DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht6 and Chil1

DIOPT Version :9

Sequence 1:	NP_001245598.1	Gene:	Cht6 / 31935	FlyBaseID:	FBgn0263132	Length:	4611	Species:	Drosophila melanogaster
Sequence 2:	NP_031721.2	Gene:	Chil1 / 12654	MGIID:	1340899	Length:	389	Species:	Mus musculus

Alignment Length:	381	Identity:	154/381 - (40%)
Similarity:	237/381 - (62%)	Gaps:	18/381 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 EASSEGRVVCYYTNWSVYRPGTAKFNPQNINPYLCTHLVYAFGGFTKDNQMKPFDKYQDIEQGGY 89
            ::.|..::|||:|:||.||.|...|.|..|.|:||||::|:|...:.||.:..:: :.|  :..|
Mouse    25 QSCSAYKLVCYFTSWSQYREGVGSFLPDAIQPFLCTHIIYSFANISSDNMLSTWE-WND--ESNY 86

  Fly    90 AKFTGLKTYNKQLKTMIAIGGWNEASSRFSPLVASNERRQQFIKNILKFLRQNHFDGIDLDWEYP 154
            .|...|||.|..|||::::|||.....|||.:.::.|||..|::::..|||...|||:||.|.||
Mouse    87 DKLNKLKTRNTNLKTLLSVGGWKFGEKRFSEIASNTERRTAFVRSVAPFLRSYGFDGLDLAWLYP 151

  Fly   155 AHREGGKSRDRDNYAQFVQELRAEFEREAEKTGRTRLLLTMAVPAGIEYIDKGYDVPKLNKYLDW 219
                  :.||:..::..::||.|||.:|.: .||.:|||:.|:.||...||.|||:.::.::||:
Mouse   152 ------RLRDKQYFSTLIKELNAEFTKEVQ-PGREKLLLSAALSAGKVAIDTGYDIAQIAQHLDF 209

  Fly   220 FNVLTYDFHSSHEPSVNHHAPLYSLEEDSEYNYDAELNIDYSIKYYLKAGADRDKLVLGIPTYGR 284
            .|::|||||........||:||:..::|:  .:|...|::|:::|.::.||...||::||||:|:
Mouse   210 INLMTYDFHGVWRQITGHHSPLFQGQKDT--RFDRYSNVNYAVQYMIRLGAQASKLLMGIPTFGK 272

  Fly   285 SYTLINEESTELGAPAEGPGEQGDATREKGYLAYYEICQTLKDDPEWTVVQPNANVMGPYAYRRN 349
            |:||.:.|: :||||..|.|..|..|:|.|.|||||||..||.    ..|...:|...|:|.:.|
Mouse   273 SFTLASSEN-QLGAPISGEGLPGRFTKEAGTLAYYEICDFLKG----AEVHRLSNEKVPFATKGN 332

  Fly   350 QWVGYDDEAIVRKKAEYVVAQGLGGIMFWAIDNDDFRGTCNGKP-YPLIEAAKEAM 404
            |||||:|:..|:.|..::..:.|.|.|.||:|.|||:|||..|. :||..|.|:|:
Mouse   333 QWVGYEDKESVKNKVGFLKEKKLAGAMVWALDLDDFQGTCQPKEFFPLTNAIKDAL 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht6	NP_001245598.1	Glyco_18	31..383	CDD:214753	141/351 (40%)
		GH18_chitolectin_chitotriosidase	32..404	CDD:119351	152/372 (41%)
		CBM_14	506..562	CDD:279884
		Oxidored_q2	<2691..2750	CDD:294335
		CBM_14	4554..4609	CDD:279884
Chil1	NP_031721.2	GH18_chitolectin_chitotriosidase	32..388	CDD:119351	152/372 (41%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	79..80		0/1 (0%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	106..109		2/2 (100%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	213..216		1/2 (50%)
		Important for AKT1 activation and IL8 production	333..347		7/13 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910