DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht6 and chia.2

DIOPT Version :9

Sequence 1:	NP_001245598.1	Gene:	Cht6 / 31935	FlyBaseID:	FBgn0263132	Length:	4611	Species:	Drosophila melanogaster
Sequence 2:	NP_998414.1	Gene:	chia.2 / 406338	ZFINID:	ZDB-GENE-040426-2014	Length:	470	Species:	Danio rerio

Alignment Length:	551	Identity:	188/551 - (34%)
Similarity:	278/551 - (50%)	Gaps:	99/551 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLCALAYCINEASSEGRVVCYYTNWSVYRPGTAKFNPQNINPYLCTHLVYAFGGFTKDNQMKPFD 79
            :||.||:.:       .:.||:||||.||||..|:.|.|::|:|||||.|||......|::   .
Zfish    13 VLCHLAFSM-------EMGCYFTNWSQYRPGIGKYTPANVDPFLCTHLFYAFAMINHANEL---I 67

  Fly    80 KYQDIEQGGYAKFTGLKTYNKQLKTMIAIGGWNEASSRFSPLVASNERRQQFIKNILKFLRQNHF 144
            .|:..::..|..|..||..|..|:|::|:||||..|::||.:|:|...||.||::.:||||...|
Zfish    68 TYEWNDETLYKAFNELKNTNPHLRTLLAVGGWNFGSTQFSIMVSSAANRQTFIQSSIKFLRTYGF 132

  Fly   145 DGIDLDWEYPAHREGGKSRDRDNYAQFVQELRAEFEREAEKTGRTRLLLTMAVPAGIEYIDKGYD 209
            ||:|||||||..| |....|:..:....:||...:|.|.:.|||.||:|:.||.||...||.||:
Zfish   133 DGMDLDWEYPGSR-GSPPEDKQRFTLLCKELLEAYEAEGKATGRRRLMLSAAVSAGKGTIDDGYE 196

  Fly   210 VPKLNKYLDWFNVLTYDFHSSHEPSVNHHAPLYSLEEDSEYNYDAEL---NIDYSIKYYLKAGAD 271
            :.::.||||:.|::|||||.:.|....|::|||...:|     :.:|   |.||:::|:...|..
Zfish   197 IAEIAKYLDFINIMTYDFHGTWERFTGHNSPLYQGSKD-----EGDLVYFNTDYAMRYWRDNGTP 256

  Fly   272 RDKLVLGIPTYGRSYTLINEESTELGAPAEGPGEQGDATREKGYLAYYEICQTLKDDPEWTVVQP 336
            .:||.:|..||||::.|.:.: |.:||||.||...|..|||.|:.:|||||..|    |.|.||.
Zfish   257 VEKLRMGFATYGRTFRLTSSD-TSVGAPASGPASAGTYTREAGFWSYYEICGFL----EGTTVQW 316

  Fly   337 NANVMGPYAYRRNQWVGYDDEAIVRKKAEYVVAQGLGGIMFWAIDNDDFRGT-CNGKPYPLIEAA 400
            ..:...|||.:.::|||:|.:.....|..|:..:..||...||:|.|||.|. |....:||:...
Zfish   317 IDDQKVPYATKNSEWVGFDTKESYETKVRYLKDKKFGGAFVWALDLDDFAGQFCGQGNHPLMGHL 381

  Fly   401 KEAMVEALGLGINEVAKPSGPQKPSRSRSRDNASNRNRLNGKTEAPLSSRRPSATRRPAVSSTQA 465
            :..:         ::..|..|                              |..|.:|..|:|:
Zfish   382 RNLL---------DIELPPLP------------------------------PPTTAKPGQSTTR- 406

  Fly   466 PPPSTTFKLTEAEGSSLYIGGRASTTPPPPTTPDPGSDFKC--EEEGFFQHPRDCKKYYWCLDSG 528
              |:||                 :||    ||..||..| |  :.:|.:.|| |..|||.|
Zfish   407 --PTTT-----------------TTT----TTHAPGPGF-CNGKPDGLYAHP-DPNKYYSC---- 442

  Fly   529 PSGLGIVAHMFTCPSGLYFNPAADSCDFARN 559
               .|...::..|.:|..|:.:...|.:.::
Zfish   443 ---AGGQTYVDNCGAGTEFDESCKCCGWPKH 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht6	NP_001245598.1	Glyco_18	31..383	CDD:214753	146/354 (41%)
		GH18_chitolectin_chitotriosidase	32..404	CDD:119351	153/375 (41%)
		CBM_14	506..562	CDD:279884	14/56 (25%)
		Oxidored_q2	<2691..2750	CDD:294335
		CBM_14	4554..4609	CDD:279884
chia.2	NP_998414.1	GH18_chitolectin_chitotriosidase	23..385	CDD:119351	153/375 (41%)
		Glyco_18	24..363	CDD:214753	146/352 (41%)
		CBM_14	423..468	CDD:279884	14/52 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1289629at2759
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020