DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht6 and Muc96D

DIOPT Version :9

Sequence 1:	NP_001245598.1	Gene:	Cht6 / 31935	FlyBaseID:	FBgn0263132	Length:	4611	Species:	Drosophila melanogaster
Sequence 2:	NP_733106.2	Gene:	Muc96D / 318737	FlyBaseID:	FBgn0051439	Length:	881	Species:	Drosophila melanogaster

Alignment Length:	1440	Identity:	290/1440 - (20%)
Similarity:	402/1440 - (27%)	Gaps:	725/1440 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly   515 PRDCKKYYWCLDSGPSGLGIVAHMFTCP------------------SGLYFNPAADS-------- 553
            |..|.::|.|.:.       ||..:|||                  .|:...|.|..
  Fly    41 PGSCSRFYECQNG-------VAKEYTCPKFYDFKIRSCVTYNTGCVEGVVVKPVAQQSVRDTAQP 98

  Fly   554 CDFARNV--PCKT-----KKSTTAAPV------TSTTPATTTVRSNRVTAAPTSRPVYPRTTTTT 605
            |:.|...  ||.|     .|:||..|.      |:||||:||..:...|         |.|||||
  Fly    99 CNGATTTPPPCATTTPPCTKTTTQTPCSGIITSTTTTPASTTTTTTTCT---------PTTTTTT 154

  Fly   606 STTTTTTTTPSTVDEDLEYEEDTDELSPSKSTDAEEDPQVIKELIDLIRKVGGVEQLEKHLLRNK 670
            |||||||||.:|.         |...:|:.:|
  Fly   155 STTTTTTTTTTTT---------TTTCTPTTTT--------------------------------- 177

  Fly   671 DGSITLKENSATGAATTPSTISKSLYDRVLSRPGTLNSFSRNRFKISEASETSTEPTTSSSSSRG 735
                |....:.|...||.:|.:.:........|.|                |:|..||:::::..
  Fly   178 ----TTTTTTTTTTTTTTTTTTTTTTTTTTCTPTT----------------TTTTTTTTTTTTTT 222

  Fly   736 SSTLTSNTNSKYSSVLRGNSRQGPQNEGIEKLAEFDGFLKERKQYVTINRHRSASQGDEEEHADQ 800
            ::|.|:.|.:
  Fly   223 TTTTTTTTTT------------------------------------------------------- 232

  Fly   801 QEEEENLAEVETTTRRPLSSITPSYTSLRRSRPTTVAPPAEESHEEAEQQTQTQVKSYATLSRTR 865
                      .|||..|.::.|.:.|:...:..||.....          |.|...:..|.:.|.
  Fly   233 ----------TTTTCTPTTTTTTTTTTTTTTTTTTTTTTT----------TCTPTTTTTTTTTTT 277

  Fly   866 GRTTSSPEVTEAAPSSTTNRYKYFERTRPTKSATAEDSEDPTEDEEEEYEDEQKDIVTVQSKQST 930
            ..||::...|...|::||        |..|.:.|.                     .|..:..:|
  Fly   278 TTTTTTTTTTTCTPTTTT--------TTTTTTTTT---------------------TTTTTTTTT 313

  Fly   931 NTRKYASIGRRTTTTTTATPETTTTTTTTTAGTETAKASTTTNNNNNNNSHYNSSNNNNNVKLNN 995
            .|         ||||||.||.|||||||||..|.|...:|||.......:
  Fly   314 TT---------TTTTTTCTPTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT--------------- 354

  Fly   996 QLPTEENITTTPSTTAQSETTTTTNETTEPNESTSTTTTSITNNLHTTTTTPTPIVASTVPTTTA 1060
            ..||....|||.:||..:.|||||..|..|..:|:||||:.|....|||.|||....:|..|||.
  Fly   355 CTPTTTTTTTTTTTTTTTTTTTTTTTTCTPTTTTTTTTTTTTTTTTTTTCTPTTTTTTTSTTTTT 419

  Fly  1061 NGISSDSLLATELSEASPTHLSPSPDSETSTPTTTSTTTTEQPELDTTTTTPKTTTTTTTGNNEL 1125
            ...::.:...|..:..:||..:.:..:.|:|.|||:||||..|...|||||..|||||||
  Fly   420 TTTTTTTTTTTTTTTCTPTTTTTTTTTTTTTTTTTTTTTTCTPTTTTTTTTTTTTTTTTT----- 479

