaps:	120/453 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 YYTNWSVYRPGTAKFN-PQNINPYLCTHLVYAF-------GGFTKDNQMKPFDKYQDIEQGGYAK 91
            ||:|||.|:|   :|: |.:||....:|:.|||       ||      ::..|.:.|:|...| |
Yeast    78 YYSNWSPYKP---RFHFPHDINLKQVSHIYYAFFKINSRTGG------IENTDSWSDLEMNLY-K 132

  Fly    92 FTGLKT-------------------------------YNKQLKTMIAIGGWNEASSRFSPLVASN 125
            ...:|.                               .:|:.|.:::||||:: |..|..::..:
Yeast   133 SLAIKNSELIKESSNNSVQNILPLGCIGELFYLKNTCSDKKFKVIMSIGGWSD-SENFKIIIKDD 196

  Fly   126 ERRQQFIKNILKFLRQNHFDGIDLDWEYPAHREGGKSRDRDNYAQFVQELRAEFER-EAEKTGR- 188
            :..|.|:.:.::.:.:..|||||||||:|.:.|   |..| .|.:.|:.||.:... |::..|:
Yeast   197 KLLQNFVDSSVETMFRLGFDGIDLDWEFPGNNE---SEPR-GYLKLVRMLRLKLNSLESQIFGKR 257

  Fly   189 --TRLLLTMAVPAGIEYIDKGYDVP--KLNKYLDWFNVLTYDFHSSHEPSVNHHAPLYSLEEDSE 249
              ....|::|.||   :.||.:.:|  ::::|:|::|::|||::.|...:..:|:.|:|
Yeast   258 TEDHFQLSIAAPA---FKDKLFYLPITEIDQYVDYWNMMTYDYYGSWSETTGYHSNLFS------ 313

  Fly   250 YNYDAELNIDYSIKYYL-KAGADRDKLVLGIPTYGRSY--------------TLINEESTELGAP 299
               :.|||.::::.|.: :.|.:..|||||:..||||:              .|||:....:|.|
Yeast   314 ---ETELNGNFAMHYMIDRFGVNSRKLVLGMAAYGRSFHIKDNKFEPFNQNTVLINKIFKGVGKP 375

  Fly   300 AEGPGEQGDATREKGYLAYYEICQTLKDDPE-WTVVQPNANVMGPYAY--RRNQWVGYDDEAIVR 361
            .:   |...|..::|...|       |:.|: .|:.|.:...:..|.:  :.:.::.||:...|:
Yeast   376 TK---EIDKADGKEGIWPY-------KNLPKIGTIEQYDPKYVSAYCFDEKNSIFISYDNTKSVK 430

  Fly   362 KKAEYVVAQGLGGIMFWAIDNDDFRGTCNGKPY-----PLIEAAKEAMVEALGLGINEVAKPS 419
            .|||||....|||..:|.        :| |:.|     .||.|..|      ||..|..:|||
Yeast   431 TKAEYVTHNNLGGGFWWE--------SC-GEAYANESRSLINAFNE------GLHFNVSSKPS 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht6	NP_001245598.1	Glyco_18	31..383	CDD:214753	109/410 (27%)
		GH18_chitolectin_chitotriosidase	32..404	CDD:119351	116/436 (27%)
		CBM_14	506..562	CDD:279884
		Oxidored_q2	<2691..2750	CDD:294335
		CBM_14	4554..4609	CDD:279884
CTS2	NP_010659.1	ChiA	36..474	CDD:225862	119/447 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I1191
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	1	1.000	-	-		otm46727
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2066
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840