DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht6 and Chia

DIOPT Version :9

Sequence 1:	NP_001245598.1	Gene:	Cht6 / 31935	FlyBaseID:	FBgn0263132	Length:	4611	Species:	Drosophila melanogaster
Sequence 2:	NP_997469.1	Gene:	Chia / 113901	RGDID:	1303058	Length:	473	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	197/551 - (35%)
Similarity:	290/551 - (52%)	Gaps:	89/551 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LFLLCALAYCIN-EASSEGRVVCYYTNWSVYRPGTAKFNPQNINPYLCTHLVYAFGGFTKDNQMK 76
            |.|:..|...:| :..|...:|||:|||:.||||...|.|.:|||.|||||:|||.|. ::||:.
  Rat     4 LILVTGLVLLLNVQLGSAYNLVCYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGM-QNNQIT 67

  Fly    77 PFDKYQDIEQGGYAKFTGLKTYNKQLKTMIAIGGWNEASSRFSPLVASNERRQQFIKNILKFLRQ 141
            ..: :.|:..  |..|..||..|.:|||::||||||..::.|:.:|::::.||.||.:::|||||
  Rat    68 TIE-WNDVTL--YKAFNDLKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSVIKFLRQ 129

  Fly   142 NHFDGIDLDWEYPAHREGGKSRDRDNYAQFVQELRAEFEREAEKTGRTRLLLTMAVPAGIEYIDK 206
            ..|||:|||||||..| |...:|:..:...|:|||..||:||.::.|.||::|.||.|||..|..
  Rat   130 YGFDGLDLDWEYPGSR-GSPPQDKHLFTVLVKELREAFEQEAIESNRPRLMVTAAVAAGISNIQA 193

  Fly   207 GYDVPKLNKYLDWFNVLTYDFHSSHEPSVNHHAPLYSLEEDSEYNYDAELNIDYSIKYYLKAGAD 271
            ||::|:|::|||:.:|:|||.|.|.:.....::|||.|..::..|  |.||:||.:.|:...||.
  Rat   194 GYEIPELSQYLDFIHVMTYDLHGSWDGYTGENSPLYKLPTETGSN--AYLNVDYVMNYWKDNGAP 256

  Fly   272 RDKLVLGIPTYGRSYTLINEESTELGAPAEGPGEQGDATREKGYLAYYEICQTLKD--DPEWTVV 334
            .:||::|.|.||.:|.|.|...|.:|||..|.|..|..||:.|:.||||||..|::  ..:|...
  Rat   257 AEKLIVGFPEYGHTYILSNPSDTGIGAPTSGNGPAGPYTRQAGFWAYYEICTFLRNGATQDWDAP 321

  Fly   335 QPNANVMGPYAYRRNQWVGYDDEAIVRKKAEYVVAQGLGGIMFWAIDNDDFRGT-CNGKPYPLIE 398
            |.     .||||:.|:|||||:......||:::.....||.|.||||.|||.|: |:...:||..
  Rat   322 QE-----VPYAYKGNEWVGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCDQGKFPLTS 381

  Fly   399 AAKEAM-VEALGLGINEVAKPSGPQKPSRSRSRDNASNRNRLNGKTEAPLSSRRPSATRRPAVSS 462
            ...:|: :...|.        :.|..||                         .|..|
  Rat   382 TLNKALDIPTAGC--------TAPDLPS-------------------------EPVTT------- 406

  Fly   463 TQAPPPSTTFKLTEAEGSSLYIGGRASTTPPPPTTPDPGSDFKC--EEEGFFQHPRDCKKYYWCL 525
               ||.|.:     ..|||   ||.:.           ||.| |  :.:|.:....|...::.|:
  Rat   407 ---PPGSGS-----GGGSS---GGGSE-----------GSGF-CAGKADGLYPVADDRNAFWHCI 448

  Fly   526 DSGPSGLGIVAHMFTCPSGLYFNPAADSCDF 556
                :|:....|   |.:||.|:.:.:.|::
  Rat   449 ----NGITYQQH---CQAGLVFDTSCNCCNW 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht6	NP_001245598.1	Glyco_18	31..383	CDD:214753	156/353 (44%)
		GH18_chitolectin_chitotriosidase	32..404	CDD:119351	163/374 (44%)
		CBM_14	506..562	CDD:279884	11/53 (21%)
		Oxidored_q2	<2691..2750	CDD:294335
		CBM_14	4554..4609	CDD:279884
Chia	NP_997469.1	GH18_chitolectin_chitotriosidase	24..387	CDD:119351	163/374 (44%)
		Glyco_18	24..365	CDD:214753	156/352 (44%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	70..71		0/1 (0%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	97..100		2/2 (100%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	210..213		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..421		13/68 (19%)
		ChtBD2	426..473	CDD:214696	12/55 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920