DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht6 and Chia1

DIOPT Version :9

Sequence 1:	NP_001245598.1	Gene:	Cht6 / 31935	FlyBaseID:	FBgn0263132	Length:	4611	Species:	Drosophila melanogaster
Sequence 2:	NP_075675.2	Gene:	Chia1 / 81600	MGIID:	1932052	Length:	473	Species:	Mus musculus

Alignment Length:	549	Identity:	190/549 - (34%)
Similarity:	287/549 - (52%)	Gaps:	85/549 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LFLLCALAYCIN-EASSEGRVVCYYTNWSVYRPGTAKFNPQNINPYLCTHLVYAFGGFTKDNQMK 76
            |.|:..||..:| :..|...::||:|||:.||||...|.|.:|||.|||||:|||.|. ::|::.
Mouse     4 LLLVTGLALLLNAQLGSAYNLICYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGM-QNNEIT 67

  Fly    77 PFDKYQDIEQGGYAKFTGLKTYNKQLKTMIAIGGWNEASSRFSPLVASNERRQQFIKNILKFLRQ 141
            ..: :.|:..  |..|..||..|.:|||::||||||..::.|:.:|::::.||.||.:::|||||
Mouse    68 TIE-WNDVTL--YKAFNDLKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSVIKFLRQ 129

  Fly   142 NHFDGIDLDWEYPAHREGGKSRDRDNYAQFVQELRAEFEREAEKTGRTRLLLTMAVPAGIEYIDK 206
            ..|||:|||||||..| |...:|:..:...|:|:|..||:||.::.|.||::|.||..||..|..
Mouse   130 YGFDGLDLDWEYPGSR-GSPPQDKHLFTVLVKEMREAFEQEAIESNRPRLMVTAAVAGGISNIQA 193

  Fly   207 GYDVPKLNKYLDWFNVLTYDFHSSHEPSVNHHAPLYSLEEDSEYNYDAELNIDYSIKYYLKAGAD 271
            ||::|:|:||||:.:|:|||.|.|.|.....::|||....::..|  |.||:||.:.|:...||.
Mouse   194 GYEIPELSKYLDFIHVMTYDLHGSWEGYTGENSPLYKYPTETGSN--AYLNVDYVMNYWKNNGAP 256

  Fly   272 RDKLVLGIPTYGRSYTLINEESTELGAPAEGPGEQGDATREKGYLAYYEICQTLKDDPE--WTVV 334
            .:||::|.|.||.::.|.|.....:|||..|.|..|..||:.|:.||||||..|:....  |
Mouse   257 AEKLIVGFPEYGHTFILRNPSDNGIGAPTSGDGPAGPYTRQAGFWAYYEICTFLRSGATEVW--- 318

  Fly   335 QPNANVMGPYAYRRNQWVGYDDEAIVRKKAEYVVAQGLGGIMFWAIDNDDFRGT-CNGKPYPLIE 398
              :|:...||||:.|:|:|||:......||:::.....||.|.||||.|||.|: |:...:||
Mouse   319 --DASQEVPYAYKANEWLGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCDQGKFPL-- 379

  Fly   399 AAKEAMVEALGLGINEVAKPSGPQKPSRSRSRDNASNRNRLNGKTEAPLSSRRPSATRRPAVSST 463
              ...:.:|||:.......|..|.:|                                      .
Mouse   380 --TSTLNKALGISTEGCTAPDVPSEP--------------------------------------V 404

  Fly   464 QAPPPSTTFKLTEAEGSSLYIGGRASTTPPPPTTPDPGSDFKCEE-EGFFQHPRDCKKYYWCLDS 527
            ..||.|.:     ..|||   ||.:.           ||.|..:: :|.:....|...::.|:
Mouse   405 TTPPGSGS-----GGGSS---GGSSG-----------GSGFCADKADGLYPVADDRNAFWQCI-- 448

  Fly   528 GPSGLGIVAHMFTCPSGLYFNPAADSCDF 556
              :|:....|   |.:||.|:.:.:.|::
Mouse   449 --NGITYQQH---CQAGLVFDTSCNCCNW 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht6	NP_001245598.1	Glyco_18	31..383	CDD:214753	150/353 (42%)
		GH18_chitolectin_chitotriosidase	32..404	CDD:119351	157/374 (42%)
		CBM_14	506..562	CDD:279884	10/52 (19%)
		Oxidored_q2	<2691..2750	CDD:294335
		CBM_14	4554..4609	CDD:279884
Chia1	NP_075675.2	GH18_chitolectin_chitotriosidase	24..387	CDD:119351	157/378 (42%)
		Glyco_18	24..365	CDD:214753	150/352 (43%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	70..71		0/1 (0%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	97..100		2/2 (100%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	210..213		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..421		11/72 (15%)
		ChtBD2	426..473	CDD:214696	11/54 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2066
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850