  Fly  1126 NDVNNVDEDSEVTKTKTQYKYATTNRRRITTTTTTATKNSNNNNNAEAANDASPTTNGLSSLNSI 1190
                    .:..|.|.|.....||.....||||||.|              .:|||
  Fly   480 --------TTTTTTTTTTCTPTTTTTTTTTTTTTTTT--------------TTPTT--------- 513

  Fly  1191 RTNPGRRQPQPEQTQTTTSEPNLSSPRPFGYPRRRTRPTVSTTTTTISQTDNDNNTDNNDNETDA 1255
                           |||..|              |..|.:|||||.:.|.....|
  Fly   514 ---------------TTTCTP--------------TTTTTTTTTTTTTTTTTTTTT--------- 540

  Fly  1256 VAQVVKKTRLSPGDRPKVSASLPTATAINTRTNTSSLHHQESQVEVAGNGGNDSLRHDVVSSSLS 1320
                               ...||.|...|.|.|:
  Fly   541 -------------------TCTPTTTTTTTTTTTT------------------------------ 556

  Fly  1321 QSQSNKIDTDDLSTTQQHTKYTWRAVRRPASQRTVVPNSLAGDDKDSRRFAGKQLNTESIVDDEL 1385
                        :||
  Fly   557 ------------TTT-------------------------------------------------- 559

  Fly  1386 QTTTKFRSRRLNSAEDESEVALEVATATPTHGSRSYQSIQRSASKASLDDSQIHYKAIIRDSEGG 1450
             |||                    ||.|||
  Fly   560 -TTT--------------------ATTTPT----------------------------------- 568

  Fly  1451 AHLTAGRSSSFVRNFGDAAKPTPPHQPISRGGQIVESTTEDENVAAEIIDDEKRGETKAPAGSEN 1515
                                                 ||
  Fly   569 -------------------------------------TT-------------------------- 570

  Fly  1516 TDDSNTATEQESPEIVTEAAQPQLEITTLPSETSDVSSSTEQSVSSTTEESSSSTADLDIVAEEA 1580
                                      |..|:.|:..:::|..:.::||
  Fly   571 --------------------------TCTPTTTTTTTTTTTTTTTTTT----------------- 592

  Fly  1581 SLGAETDKKSTSENDNGESSTEISSSEAPISSTTGQSEDVSSTTETNSEAIEKEIASDSNDGSSD 1645
                                |..:::..|.::||..:...::||.|
  Fly   593 --------------------TTTTTTCTPTTTTTTTTTTTTTTTTT------------------- 618

  Fly  1646 DPASSTEFIEITNTTSSPVSLQEDSSTTTEKLTRRAFNRFSSTTPAVVPEDETTSTVNQRRRVIV 1710
                 |.....|.||.:|.:....::|||...|...    ::||....|...||:|
  Fly   619 -----TTTTTTTTTTCTPTTTTTTTTTTTTTTTTTT----TTTTTTCTPTTTTTTT--------- 665

  Fly  1711 RNRISTTEAESEAQTTTEEPKRRSFYRTSTTAEPSSSTEADSDAQISTETTTRRSFFRTRTTEAA 1775
                 ||       |||          |:||..|:::|...:....:|.|||..:...|.||...
  Fly   666 -----TT-------TTT----------TTTTCTPTTTTTTTTTTTTTTTTTTCTTTTTTTTTTTT 708

  Fly  1776 SSTTEEPSSPTEPEIEVETTTEGPTRRSFFRRSTTVAPSSTTEEISSSSVDDDAEANIITTRRSL 1840
            ::||             .|||..||      .:||..|::||.
  Fly   709 TTTT-------------TTTTCAPT------TTTTCTPTTTTT---------------------- 732

  Fly  1841 FTTPAPSSTEATTTATAEDSEVSSSTRRSFFRTSTTTEGTTSTTEEAKDI-----EHESETTAAL 1900
             ||.||:::..|||:|       ::|..|...::||...|..||....|:     ..||:..||.
  Fly   733 -TTCAPTTSSTTTTST-------TTTCTSKTISTTTCPETAPTTTACSDVTTTVCPTESKAVAAT 789

  Fly  1901 PKRRVIVRGN 1910
            ..:|..||.|
  Fly   790 QSKRNPVRRN 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht6	NP_001245598.1	Glyco_18	31..383	CDD:214753
		GH18_chitolectin_chitotriosidase	32..404	CDD:119351
		CBM_14	506..562	CDD:279884	14/74 (19%)
		Oxidored_q2	<2691..2750	CDD:294335
		CBM_14	4554..4609	CDD:279884
Muc96D	NP_733106.2	ChtBD2	29..72	CDD:214696	9/37 (24%)
Muc96D	NP_733106.2	CBM_14	827..875	CDD:279884
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900