back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht6 and CHI3L2

DIOPT Version :9

Sequence 1:	NP_001245598.1	Gene:	Cht6 / 31935	FlyBaseID:	FBgn0263132	Length:	4611	Species:	Drosophila melanogaster
Sequence 2:	NP_003991.2	Gene:	CHI3L2 / 1117	HGNCID:	1933	Length:	390	Species:	Homo sapiens

Alignment Length:	406	Identity:	163/406 - (40%)
Similarity:	239/406 - (58%)	Gaps:	41/406 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WQTLFLLCALAYCINEASSEGRVVCYYTNWSVYRPGTAKFNPQNINPYLCTHLVYAFGGFTKDNQ 74
            |..:.:|..|     :..|..::|||:||||..|....||.|:||:|:||:||:|:|... ::|:
Human    12 WAGVVVLLLL-----QGGSAYKLVCYFTNWSQDRQEPGKFTPENIDPFLCSHLIYSFASI-ENNK 70

  Fly    75 MKPFDK-----YQDIEQGGYAKFTGLKTYNKQLKTMIAIGGWNEASSRFSPLVASNERRQQFIKN 134
            :...||     ||.|        ..|||.|.:||.:::|||:...|..|.|:|.|:..|.:||.:
Human    71 VIIKDKSEVMLYQTI--------NSLKTKNPKLKILLSIGGYLFGSKGFHPMVDSSTSRLEFINS 127

  Fly   135 ILKFLRQNHFDGIDLDWEYPAHREGGKSRDRDNYAQFVQELRAEFEREAEKTGRTRLLLTMAVPA 199
            |:.|||.::|||:|:.|.||..:|      ..::...:.||...|:::..|:.:.|||||..|.|
Human   128 IILFLRNHNFDGLDVSWIYPDQKE------NTHFTVLIHELAEAFQKDFTKSTKERLLLTAGVSA 186

  Fly   200 GIEYIDKGYDVPKLNKYLDWFNVLTYDFHSSHEPSV--NHHAPLYSLEED---SEYNYDAELNID 259
            |.:.||..|.|.||.|.||:.|:|::|||.|.|..:  .|::||....:|   |.|     .|::
Human   187 GRQMIDNSYQVEKLAKDLDFINLLSFDFHGSWEKPLITGHNSPLSKGWQDRGPSSY-----YNVE 246

  Fly   260 YSIKYYLKAGADRDKLVLGIPTYGRSYTLINEESTELGAPAEGPGEQGDATREKGYLAYYEICQT 324
            |::.|::..|...:|:|:||||||.|:||.:.|:| :||||.|||..|..|...|:||||||||.
Human   247 YAVGYWIHKGMPSEKVVMGIPTYGHSFTLASAETT-VGAPASGPGAAGPITESSGFLAYYEICQF 310

  Fly   325 LKDDPEWTVVQPNANVMGPYAYRRNQWVGYDDEAIVRKKAEYVVAQGLGGIMFWAIDNDDFRG-T 388
            || ..:.|.:|   :...|||.:.||||||||...:..|.:::....|||.|.|:||.|||.| :
Human   311 LK-GAKITRLQ---DQQVPYAVKGNQWVGYDDVKSMETKVQFLKNLNLGGAMIWSIDMDDFTGKS 371

  Fly   389 CNGKPYPLIEAAKEAM 404
            ||..||||::|.|.::
Human   372 CNQGPYPLVQAVKRSL 387

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.